# Protein-Protein Interaction Dataset
**Source**: http://www.csb.iitkgp.ac.in/databases/TFNRDv1.0/TFNRDv1.0_PP.html
**Parent**: http://www.csb.iitkgp.ac.in/databases/TFNRDv1.0/tfnrd.html
## Protein-Protein Interaction Interfaces
**Table S1.B:** Protein-protein interface present in transcription binding dataset.
| **PDB ID** | **PDB Chain Id** | **Protein** | **Source Organism** | **Protein length** | **Experimental Methods** | **Resolution (Å)** | **Oligomeric State** | **Chain** | **BSA** | | | |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| | | | | | | | | **Protein 1** | **Protein 2** | **Protein-Protein** | **Protein 1** | **Protein 2** |
| **I. DNA-binding Transcription Factors** | | | | | | | | | | | | | | |
| | | | | | | | | | | | |
| 1A02 | NFJ:AB | AP-1 FRAGMENT FOS + NUCLEAR FACTOR OF ACTIVATED T CELLS | *H. sapiens* | 301+56 | X | 2.7 | Homodimer + Monomer | N | F | 799 | 411 | 388 |
| 1A02 | NFJ:AB | AP-1 FRAGMENT FOS + NUCLEAR FACTOR OF ACTIVATED T CELLS | *H. sapiens* | 301+56 | X | 2.7 | Homodimer + Monomer | N | J | 651 | 316 | 335 |
| 1A0A | AB:CD | PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4 | *S. cerevisiae* | 63 | X | 2.8 | Homodimer | A | B | 1860 | 933 | 927 |
| 1AM9 | ABCD:EFGH | STEROL REGULATORY ELEMENT BINDING PROTEIN 1A | *H. sapiens* | 82 | X | 2.3 | Homodimer | A | B | 2839 | 1422 | 1417 |
| 1AN2 | A:B | TRANSCRIPTION FACTOR MAX (TF MAX) | *H. sapiens* | 86 | X | 2.9 | Homodimer | A | B | 919 | 449 | 470 |
| 1AN4 | AB:CD | UPSTREAM STIMULATORY FACTOR | *H. sapiens* | 65 | X | 2.9 | Homodimer | A | B | 1535 | 771 | 764 |
| 1APL | CD:AB | MAT-ALPHA2 HOMEODOMAIN | *S. cerevisiae* | 83 | X | 2.7 | Monomer | C | D | 0 | 0 | 0 |
| 1AWC | AB:DE | GA BINDING PROTEIN ALPHA + GA BINDING PROTEIN BETA 1 | *M. musculus* | 110+153 | X | 2.1 | Heterodimer | A | B | 1654 | 800 | 853 |
| 1B01 | AB:EF | TRANSCRIPTIONAL REPRESSOR COPG | *S. agalactiae* | 45 | X | 2.5 | Homodimer | A | B | 3295 | 1661 | 1635 |
| 1B3T | AB:CD | NUCLEAR PROTEIN EBNA1 | *E. virus* | 147 | X | 2.2 | Homodimer | A | B | 4397 | 2208 | 2189 |
| 1B72 | AB:DE | HOMEOBOX PROTEIN HOX-B1 + PBX1 | *H. sapiens* | 87+97 | X | 2.3 | Heterodimer | A | B | 763 | 400 | 363 |
| 1BF5 | A:BC | SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA | *H. sapiens* | 575 | X | 2.9 | Homodimer | A | B | 2598 | 1299 | 1299 |
| 1CF7 | AB:CD | TRANSCRIPTION FACTOR DP-2 + TRANSCRIPTION FACTOR E2F-4 | *H. sapiens* | 76+95 | X | 2.6 | Heterodimer | A | B | 1271 | 636 | 635 |
| 1CGP | AB:CDEF | CATABOLITE GENE ACTIVATOR PROTEIN (CAP) | *E. coli* | 205 | X | 3.0 | Homodimer | A | B | 3020 | 1515 | 1504 |
| 1CMA | AB:CD | MET REPRESSOR | *E. coli* | 104 | X | 2.8 | Homodimer | A | B | 3193 | 1599 | 1594 |
| 1D66 | AB:DE | GAL4 | *S. cerevisiae* | 66 | X | 2.7 | Homo 2-mer | A | B | 1295 | 637 | 657 |
| 1DDN | ABCD:EF | DIPHTHERIA TOX REPRESSOR | *C. diphtheriae* | 226 | X | 3.0 | Homo 4-mer | A | B | 1654 | 823 | 832 |
| 1DH3 | AC:BD | TRANSCRIPTION FACTOR CREB | *M. musculus* | 55 | X | 3.0 | Homodimer | A | C | 1901 | 921 | 980 |
| 1EFA | ABC:DE | LAC REPRESSOR | *E. coli* | 333 | X | 2.6 | Homodimer | A | B | 4317 | 2164 | 2153 |
| 1EGW | ABCD:EFGH | MADS BOX TRANSCRIPTION ENHANCER FACTOR 2, POLYPEPTIDE A | *H. sapiens* | 77 | X | 1.5 | Homodimer | A | B | 3891 | 1953 | 1938 |
| 1EXJ | A:M | MULTIDRUG-EFFLUX TRANSPORTER REGULATOR | *B. subtilis* | 278 | X | 3.0 | Homodimer | A | B | 5963 | 2982 | 2982 |
| 1GD2 | EFGHIJ:ABCD | TRANSCRIPTION FACTOR PAP1 | *S. pombe* | 70 | X | 2.0 | Homodimer | E | F | 2302 | 1159 | 1144 |
| 1GLU | AB:CD | GLUCOCORTICOID RECEPTOR | *R. norvegicus* | 81 | X | 2.9 | Homodimer | A | B | 1240 | 611 | 629 |
| 1GT0 | CD:AB | OCTAMER-BINDING TRANSCRIPTION FACTOR 1 + TRANSCRIPTION FACTOR SOX-2 | *M. musculus* | 159+80 | X | 2.6 | Hetero 2-mer | C | D | 256 | 129 | 127 |
| 1GXP | ABEF:CDGH | PHOSPHATE REGULON TRANSCRIPTIONAL REGULATORY PROTEIN | *E. coli* | 106 | X | 2.5 | Homodimer | A | B | 792 | 379 | 414 |
| 1H88 | ABC:DE | CCAAT/ENHANCER BINDING PROTEIN BETA + MYB PROTO-ONCOGENE PROTEIN | *M. musculus* | 159+78 | X | 2.8 | Homodimer + Monomer | A | B | 2015 | 1006 | 1009 |
| 1HJB | ABCDEF:GHIJ | CCAAT/ENHANCER BINDING PROTEIN BETA + RUNT-RELATED TRANSCRIPTION FACTOR 1 | *M. musculus* | 123+87 | X | 3.0 | Homodimer + Monomer | A | B | 1941 | 987 | 955 |
| 1HWT | CDGH:ABEF | HEME ACTIVATOR PROTEIN | *S. cerevisiae* | 81 | X | 2.5 | Homodimer | C | D | 2279 | 1142 | 1137 |
| 1IC8 | AB:EF | HEPATOCYTE NUCLEAR FACTOR 1-ALPHA | *H. sapiens* | 194 | X | 2.6 | Homodimer | A | B | 444 | 211 | 233 |
| 1IHF | AB:CDE | INTEGRATION HOST FACTOR (ALPHA) + INTEGRATION HOST FACTOR (BETA) (IHF) | *E. coli* | 94+99 | X | 2.5 | Hetero 2-mer | A | B | 4865 | 2435 | 2430 |
| 1IO4 | ABCD:EF | CAAT/ENHANCER BINDING PROTEIN BETA + CORE-BINDING FACTOR, BETA SUBUNIT + RUNT-RELATED TRANSCRIPTION FACTOR 1 | *M. musculus* | 123+141+78 | X | 3.0 | Hetero 4-mer | A | B | 1925 | 969 | 956 |
| 1IO4 | ABCD:EF | CAAT/ENHANCER BINDING PROTEIN BETA + CORE-BINDING FACTOR, BETA SUBUNIT + RUNT-RELATED TRANSCRIPTION FACTOR 1 | *M. musculus* | 123+141+78 | X | 3.0 | Hetero 4-mer | C | D | 2154 | 1085 | 1068 |
| 1JE8 | ABEF:CDGH | Nitrate/Nitrite Response Regulator Protein NARL | *E. coli* | 82 | X | 2.1 | Homodimer | A | B | 809 | 407 | 402 |
| 1JFI | ABC:DE | TATA-BOX-BINDING PROTEIN (TBP) + Transcription Regulator NC2 alpha chain + Transcription Regulator NC2 beta chain | *H. sapiens* | 179+185+98 | X | 2.6 | Hetero 3-mer | A | B | 3988 | 1978 | 2010 |
| 1JFI | ABC:DE | TATA-BOX-BINDING PROTEIN (TBP) + Transcription Regulator NC2 alpha chain + Transcription Regulator NC2 beta chain | *H. sapiens* | 179+185+98 | X | 2.6 | Hetero 3-mer | A | C | 429 | 186 | 243 |
| 1JFI | ABC:DE | TATA-BOX-BINDING PROTEIN (TBP) + Transcription Regulator NC2 alpha chain + Transcription Regulator NC2 beta chain | *H. sapiens* | 179+185+98 | X | 2.6 | Hetero 3-mer | B | C | 1437 | 749 | 687 |
| 1JT0 | ABCD:EF | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION | *S. aureus* | 194 | X | 2.9 | Homo 4-mer | A | C | 3045 | 1522 | 1524 |
| 1JT0 | ABCD:EF | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION | *S. aureus* | 194 | X | 2.9 | Homo 4-mer | B | D | 2923 | 1435 | 1488 |
| 1KU7 | AD:BC | sigma factor sigA | *T. aquaticus* | 73 | X | 2.4 | Homodimer | A | D | 1939 | 1003 | 936 |
| 1L3L | ABCD:EFGH | Transcriptional activator protein traR | *A. tumefaciens* | 234 | X | 1.6 | Homodimer | B | D | 3251 | 1647 | 1604 |
| 1LMB | 12:34 | LAMBDA REPRESSOR | *E. phage lambda* | 92 | X | 1.8 | Hetero 2-mer | 3 | 4 | 1463 | 730 | 732 |
| 1LQ1 | CD:EF | Stage 0 sporulation protein A | *B. subtilis* | 120 | X | 2.3 | Homo 2-mer | C | D | 882 | 436 | 445 |
| 1MDY | ABCD:EFGH | MYOD BHLH DOMAIN + MYOD BHLH DOMAIN | *M. musculus* | 62+68 | X | 2.8 | Homo 2-mer | A | B | 1688 | 848 | 839 |
| 1MHD | AB:CD | SMAD3 | *H. sapiens* | 132 | X | 2.8 | Homo 2-mer | A | B | 42 | 21 | 21 |
| 1MNM | ABCD:EF | MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR + MCM1 TRANSCRIPTIONAL REGULATOR | *S. cerevisiae* | 100+87 | X | 2.2 | Hetero 4-mer | A | B | 3821 | 1900 | 1921 |
| 1N6J | ABG:CD | Calcineurin-binding protein Cabin 1 + Myocyte-specific enhancer factor 2B | *H. sapiens* | 35+93 | X | 2.2 | Hetero 3-mer | A | B | 6236 | 3112 | 3124 |
| 1N6J | ABG:CD | Calcineurin-binding protein Cabin 1 + Myocyte-specific enhancer factor 2B | *H. sapiens* | 35+93 | X | 2.2 | Hetero 3-mer | A | G | 972 | 482 | 490 |
| 1N6J | ABG:CD | Calcineurin-binding protein Cabin 1 + Myocyte-specific enhancer factor 2B | *H. sapiens* | 35+93 | X | 2.2 | Hetero 3-mer | B | G | 1091 | 548 | 543 |
| 1NGM | ABEFIJMN: CDGHKLOP | Transcription factor IIIB BRF1 subunit + Transcription initiation factor TFIID | *S. cerevisiae* | 180+72 | X | 2.9 | Hetero 2-mer | A | B | 3800 | 1865 | 1935 |
| 1NKP | ABDE:FGHJ | Max protein + Myc proto-oncogene protein | *H. sapiens* | 83+88 | X | 1.8 | Hetero 2-mer | A | B | 3368 | 1687 | 1681 |
| 1NLW | ABDE:FGHJ | MAD + MAX PROTEIN | *H. sapiens* | 76+80 | X | 2.0 | Hetero 2-mer | A | B | 2983 | 1500 | 1483 |
| 1NVP | ABCD:EF | TATA box binding protein + Transcription initiation factor IIA alpha chain + Transcription initiation factor IIA beta chain + Transcription initiation factor IIA gamma chain | *H. sapiens* | 108+181+57+76 | X | 2.1 | Hetero 4-mer | A | C | 501 | 230 | 271 |
| 1NVP | ABCD:EF | TATA box binding protein + Transcription initiation factor IIA alpha chain + Transcription initiation factor IIA beta chain + Transcription initiation factor IIA gamma chain | *H. sapiens* | 108+181+57+76 | X | 2.1 | Hetero 4-mer | A | D | 1042 | 479 | 563 |
| 1NVP | ABCD:EF | TATA box binding protein + Transcription initiation factor IIA alpha chain + Transcription initiation factor IIA beta chain + Transcription initiation factor IIA gamma chain | *H. sapiens* | 108+181+57+76 | X | 2.1 | Hetero 4-mer | B | C | 264 | 131 | 132 |
| 1NVP | ABCD:EF | TATA box binding protein + Transcription initiation factor IIA alpha chain + Transcription initiation factor IIA beta chain + Transcription initiation factor IIA gamma chain | *H. sapiens* | 108+181+57+76 | X | 2.1 | Hetero 4-mer | B | D | 1817 | 909 | 908 |
| 1NVP | ABCD:EF | TATA box binding protein + Transcription initiation factor IIA alpha chain + Transcription initiation factor IIA beta chain + Transcription initiation factor IIA gamma chain | *H. sapiens* | 108+181+57+76 | X | 2.1 | Hetero 4-mer | C | D | 3223 | 1677 | 1545 |
| 1P51 | ABCD:EFIH | DNA-binding protein HU | *N. sp.* | 94 | X | 2.5 | Homodimer | A | B | 4013 | 1999 | 2014 |
| 1PAR | ABCD:EF | ARC REPRESSOR | *S. phage P22* | 53 | X | 2.6 | Homo 4-mer | A | B | 3603 | 1811 | 1792 |
| 1PNR | A:B | PURINE REPRESSOR | *E. coli* | 340 | X | 2.7 | Homodimer | A | C | 5157 | 2579 | 2579 |
| 1QPI | A:MN | TETRACYCLINE REPRESSOR | *E. coli* | 203 | X | 2.5 | Homodimer | A | B | 4733 | 2367 | 2367 |
| 1QRV | AB:CD | HIGH MOBILITY GROUP PROTEIN D | *D. melanogaster* | 73 | X | 2.2 | Homo 2-mer | A | B | 98 | 55 | 42 |
| 1R71 | ABCD:EIFJGLHK | Transcriptional repressor protein korB | *E. coli* | 178 | X | 2.2 | Homo 2-mer | A | B | 304 | 155 | 148 |
| 1R8D | AB:CD | transcription activator MtaN | *B. subtilis* | 109 | X | 2.7 | Homodimer | A | B | 1980 | 1000 | 980 |
| 1RAM | AB:CD | TRANSCRIPTION FACTOR NF-KB P65 | *M. musculus* | 273 | X | 2.7 | Homo 2-mer | A | B | 1312 | 653 | 659 |
| 1RZR | GCADTLYS:HREB | Glucose-resistance amylase regulator + Phosphocarrier protein HPr | *P. megaterium* | 332+88 | X | 2.8 | Hetero 4-mer | C | G | 4181 | 2084 | 2097 |
| 1RZR | GCADTLYS:HREB | Glucose-resistance amylase regulator + Phosphocarrier protein HPr | *P. megaterium* | 332+88 | X | 2.8 | Hetero 4-mer | C | L | 94 | 44 | 49 |
| 1RZR | GCADTLYS:HREB | Glucose-resistance amylase regulator + Phosphocarrier protein HPr | *P. megaterium* | 332+88 | X | 2.8 | Hetero 4-mer | C | T | 1418 | 684 | 733 |
| 1SAX | AB:CD | Methicillin resistance regulatory protein mecI | *S. aureus* | 123 | X | 2.8 | Homodimer | A | B | 4015 | 1993 | 2022 |
| 1SVC | P:D | NUCLEAR FACTOR KAPPA-B (NF-KB) | *H. sapiens* | 365 | X | 2.6 | Homodimer | P | B | 1358 | 679 | 679 |
| 1T2K | ABCD:EF | Cyclic-AMP-dependent transcription factor ATF-2 + Interferon regulatory factor 3 + Transcription factor AP-1 | *H. sapiens* | 112+61+62 | X | 3.0 | Hetero 4-mer | C | D | 1976 | 986 | 989 |
| 1TQE | PQXRSY:CDEF | Histone deacetylase 9 + Myocyte-specific enhancer factor 2B | *M. musculus* | 26+93 | X | 2.7 | Hetero 3-mer | P | Q | 6055 | 3020 | 3035 |
| 1TQE | PQXRSY:CDEF | Histone deacetylase 9 + Myocyte-specific enhancer factor 2B | *M. musculus* | 26+93 | X | 2.7 | Hetero 3-mer | P | X | 776 | 372 | 404 |
| 1TRR | ABDEGHJK:CFIL | TRP REPRESSOR | *E. coli* | 107 | X | 2.4 | Homo 4-mer | A | B | 4863 | 2435 | 2428 |
| 1TRR | ABDEGHJK:CFIL | TRP REPRESSOR | *E. coli* | 107 | X | 2.4 | Homo 4-mer | A | G | 991 | 497 | 494 |
| 1TUP | ABC:EF | P53 TUMOR SUPPRESSOR | *H. sapiens* | 219 | X | 2.2 | Homo 3-mer | A | B | 1426 | 714 | 712 |
| 1TUP | ABC:EF | P53 TUMOR SUPPRESSOR | *H. sapiens* | 219 | X | 2.2 | Homo 3-mer | B | C | 750 | 378 | 373 |
| 1VOL | AB:CD | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIB (TFIIB) | *A. thaliana* | 200+204 | X | 2.7 | Hetero 2-mer | A | B | 1253 | 590 | 663 |
| 1XBR | AB:CD | T PROTEIN | *X. laevis* | 184 | X | 2.5 | Homodimer | A | B | 415 | 206 | 209 |
| 1YRN | AB:CD | MAT A1 HOMEODOMAIN + MAT ALPHA2 HOMEODOMAIN | *S. cerevisiae* | 61+83 | X | 2.5 | Hetero 2-mer | A | B | 1271 | 615 | 657 |
| 1YSA | CD:AB | GCN4 | *S. cerevisiae* | 58 | X | 2.9 | Homo 2-mer | C | D | 1828 | 903 | 926 |
| 1YTF | ABCD:EF | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIA - TOA1C SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA1N SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA2 SUBUNIT | *S. cerevisiae* | 121+180 +53+79 | X | 2.5 | Hetero 4-mer | A | C | 528 | 252 | 277 |
| 1YTF | ABCD:EF | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIA - TOA1C SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA1N SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA2 SUBUNIT | *S. cerevisiae* | 121+180 +53+79 | X | 2.5 | Hetero 4-mer | A | D | 848 | 395 | 453 |
| 1YTF | ABCD:EF | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIA - TOA1C SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA1N SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA2 SUBUNIT | *S. cerevisiae* | 121+180 +53+79 | X | 2.5 | Hetero 4-mer | B | C | 500 | 251 | 249 |
| 1YTF | ABCD:EF | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIA - TOA1C SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA1N SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA2 SUBUNIT | *S. cerevisiae* | 121+180 +53+79 | X | 2.5 | Hetero 4-mer | B | D | 2071 | 1034 | 1038 |
| 1YTF | ABCD:EF | TATA BINDING PROTEIN (TBP) + TRANSCRIPTION FACTOR IIA - TOA1C SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA1N SUBUNIT + TRANSCRIPTION FACTOR IIA - TOA2 SUBUNIT | *S. cerevisiae* | 121+180 +53+79 | X | 2.5 | Hetero 4-mer | C | D | 3339 | 1732 | 1607 |
| 1Z9C | ABCDEF:GHIJKL | ZIF268 | *B. subtilis* | 87 | X | 2.6 | Homo 2-mer | A | B | 4809 | 2396 | 2412 |
| 1ZME | CD:AB | PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR | *S. cerevisiae* | 70 | X | 2.5 | Homodimer | C | D | 2206 | 1114 | 1092 |
| 2A07 | FGHIJK:ABCD | Forkhead box protein P2 | *H. sapiens* | 93 | X | 1.9 | Homo 6-mer | F | G | 4531 | 2277 | 2255 |
| 2BNW | ABCD:EFGH | ORF OMEGA | *S. pyogenes* | 53 | X | 2.4 | Homodimer | A | B | 3642 | 1838 | 1804 |
| 2BNW | ABCD:EFGH | ORF OMEGA | *S. pyogenes* | 53 | X | 2.4 | Homodimer | B | C | 498 | 246 | 252 |
| 2BNW | ABCD:EFGH | ORF OMEGA | *S. pyogenes* | 53 | X | 2.4 | Homodimer | C | D | 3810 | 1890 | 1920 |
| 2BOP | A:B | PROTEIN E2 | *B. papillomavirus type 1* | 85 | X | 1.7 | Homodimer | A | B | 692 | 355 | 336 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | A | B | 1910 | 958 | 951 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | A | E | 2678 | 1252 | 1427 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | B | E | 89 | 42 | 47 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | B | F | 2117 | 988 | 1129 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | C | D | 1924 | 965 | 959 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | C | F | 405 | 200 | 205 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | C | F | 405 | 200 | 205 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | C | G | 2614 | 1211 | 1403 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | D | G | 49 | 23 | 25 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | D | H | 2022 | 954 | 1068 |
| 2BSQ | ABCDEFGH:IJ | TRAFFICKING PROTEIN A + TRAFFICKING PROTEIN B | *N. gonorrhoeae* | 146+77 | X | 3.0 | Hetero 8-mer | E | H | 2743 | 1374 | 1369 |
| 2C62 | AB:C | ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15 | *H. sapiens* | 66 | X | 1.7 | Homo 2-mer | A | B | 2872 | 1434 | 1438 |
| 2C9L | YZ:AB | BZLF1 TRANS-ACTIVATOR PROTEIN | *E. virus* | 63 | X | 2.2 | Homo 2-mer | Y | Z | 2869 | 1395 | 1474 |
| 2ER8 | ABCD:EFGH | Regulatory protein LEU3 | *S. cerevisiae* | 72 | X | 2.8 | Homodimer | A | B | 0 | 0 | 0 |
| 2NLL | AB:CD | RETINOIC ACID RECEPTOR + THYROID HORMONE RECEPTOR | *H. sapiens* | 103+66 | X | 1.9 | Hetero 2-mer | A | B | 505 | 288 | 217 |
| 2OR1 | LR:AB | 434 REPRESSOR | *E. phage 434* | 69 | X | 2.5 | Homo 2-mer | L | R | 648 | 335 | 313 |
| 2P5L | CDGH:ABEF | Arginine repressor | *B. subtilis* | 64 | X | 2.8 | Homodimer | C | D | 1003 | 504 | 498 |
| 2QL2 | ABCD:EFGH | Neurogenic differentiation factor 1 | *M. musculus* | 60 | X | 2.5 | Homo 2-mer | A | B | 1891 | 947 | 944 |
| 2R1J | LR:BA | Repressor protein C2 | *S. phage P22* | 68 | X | 1.5 | Homo 2-mer | L | R | 732 | 367 | 364 |
| 2RBF | AB:CD | Bifunctional protein putA | *E. coli* | 54 | X | 2.2 | Homodimer | A | B | 3240 | 1591 | 1648 |
| 2VY1 | A:W | PROTEIN LEAFY | *A. thaliana* | 194 | X | 2.1 | Homodimer | A | B | 650 | 325 | 325 |
| 2W7N | AB:EFGH | TRFB TRANSCRIPTIONAL REPRESSOR PROTEIN | *E. coli* | 101 | X | 1.8 | Homodimer | A | B | 2118 | 1080 | 1038 |
| 2YPA | ABCD:EF | LIM DOMAIN-BINDING PROTEIN 1 + RHOMBOTIN-2 + T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 + TRANSCRIPTION FACTOR E2-ALPHA | *H. sapiens* | 145+51+ 82+91 | X | 2.8 | Hetero 4-mer | A | B | 2208 | 1130 | 1078 |
| 2YPA | ABCD:EF | LIM DOMAIN-BINDING PROTEIN 1 + RHOMBOTIN-2 + T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 + TRANSCRIPTION FACTOR E2-ALPHA | *H. sapiens* | 145+51 +82+91 | X | 2.8 | Hetero 4-mer | A | C | 1251 | 616 | 635 |
| 2YPA | ABCD:EF | LIM DOMAIN-BINDING PROTEIN 1 + RHOMBOTIN-2 + T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 + TRANSCRIPTION FACTOR E2-ALPHA | *H. sapiens* | 145+51 +82+91 | X | 2.8 | Hetero 4-mer | B | C | 671 | 354 | 316 |
| 2YPA | ABCD:EF | LIM DOMAIN-BINDING PROTEIN 1 + RHOMBOTIN-2 + T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 + TRANSCRIPTION FACTOR E2-ALPHA | *H. sapiens* | 145+51+ 82+91 | X | 2.8 | Hetero 4-mer | C | D | 3372 | 1575 | 1797 |
| 2YVH | ABCD:EFGH | Transcriptional regulator | *C. glutamicum* | 177 | X | 2.5 | Homodimer | A | B | 3711 | 1886 | 1824 |
| 2ZHG | A:B | Redox-sensitive transcriptional activator soxR | *E. coli* | 154 | X | 2.8 | Homodimer | A | C | 3213 | 1607 | 1607 |
| 3A5T | AB:CD | Transcription factor MafG | *M. musculus* | 107 | X | 2.8 | Homodimer | A | B | 1786 | 856 | 930 |
| 3CLC | ABCD:EF | Regulatory protein | *E. sp. RFL1396* | 82 | X | 2.8 | Homodimer | A | B | 1895 | 965 | 931 |
| 3CLC | ABCD:EF | Regulatory protein | *E. sp. RFL1396* | 82 | X | 2.8 | Homodimer | B | C | 181 | 90 | 91 |
| 3CLC | ABCD:EF | Regulatory protein | *E. sp. RFL1396* | 82 | X | 2.8 | Homodimer | C | D | 1913 | 937 | 975 |
| 3D2W | A:B | TAR DNA-binding protein 43 | *M. musculus* | 89 | X | 1.6 | Homodimer | A | C | 0 | 0 | 0 |
| 3DNV | AB:T | HTH-type transcriptional regulator hipB + Protein hipA | *E. coli* | 440+88 | X | 2.6 | Heterodimer | A | B | 1036 | 515 | 521 |
| 3DNV | AB:T | HTH-type transcriptional regulator hipB + Protein hipA | *E. coli* | 440+88 | X | 2.6 | Heterodimer | A | D | 686 | 350 | 336 |
| 3DNV | AB:T | HTH-type transcriptional regulator hipB + Protein hipA | *E. coli* | 440+88 | X | 2.6 | Heterodimer | B | C | 686 | 336 | 350 |
| 3DNV | AB:T | HTH-type transcriptional regulator hipB + Protein hipA | *E. coli* | 440+88 | X | 2.6 | Heterodimer | B | D | 2804 | 1402 | 1402 |
| 3DNV | AB:T | HTH-type transcriptional regulator hipB + Protein hipA | *E. coli* | 440+88 | X | 2.6 | Heterodimer | C | D | 1036 | 515 | 521 |
| 3E6C | C:BA | Cyclic nucleotide-binding protein | *D. hafniense* | 250 | X | 1.8 | Homodimer | C | F | 4649 | 2325 | 2325 |
| 3FDQ | AB:CD | Motility gene repressor mogR | *L. monocytogenes serovar 1/2a* | 170 | X | 1.7 | Homodimer | A | B | 307 | 154 | 153 |
| 3GFI | AC:DE | 146aa long hypothetical transcriptional regulator | *S. tokodaii* | 146 | X | 2.1 | Homodimer | A | C | 5631 | 2832 | 2799 |
| 3GNA | A:DE | V(D)J recombination-activating protein 1 | *M. musculus* | 96 | X | 2.4 | Homodimer | A | B | 3723 | 1861 | 1861 |
| 3GXQ | AB:CD | Putative regulator of transfer genes ArtA | *S. aureus* | 54 | X | 2.3 | Homodimer | A | B | 3305 | 1641 | 1663 |
| 3GZ6 | AB:DC | MutT/nudix family protein | *S. oneidensis* | 240 | X | 2.9 | Heterodimer | A | B | 1987 | 992 | 995 |
| 3H0D | AB:DC | CtsR | *G. stearothermophilus* | 155 | X | 2.4 | Homodimer | A | B | 2166 | 1062 | 1104 |
| 3HTS | B:A | HEAT SHOCK TRANSCRIPTION FACTOR | *K. lactis* | 102 | X | 1.7 | Homodimer | B | D | 764 | 382 | 382 |
| 3IGM | BA:WXCD | PF14\_0633 protein | *P. falciparum* | 77 | X | 2.2 | Homodimer | A | B | 3100 | 1556 | 1544 |
| 3IKT | AB:CD | Redox-sensing transcriptional repressor rex | *T. thermophilus* | 207 | X | 2.2 | Homodimer | A | B | 5174 | 2567 | 2607 |
| 3IV5 | AB:CD | DNA-binding protein fis | *E. coli* | 98 | X | 2.9 | Homodimer | A | B | 4446 | 2220 | 2226 |
| 3JSO | AB:CD | LexA repressor | *E. coli* | 202 | X | 2.2 | Homodimer | A | B | 2810 | 1382 | 1428 |
| 3KS8 | ABCD:EF | Polymerase cofactor VP35 | *R. ebolavirus* | 184 | X | 2.4 | Homo 2-mer | A | B | 682 | 366 | 316 |
| 3LSP | A:BD | DesT | *P. aeruginosa* | 220 | X | 2.6 | Homodimer | A | C | 3083 | 1542 | 1542 |
| 3MLN | ABE:CD | Transcription factor COE1 | *M. musculus* | 224 | X | 2.4 | Homodimer | A | B | 584 | 290 | 294 |
| 3MZH | AB:CD | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY) | *M. tuberculosis* | 225 | X | 2.9 | Homo 2-mer | A | B | 3442 | 1717 | 1725 |
| 3N4M | ABC:DE | Catabolite gene activator + DNA-directed RNA polymerase subunit alpha | *E. coli* | 209+84 | X | 2.9 | Hetero 6-mer | A | B | 697 | 331 | 366 |
| 3N4M | ABC:DE | Catabolite gene activator + DNA-directed RNA polymerase subunit alpha | *E. coli* | 209+84 | X | 2.9 | Hetero 6-mer | B | C | 319 | 138 | 181 |
| 3O9X | AB:FE | Uncharacterized HTH-type transcriptional regulator ygiT | *E. coli* | 133 | X | 2.1 | Homo 2-mer | A | B | 1615 | 804 | 811 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | A | B | 1231 | 616 | 615 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | A | C | 2703 | 1319 | 1384 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | A | D | 5589 | 2820 | 2769 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | B | C | 5743 | 2901 | 2842 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | B | D | 2535 | 1245 | 1291 |
| 3ON0 | ABCD:P | Protein traM | *E. coli* | 127 | X | 2.8 | Homotetramer | C | D | 920 | 466 | 454 |
| 3Q5F | AB:CD | Transcriptional regulator slyA | *S. typhimurium* | 147 | X | 2.9 | Homodimer | A | B | 4248 | 2107 | 2141 |
| 3R2C | ABJK:RS | 30S ribosomal protein S10 + N utilization substance protein B | *A. aeolicus* | 148+83 | X | 1.9 | Heterodimer | A | J | 1682 | 855 | 827 |
| 3U3W | ABPQ:YZ | C-terminus heptapeptide from PapR protein + Transcriptional activator PlcR protein | *B. thuringiensis* | 293+7 | X | 2.4 | Heterodimer | A | B | 3782 | 1886 | 1897 |
| 3VOK | A:U | Transcriptional regulator | *L. lactis subsp. lactis* | 189 | X | 2.0 | Homodimer | A | B | 3147 | 1574 | 1574 |
| 3ZKC | AB:CD | HTH-TYPE TRANSCRIPTIONAL REGULATOR SINR | *B. subtilis* | 111 | X | 3.0 | Homodimer | A | B | 1038 | 525 | 513 |
| 3ZPL | ABEF:CDGH | PUTATIVE MARR-FAMILY TRANSCRIPTIONAL REPRESSOR | *S. coelicolor* | 177 | X | 2.8 | Homodimer | A | B | 5268 | 2631 | 2636 |
| 3ZQL | ABCD:EFGH | PUTATIVE REPRESSOR SIMREG2 | *S. antibioticus* | 267 | X | 2.9 | Homodimer | C | D | 5201 | 2588 | 2613 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | E | B | 443 | 237 | 206 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | E | A | 1982 | 1048 | 934 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | E | H | 3198 | 1587 | 1611 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | F | B | 2881 | 1580 | 1301 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | F | C | 450 | 249 | 200 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | F | G | 3402 | 1698 | 1703 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | F | A | 1041 | 568 | 473 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | F | D | 6 | 3 | 3 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | H | B | 12 | 6 | 6 |
| 3ZVK | ABCDEFGH:XY | ANTITOXIN OF TOXIN-ANTITOXIN SYSTEM VAPB + TOXIN OF TOXIN-ANTITOXIN SYSTEM | *R. felis* | 134+78 | X | 2.5 | Hetero 8-mer | H | D | 1538 | 825 | 713 |
| 4EGY | AB:TU | Arabinose metabolism transcriptional repressor | *B. subtilis* | 88 | X | 2.3 | Monomer | A | B | 91 | 45 | 46 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | A | C | 3878 | 1981 | 1898 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | A | D | 88 | 48 | 40 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | B | C | 508 | 266 | 242 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | B | D | 2347 | 1137 | 1211 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | C | D | 17344 | 8787 | 8557 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | C | F | 4746 | 2409 | 2337 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | D | E | 4565 | 2358 | 2206 |
| 4G7H | ABCDEFKLMNOP: GHQR | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor | *T. thermophilus* | 1119+1524+ 315+443+99 | X | 2.9 | Hetero 6-mer | D | F | 7636 | 3834 | 3802 |
| 4G92 | ABC:DE | HAPB protein + HapE + Transcription factor HapC (Eurofung) | *E. nidulans* | 119+64+92 | X | 1.8 | Hetero 3-mer | A | B | 1630 | 867 | 763 |
| 4G92 | ABC:DE | HAPB protein + HapE + Transcription factor HapC (Eurofung) | *E. nidulans* | 119+64+92 | X | 1.8 | Hetero 3-mer | A | C | 787 | 390 | 397 |
| 4G92 | ABC:DE | HAPB protein + HapE + Transcription factor HapC (Eurofung) | *E. nidulans* | 119+64+92 | X | 1.8 | Hetero 3-mer | B | C | 5744 | 2893 | 2851 |
| 4H10 | AB:CD | Polymerase cofactor VP35 | *H. sapiens* | 146 | X | 2.4 | Heterodimer | A | B | 2005 | 1014 | 991 |
| 4HF1 | AB:CD | Aryl hydrocarbon receptor nuclear translocator-like protein 1 + Circadian locomoter output cycles protein kaput | *E. coli* | 71+73 | X | 2.2 | Homodimer | A | B | 3424 | 1724 | 1700 |
| 4HQE | AB:CD | Transcriptional regulator QsrR | *S. aureus* | 115 | X | 2.3 | Homodimer | A | B | 4509 | 2250 | 2259 |
| 4HQU | A:C | Platelet-derived growth factor subunit B | *H. sapiens* | 109 | X | 2.2 | Homodimer | A | B | 2206 | 1103 | 1103 |
| 4I2O | AB:WX | FixK2 protein | *B. japonicum* | 243 | X | 1.7 | Homodimer | A | B | 4252 | 2119 | 2133 |
| 4IHT | ABCD:EFGH | HTH-type transcriptional regulator BenM | *A. baylyi* | 94 | X | 3.0 | Homodimer | A | B | 2378 | 1214 | 1164 |
| 4IQR | ABEFIJKL:CDGH | Hepatocyte nuclear factor 4-alpha + Nuclear receptor coactivator 2 | *H. sapiens* | 13+338 | X | 2.9 | Homodimer | A | B | 3813 | 1845 | 1968 |
| 4IZZ | AB:CD | Transcription Factor HetR | *F. thermalis PCC 7521* | 302 | X | 2.5 | Homodimer | A | B | 14328 | 7139 | 7190 |
| 4J19 | AB:CD | Homeobox-containing protein 1 | *H. sapiens* | 113 | X | 2.9 | Monomer | A | B | 189 | 93 | 96 |
| 4JCX | AB:CD | Csp231I C protein | *C. sp. RFL231* | 98 | X | 2.3 | Homodimer | A | B | 2337 | 1164 | 1173 |
| 4JL3 | ABCD:EF | Transcriptional regulator, TetR family | *M. smegmatis* | 196 | X | 2.5 | Homodimer | A | B | 0 | 0 | 0 |
| 4KFC | AB:YZ | KDP operon transcriptional regulatory protein KdpE | *E. coli* | 227 | X | 2.5 | Homodimer | A | B | 2201 | 1089 | 1112 |
| 4LDX | AB:CD | Auxin response factor 1 | *A. thaliana* | 363 | X | 2.9 | Homodimer | A | B | 2379 | 1181 | 1197 |
| 4LLN | ABCDIJ:GHEFKL | MepR | *S. aureus* | 140 | X | 2.8 | Homodimer | A | B | 4218 | 2082 | 2136 |
| 4MTD | ABCD:YZ | Zinc uptake regulation protein | *E. coli* | 171 | X | 2.5 | Homodimer | A | B | 403 | 201 | 202 |
| 4NHJ | AB:CD | DNA-binding transcriptional regulator RstA | *K. pneumoniae subsp. pneumoniae* | 119 | X | 2.7 | Homodimer | A | B | 723 | 334 | 389 |
| 4ON0 | ABCD:EGFH | NolR | *R. fredii* | 118 | X | 3.0 | Homodimer | A | B | 2766 | 1372 | 1395 |
| 4R22 | B:G | HTH-type transcriptional regulator TnrA | *P. megaterium* | 82 | X | 2.6 | Homodimer | A | B | 988 | 494 | 494 |
| 4RB1 | AB:D | DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport (Fur family) | *M. gryphiswaldense* | 145 | X | 2.7 | Heterodimer | A | B | 2215 | 1114 | 1101 |
| 4ROC | AB:NT | TATA-box-binding protein + Transcription factor IIIB 50 kDa subunit | *H. sapiens* | 183+360 | X | 1.9 | Hetero dimer | A | B | 3991 | 1966 | 2025 |
| 4WLS | AB:XYUV | HTH-type transcriptional regulator CueR | *E. coli* | 128 | X | 2.1 | Homodimer | A | B | 3248 | 1626 | 1622 |
| 4WU4 | AB:GH | Response regulator receiver domain protein | | 68 | X | 2.3 | Homodimer | A | B | 872 | 437 | 435 |
| 5D8C | AB:CD | MerR family regulator protein | *H. influenzae* | 137 | X | 2.2 | Homodimer | A | B | 3464 | 1728 | 1737 |
| 5DY0 | ABCD:EFGH | TetR family transcriptional regulator | | 230 | X | 3.0 | Homodimer | A | B | 1617 | 803 | 814 |
| 5F7Q | CEJL:FK | Lmo0178 protein | *L. monocytogenes serovar 1/2a* | 407 | X | 2.4 | Homodimer | C | E | 4298 | 2152 | 2146 |
| 5FMP | AB:CD | HTH-TYPE TRANSCRIPTIONAL REPRESSOR KSTR | *M. tuberculosis* | 205 | X | 2.2 | Homodimer | A | B | 2736 | 1369 | 1367 |
| 5GNJ | GIABEFMN: KLCDHJOP | Transcription factor MYC2 | *A. thaliana* | 89 | X | 2.7 | Homodimer | A | B | 3312 | 1635 | 1678 |
| 5GPC | ABCD:GE | Transcriptional regulator (TetR/AcrR family) | *H. halodurans* | 194 | X | 2.8 | Homodimer | A | B | 3523 | 1759 | 1764 |
| 5H3R | AB:CD | Multiple antibiotic resistance protein MarR | *E. coli* | 147 | X | 2.6 | Homodimer | A | B | 5783 | 2890 | 2893 |
| 5HLG | ABCDEFGH:IJKLMNP | MarR family transcriptional regulator | *S. epidermidis* | 148 | X | 3.0 | Homodimer | A | B | 5295 | 2669 | 2626 |
| 5HSO | ABCD:EF | Uncharacterized HTH-type transcriptional regulator Rv2887 | *M. tuberculosis* | 160 | X | 2.5 | Homodimer | A | B | 3811 | 1910 | 1901 |
| 5I44 | BADEGFHIJK: UTZRPW | Chromosome-anchoring protein RacA | *B. subtilis* | 69 | X | 2.6 | Homodimer | A | B | 280 | 140 | 140 |
| 5JUB | ABCD:XZ | ComS+Transcriptional regulator | *S. thermophilus* | 310+8 | X | 2.5 | Homodimer | A | B | 3750 | 1897 | 1852 |
| 5K5Q | CDABEF:PN | AspA | *S. sp. NOB8H2* | 92 | X | 2.6 | Heterodimer | A | B | 2927 | 1468 | 1459 |
| 5K7Z | ABCD:EF | Transcriptional regulator, TetR family | *M. xanthus* | 231 | X | 2.9 | Homo 2-mer | A | B | 2885 | 1436 | 1450 |
| 5LEJ | AB:CD | Listeriolysin regulatory protein | *L. monocytogenes serovar 1/2a* | 237 | X | 2.7 | Homodimer | A | B | 4921 | 2469 | 2451 |
| 5MHJ | AB:EF | Major viral transcription factor ICP4 | *H. herpesvirus 1* | 201 | X | 2.1 | Homodimer | A | B | 5693 | 2856 | 2837 |
| 5MPF | AB:EF | Grainyhead-like protein 1 homolog | *H. sapiens* | 238 | X | 2.9 | Homodimer | A | B | 432 | 216 | 216 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | J | T | 28 | 14 | 14 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | J | D | 1235 | 642 | 594 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | J | F | 1905 | 998 | 908 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | C | A | 3845 | 1879 | 1966 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | C | B | 441 | 216 | 225 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | C | D | 15437 | 7845 | 7592 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | C | E | 496 | 254 | 242 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | C | F | 4042 | 2048 | 1994 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | D | A | 98 | 48 | 50 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | D | B | 2266 | 1176 | 1090 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | D | E | 4150 | 2061 | 2089 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 22.7 | Hetero 9-mer | D | F | 4500 | 2257 | 2243 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | D | B | 2266 | 1176 | 1090 |
| 5TW1 | JABCDEFT:OP | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + RNA polymerase sigma factor SigA + RNA polymerase-binding protein RbpA + Unknown peptide | *M. smegmatis* | 107+114+1169+ 1317+17+350+ 466 | X | 2.7 | Hetero 9-mer | D | A | 98 | 48 | 50 |
| 5VL9 | ABCD:EFGH | Regulatory protein TetR | *E. lignolyticus* | 192 | X | 2.1 | Homodimer | A | B | 2981 | 1479 | 1503 |
| 5X11 | ABCDEFGH:IJMN | Transcriptional regulator | *B. spizizenii* | 188 | X | 2.6 | Homodimer | A | B | 6855 | 3433 | 3422 |
| 5X5L | ABEHMN:CDFG | AdeR | *A. baumannii* | 109 | X | 2.7 | Heterodimer | A | E | 578 | 273 | 305 |
| 5X5L | ABEHMN:CDFG | AdeR | *A. baumannii* | 109 | X | 2.7 | Heterodimer | A | H | 690 | 343 | 347 |
| 5X5L | ABEHMN:CDFG | AdeR | *A. baumannii* | 109 | X | 2.7 | Heterodimer | B | H | 725 | 347 | 379 |
| 5X5L | ABEHMN:CDFG | AdeR | *A. baumannii* | 109 | X | 2.7 | Heterodimer | B | E | 724 | 363 | 361 |
| 5X5L | ABEHMN:CDFG | AdeR | *A. baumannii* | 109 | X | 2.7 | Heterodimer | E | M | 22 | 11 | 12 |
| 5XFQ | ABEF:CD | PHD finger protein 1 + Peptide from Histone H3 | *M. musculus* | 13+336 | X | 2.4 | Homo 2-mer | A | B | 1420 | 722 | 698 |
| 5XSK | AB:DF | Hepatoma-derived growth factor | *R. norvegicus* | 120 | X | 2.8 | Homodimer | A | B | 5390 | 2690 | 2700 |
| 5YEJ | ABC:DFG | TetR family transcriptional regulator | *M. smegmatis* | 232 | X | 2.7 | Homodimer | B | C | 2017 | 1020 | 997 |
| 5YI2 | ABEFIJMN: CGKODPLH | Zinc transport transcriptional regulator | *L. lactis subsp. lactis* | 146 | X | 2.6 | Homodimer | A | B | 4454 | 2211 | 2242 |
| 5ZD4 | CDAB:GHEF | Maltose-binding periplasmic protein, Protein BRASSINAZOLE-RESISTANT 1 | *A. thaliana* | 453 | X | 2.1 | Homodimer | C | D | 3120 | 1562 | 1558 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | A | B | 3468 | 1730 | 1738 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | A | C | 944 | 497 | 447 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | A | F | 1113 | 623 | 490 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | A | E | 220 | 100 | 120 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | B | C | 3596 | 1886 | 1710 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | B | E | 464 | 232 | 232 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | B | D | 242 | 128 | 114 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | C | D | 1109 | 486 | 623 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | D | E | 3454 | 1713 | 1741 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | D | F | 926 | 491 | 435 |
| 5ZGN | ABCDEF:GH | KacA+KacT | *K. pneumoniae subsp. pneumoniae* | 177+88 | X | 2.2 | Hetero 6-mer | E | F | 3682 | 1944 | 1737 |
| 6C2S | ABCD:UVXY | Transcriptional regulator, MarR family | *R. palustris* | 186 | X | 2.8 | Homodimer | A | D | 5076 | 2557 | 2519 |
| 6C31 | ABCDEFGH:IJKL | TetR family transcriptional regulator | *M. tuberculosis* | 214 | X | 3.0 | Homodimer | A | B | 0 | 0 | 0 |
| 6C31 | ABCDEFGH:IJKL | TetR family transcriptional regulator | *M. tuberculosis* | 214 | X | 3.0 | Homodimer | B | C | 3052 | 1517 | 1535 |
| 6C31 | ABCDEFGH:IJKL | TetR family transcriptional regulator | *M. tuberculosis* | 214 | X | 3.0 | Homodimer | C | D | 0 | 0 | 0 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | A | B | 2688 | 1343 | 1345 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | A | D | 814 | 411 | 403 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | A | E | 1705 | 851 | 854 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | B | D | 1662 | 822 | 840 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | B | E | 918 | 456 | 462 |
| 6CG8 | ABDE:CF | UPF0335 protein B7Z12\_12435 | *C. vibrioides* | 78 | X | 2.3 | Homodimer | D | E | 2712 | 1356 | 1356 |
| 6CHV | ACBDGH:IJEFKL | Antitoxin HigA | *P. vulgaris* | 121 | X | 2.9 | Homodimer | A | C | 2693 | 1333 | 1360 |
| 6CRO | A:RU | LAMBDA CRO REPRESSOR | *E. phage lambda* | 60 | X | 3.0 | Homodimer | A | B | 1333 | 666 | 666 |
| 6HP7 | AB:CD | SPBc2 prophage-derived uncharacterized protein YopK | *B. subtilis* | 386 | X | 2.2 | Homodimer | A | B | 2721 | 1349 | 1372 |
| 6IDE | AB:CD | Transcriptional regulator LuxR family | | 256 | X | 2.5 | Homodimer | A | B | 6522 | 3251 | 3270 |
| 6JBX | AB:CD | Fatty acid biosynthesis transcriptional regulator | *S. pneumoniae* | 152 | X | 2.2 | Homodimer | A | B | 5140 | 2541 | 2600 |
| 6JGW | BA:CD | CadR | *P. putida* | 147 | X | 2.8 | Homodimer | A | B | 3665 | 1834 | 1831 |
| 6LB3 | ABCDEFGH:IJKLMN | HTH cro/C1-type domain-containing protein | *P. aeruginosa* | 109 | X | 2.5 | Homo 4-mer | A | B | 2880 | 1454 | 1427 |
| 6LXN | AB:CD | Transcriptional regulatory protein OmpR | *E. coli* | 113 | X | 2.9 | Homodimer | A | B | 497 | 266 | 231 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | A | B | 6166 | 3114 | 3052 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | A | C | 180 | 90 | 90 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | A | D | 1853 | 922 | 931 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | B | C | 1794 | 878 | 916 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | B | D | 156 | 78 | 78 |
| 6MRJ | ABCD:LM | Nickel-responsive regulator | *H. pylori* | 148 | X | 2.8 | Homo 4-mer | C | D | 6557 | 3236 | 3321 |
| 6NSM | ABCD:LM | TetR family transcriptional regulator CifR | *P. aeruginosa* | 198 | X | 2.8 | Homodimer | A | B | 3549 | 1769 | 1781 |
| 6ON0 | AB:CN | Gp39 | *R. N15* | 71 | X | 1.6 | Homodimer | A | B | 1389 | 696 | 693 |
| 6P0S | ABE:CD | DNA-binding protein Fis+Excisionase | *E. phage lambda* | 55+98 | X | 2.7 | FiS Homodimer and Excisionase Monomer | A | B | 4072 | 2013 | 2059 |
| 6P1A | ABC:DEFG | Q protein | *E. phage 21* | 162 | X | 2.8 | Homo 2-mer | A | B | 312 | 182 | 131 |
| 6Q2B | AB:CD | MarR family transcriptional regulator | *L. monocytogenes serovar 1/2a* | 153 | X | 2.7 | Homodimer | A | B | 6602 | 3313 | 3288 |
| 6QFD | ABCD:EFGH | DNA-binding protein | *H. salinarum* | 116 | X | 2.1 | Hetero 2-merHeterodimer | A | B | 4144 | 2067 | 2077 |
| 6RYD | ABEF:CDGH | Protein WUSCHEL | *A. thaliana* | 76 | X | 1.5 | Homodimer | E | F | 371 | 191 | 179 |
| 6W1A | AB:EF | Transcriptional regulator | *S. dysgalactiae* | 284 | X | 2.8 | Homodimer | A | B | 5332 | 2636 | 2696 |
| 6ZA3 | AB:EF | Transcriptional regulator, GntR family | *A. fabrum* | 250 | X | 2.0 | Homodimer | A | B | 2784 | 1372 | 1412 |
| 7AMN | BA:EF | HTH-type transcriptional regulator LuxR | *V. alginolyticus* | 221 | X | 2.3 | Homodimer | A | B | 3817 | 1889 | 1928 |
| 7B0C | AB:CD | HTH-type transcriptional repressor NsrR | *S. coelicolor* | 161 | X | 3.0 | Homodimer | A | B | 4176 | 2086 | 2090 |
| 7BCB | AB:CD | KORA domain-containing protein | *E. coli* | 110 | X | 2.8 | Homodimer | A | B | 2599 | 1322 | 1277 |
| 7BHY | ABC:EG | Deoxyribonucleoside regulator | *B. subtilis* | 57 | X | 2.3 | Homodimer | A | B | 1303 | 645 | 658 |
| 7BZG | ABEFIJ:CDGHKL | HTH-type transcriptional activator HxlR | *B. subtilis* | 123 | X | 2.9 | Homodimer | A | B | 3439 | 1705 | 1733 |
| 7C0G | AB:CD | Aca1 | *P. phage JBD30* | 79 | X | 2.4 | Homo 2-mer | A | B | 1305 | 655 | 650 |
| 7C9O | ABC:DE | Nuclear transcription factor Y subunit B-11 + Nuclear transcription factor Y subunit C-2+ Zinc finger protein HD1 | *O. sativa subsp. japonica* | 104+67+95 | X | 2.5 | trimer | A | B | 974 | 491 | 483 |
| 7C9O | ABC:DE | Nuclear transcription factor Y subunit B-11+Nuclear transcription factor Y subunit C-2+Zinc finger protein HD1 | *O. sativa subsp. japonica* | 104+67+95 | X | 2.5 | trimer | A | C | 1288 | 656 | 632 |
| 7C9O | ABC:DE | Nuclear transcription factor Y subunit B-11 + Nuclear transcription factor Y subunit C-2 + Zinc finger protein HD1 | *O. sativa subsp. japonica* | 104+67+95 | X | 2.5 | trimer | B | C | 4680 | 2323 | 2356 |
| 7DVV | AB:LM | HTH marR-type domain-containing protein | *S. agalactiae serotype III* | 153 | X | 2.4 | Homodimer | A | B | 3753 | 1851 | 1902 |
| 7EL3 | AB:CD | Homoprotocatechuate degradation operon regulator HpaR | *A. baumannii* | 141 | X | 1.7 | Homodimer | A | B | 4541 | 2276 | 2265 |
| 7EOF | BA:CD | Coiled-coil domain-containing protein 25 | *H. sapiens* | 204 | X | 2.7 | Homo 2-mer | A | B | 1855 | 932 | 924 |
| 7F2F | AB:EH | Serine-rich protein TYE7 | *S. cerevisiae* | 136 | X | 2.5 | Homodimer | A | B | 3119 | 1581 | 1538 |
| 7F9H | AB:CD | EnrR repressor | *E. piscicida* | 90 | X | 1.7 | Monomer | A | B | 273 | 136 | 138 |
| 7JNP | AB:CD | HTH-type transcriptional regulator MtrR | *N. gonorrhoeae* | 213 | X | 2.6 | Homodimer | A | B | 3461 | 1737 | 1724 |
| 7PZA | AB:CDEF | Putative cAMP-binding protein-catabolite gene activator | *R. meliloti* | 244 | X | 2.7 | Homodimer | A | B | 3807 | 1909 | 1898 |
| 7T8K | AB:CD | BrxR | *A. sp. NEB 394* | 291 | X | 2.3 | Homodimer | A | B | 8071 | 4033 | 4038 |
| 7V6W | FBCAEMLIKNDJ: GHPO | Antitoxin + Putative mRNA interferase YoeB | *S. aureus* | 85+89 | X | 2.5 | Homodimer | A | B | 2798 | 1402 | 1396 |
| 7V6W | FBCAEMLIKNDJ: GHPO | Antitoxin + Putative mRNA interferase YoeB | *S. aureus* | 85+89 | X | 2.5 | Homodimer | C | D | 2800 | 1399 | 1400 |
| 7VJQ | AB:CD | anti-CRISPR-associated protein Aca2 | *P. phage ZF40* | 121 | X | 2.7 | Homodimer | A | B | 2306 | 1154 | 1152 |
| 7VP1 | AB:CD | Transcription factor TCP10 | *A. thaliana* | 107 | X | 2.9 | Homo 2-mer | A | B | 3906 | 1922 | 1984 |
| 7X5G | ABEF:CDGH | Nuclear factor erythroid 2-related factor 2+Transcription factor MafG | *H. sapiens* | 104+113 | X | 2.3 | Heterodimer | A | B | 2136 | 1072 | 1065 |
| 7XQ5 | AB:CD | Protein INO2 + Protein INO4 | *S. cerevisiae* | 73+75 | X | 2.2 | Heterodimer | A | B | 2549 | 1268 | 1280 |
| 7ZG5 | ABCD:EF | Acetyltransferase + DUF1778 domain-containing protein | *S. typhimurium* | 176+94 | X | 2 | Homodimer | C | D | 155 | 79 | 76 |
| 8B4B | WXYZ:LM | Cholera toxin transcriptional activator | *V. cholerae serotype O1* | 110 | X | 1.7 | Monomer tandem repeat | W | X | 521 | 262 | 259 |
| 8B4B | WXYZ:LM | Cholera toxin transcriptional activator | *V. cholerae serotype O1* | 110 | X | 1.7 | Monomer tandem repeat | Y | Z | 600 | 278 | 322 |
| 8EJO | AB:CD | Homeobox domain-containing protein | *O. anatinus* | 71 | X | 2.6 | Homodimer | A | B | 664 | 331 | 333 |
| 8HML | AB:DC | DNA-binding response OmpR family regulator | *S. erythraea* | 143 | X | 2.9 | Monomer tandem repeat | A | B | 469 | 234 | 235 |
| 8J0K | AB:CD | Transcription factor AP-2-alpha | *H. sapiens* | 219 | X | 2.1 | Homodimer | A | B | 5938 | 2982 | 2956 |
| 8K4L | A:C | Nuclear respiratory factor 1 | *H. sapiens* | 109 | X | 2.3 | Homodimer | A | B | 4781 | 2361 | 2420 |
| 8K86 | AB:CD | Nuclear factor interleukin-3-regulated protein | *H. sapiens* | 73 | X | 2.0 | Homodimer | A | B | 1717 | 861 | 855 |
| 8PW0 | A:B | Iron dependent repressor, putative | *D. radiodurans* | 148 | X | 2.2 | Homodimer | A | B | 1632 | 804 | 827 |
| 8UVK | AB:CD | DNA-binding response regulator | | 224 | X | 2.21.0 | Homodimer | A | B | 2428 | 1210 | 1218 |
| 8YEY | CA:DB | Activating signal cointegrator 1 | *H. sapiens* | 148 | X | 2 | Monomer | A | C | 1282 | 640 | 642 |
| 2K1N | ABCD:EF | AbrB family transcriptional regulator | *B. subtilis* | 55 | N | - | Homodimer | A | B | 4205 | 2054 | 2151 |
| **II. RNA-binding Transcription Factors** | | | | | | | | | | | | | | |
| | | | | | | | | | | | |
| 1C9S | ABCDEFGHIJK LMNOPQRSTUV:W | TRP RNA-BINDING ATTENUATION PROTEIN | *G. stearothermophilus* | 74 | X | 1.9 | Homo 11-mer | L | W | 1050 | 502 | 548 |
| 4GHA | ACEG:IJ | Polymerase cofactor VP35 | *O. marburgense* | 146 | N | - | Homo 4-mer | A | G | 722 | 347 | 375 |
| 4GHA | ACEG:IJ | Polymerase cofactor VP35 | *O. marburgense* | 146 | N | - | Homo 4-mer | A | C | 242 | 120 | 122 |
| 4GHA | ACEG:IJ | Polymerase cofactor VP35 | *O. marburgense* | 146 | N | - | Homo 4-mer | C | E | 720 | 374 | 347 |
| 4GHA | ACEG:IJ | Polymerase cofactor VP35 | *O. marburgense* | 146 | N | - | Homo 4-mer | E | G | 650 | 339 | 312 |
| 5M3H | ABCXY:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subunit + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens* | 28+728+ 776+797 | X | 2.5 | Hetero 5-mer | A | B | 17314 | 8765 | 8549 |
| 5M3H | ABCXY:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subunit + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens* | 28+728+ 776+797 | X | 2.5 | Hetero 5-mer | A | C | 3035 | 1486 | 1549 |
| 5M3H | ABCXY:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subunit + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens* | 28+728+ 776+797 | X | 2.5 | Hetero 5-mer | B | C | 14217 | 6926 | 7291 |
| 6FHI | ABCX:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subuni t + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens,Influenza A virus* | 738+776 +809+19 | N | - | Hetero 4-mer | A | B | 17535 | 8868 | 8667 |
| 6FHI | ABCX:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subuni t + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens,Influenza A virus* | 738+776 | N | - | Hetero 4-mer | A | C | 3478 | 1728 | 1750 |
| 6FHI | ABCX:RV | Polymerase acidic protein + Polymerase basic protein 2 + RNA-directed RNA polymerase catalytic subuni t + TYR-SER-PRO-THR-SEP-PRO | *H. sapiens,Influenza A virus* | +809+19 | N | - | Hetero 4-mer | B | C | 14327 | 6973 | 7354 |
| **III. DNA/RNA-binding Transcription Factors** | | | | | | | | | | | | | | |
| | | | | | | | | | | | |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | B | 19430 | 9582 | 9848 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | C | 690 | 342 | 348 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | D | 619 | 312 | 307 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | E | 4276 | 2099 | 2177 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | F | 3850 | 1962 | 1888 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | G | 1441 | 745 | 696 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | H | 3027 | 1509 | 1518 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | I | 3102 | 1555 | 1547 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | K | 1977 | 980 | 997 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | M | 189 | 104 | 85 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | A | W | 451 | 230 | 222 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | C | 3225 | 1611 | 1615 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | D | 565 | 272 | 293 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | F | 98 | 46 | 53 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | G | 72 | 37 | 35 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | H | 13 | 7 | 7 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | I | 3018 | 1545 | 1473 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | J | 3143 | 1452 | 1690 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | K | 1033 | 492 | 541 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | L | 1959 | 912 | 1046 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit + DNA-directed RNA polymerase subunit beta + RNA polymerase II subunit + RNA polymerase II subunit B12.5 + RNA polymerase II subunit B32 + RNA polymerase II third largest subunit B44, part of central core + RNA polymerase subunit ABC10-alpha + RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III + RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III + Spt4/5 complex component + Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | M | 1021 | 500 | 521 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit+DNA-directed RNA polymerase subunit+DNA-directed RNA polymerase subunit beta+RNA polymerase II subunit+RNA polymerase II subunit B12.5+RNA polymerase II subunit B32+RNA polymerase II third largest subunit B44, part of central core+RNA polymerase subunit ABC10-alpha+RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III+RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III+RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III+Spt4/5 complex component+Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | B | W | 730 | 358 | 372 |
| 5XOG | ABCDEFGHIJK LMW:TN | DNA-directed RNA polymerase subunit+DNA-directed RNA polymerase subunit+DNA-directed RNA polymerase subunit beta+RNA polymerase II subunit+RNA polymerase II subunit B12.5+RNA polymerase II subunit B32+RNA polymerase II third largest subunit B44, part of central core+RNA polymerase subunit ABC10-alpha+RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III+RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III+RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III+Spt4/5 complex component+Transcription elongation factor 1 homolog | *K. phaffii* | 115+118+1227+ 145+155+171+ 1743+186+214+ 304+72+83+85 | X | 3.0 | Hetero 14-mer | E | F | 184 | 103 | 82 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+1317+218+368 | X | 2.8 | Hetero 6-mer | A | C | 3851 | 1959 | 1892 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+1317+218+368 | X | 2.8 | Hetero 6-mer | A | D | 176 | 84 | 92 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+1317+218+368 | X | 2.8 | Hetero 6-mer | A | B | 3863 | 1978 | 1885 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+1317+218+368 | X | 2.8 | Hetero 6-mer | C | D | 17251 | 8778 | 8473 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | C | F | 3777 | 1836 | 1941 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | C | E | 526 | 267 | 259 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | D | F | 3854 | 1850 | 2003 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | D | E | 4263 | 2089 | 2174 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | B | D | 2569 | 1269 | 1299 |
| 5ZX2 | ABCDEF:GH | DNA-directed RNA polymerase subunit alpha + DNA-directed RNA polymerase subunit beta + DNA-directed RNA polymerase subunit beta' + DNA-directed RNA polymerase subunit omega + ECF RNA polymerase sigma factor SigH | *M. tuberculosis* | 110+1174+ 1317+218+368 | X | 2.8 | Hetero 6-mer | B | C | 411 | 208 | 203 |
**aPDB ID:** Four letter protein data bank ID; **bPDB Chain Id:** Chain Identifier from the PDB file; **cProtein:** Name of the biomolecules; **dSource Organisms:** Source of the sequence obtained from various organisms; **eProtein length:** Length of the amino acid sequence**; fExperimental Methods:** Biophysical methods used for the structure determination (X: X-ray, N:NMR); **gResolution (Å):** Resolution of the macromolecules; **hOligomeric State:** Total number of protein in a macromolecular complex; **iProtein 1:** First protein chain in the macromolcule; **jProtein2:** Second protein chain in the macromolecule; **kProtein-Protein:** Buried surface area of protein-protein interface; **lProtein 1:** Buried surface area.protein chain 1; **lBSA:** Buried surface area of protein chain 2.