Collective Transitions in Multicellular Systems

Source: https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra1-collective-transitions-in-multicellular-systems Parent: https://physics-of-life.tu-dresden.de/

Research Avenue 1

Collective Transitions in Multicellular Systems

Tissue and organ formation relies on a hierarchy of processes that perform specific functions. These processes depend on tissue morphology, topology, as well as on physical and chemical characteristics. Physical and geometric tissue characteristics emerge from collective cellular behaviors and often involve qualitative changes in their collective states. These changes can be understood as collective transitions arising from cellular interactions and feedback.

Our aim is to reveal the physical principles that underlie the emergence of functional structures in living tissues. From a biological perspective, we will establish how tissue structure and function emerge from cell behaviors and their interactions. To achieve this result, concepts for collective transitions involving topology, energetics, mechanics, electricity and chemistry in active materials will be developed. A particular focus will be on how collective transitions govern the spatiotemporal organization of multicellular systems.

Research Topic 1

Topological Morphogenesis

Research Topic 2

Mechano-Electro-Chemical Self-Organization

Research Topic 3

Spatiotemporal Control of Tissue Material Transitions

Research Topic 4

Energy Flows and Metabolic Patterning in Morphogenesis

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RA Leading Team

Anne Grapin-Botton (RA Leader)

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

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(RA Leader) in a new tab

Otger Campàs (RA Co-Leader)

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

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(RA Co-Leader)

Catherina G. Becker

TUD CRTD, TUD Faculty of Biology | Professor for Neural Development and Regeneration

Neural Development and Regeneration

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Rita Mateus

Research Group Leader

Biophysical Principles of Vertebrate Growth

hired by PoL

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PoL Groups

Elias Barriga

Research Group Leader

Biophysical Mechanisms of Morphogenesis

hired by PoL

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Catherina G. Becker

TUD CRTD, TUD Faculty of Biology | Professor for Neural Development and Regeneration

Neural Development and Regeneration

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Jan Brugués

Chair of Spatiotemporal Organization of Subcellular Structures

Spatiotemporal Organization of Subcellular Structures

hired by PoL

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Otger Campàs

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

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Adele Doyle

Research Group Leader

Mechanobiology of Stem Cells

hired by PoL

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Miki Ebisuya

Humboldt Professor and Chair of Cell and Tissue Control

Cross-Species Comparison and Manipulation of the Organoid Zoo

hired by PoL

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Elisabeth Fischer-Friedrich

Heisenberg Professor for Mechanics of Active Biomaterials

Mechanics of Active Biomaterials

hired by PoL

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Benjamin Friedrich

Heisenberg Professor for Biological Algorithms

Biological Algorithms: Spatio-Temporal Dynamics of Cells and Tissues

hired by PoL

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Anne Grapin-Botton

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

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Stephan W. Grill

MPI-CBG | Director of MPI-CBG, Professor for Physics of Life

Physics of Life

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Alf O. Honigmann

TUD BIOTEC | Professor for Biophysics

Membrane Organization of Cells and Tissues

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Meritxell Huch

MPI-CBG | Director of MPI-CBG, Lise Meitner Max Planck Research Group Leader

Organoids, tissue regeneration and its deregulation in disease

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Frank Jülicher

MPI-PKS | Director of MPI-PKS, Professor for Biophysics

Dynamic processes in cells and tissues

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Christina Kurzthaler

MPI-PKS, CSBD | Research Group Leader

Transport and Flows in Complex Environments

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Rita Mateus

Research Group Leader

Biophysical Principles of Vertebrate Growth

hired by PoL

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Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

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Carsten Werner

IPF | Professor for Biofunctional Polymer Materials

Biofunctional polymer materials

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Xingbo Yang

Research Group Leader

Bioenergetics of Self-Organization

hired by PoL

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PoL Associates

Sebastian Aland

HTWD | Professor for Numerical Analysis

Modeling and Simulation of Biological Interfaces

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Michael Brand

TUD CRTD | Professor for Developmental Genetics

Development and Regeneration of the Vertebrate Brain

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Christian Dahmann

TUD | Professor for Systems Biology and Genetics

Signals and mechanics in epithelial morphogenesis

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Carl Modes

MPI-CBG | Research Group Leader

Network Complexity and Systems Biophysics

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Benjamin Schumann

TUD | Professor of Biochemistry

Chemical Glycobiology

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Pavel Tomancak

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

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Jesse Veenvliet

MPI-CBG | Research Group Leader

Stembryogenesis

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