Organ Growth Control
Source: https://physics-of-life.tu-dresden.de/team/pol-groups/mateus/projects/organ-growth-control Parent: https://physics-of-life.tu-dresden.de/team/pol-groups/mateus
During animal development, organs need to grow in a proportional manner with respect to body size.
Our goal is to understand, in a quantitative way, how morphogens can regulate and contribute to organ growth.
Interestingly, during zebrafish pectoral fin development, we have found two BMP signalling gradients that are crucial to achieve pectoral fin proportionality. These are exponential concentration gradients that scale with the growing fin. Importantly, manipulation of the gradients leads to small fins.
By performing quantitative live imaging and generating new molecular tools, we are exploring the mechanisms that contribute to gradient scaling in vertebrates.
Future Projects and Goals
We want to investigate how information is converted into growth, in development and in regeneration, by looking into:
- Electrical ion flows – to study the propagation of ion flows as triggers for growth acceleration.
- Chemical signaling gradients – to test whether cells can detect the fold-change of morphogen concentration gradients over time.
- Mechanical forces – to investigate how growth anisotropy can link mechanical forces to stereotypical organ pattern.
More Information
Mateus R, Holtzer L, Seum C, Hadjivasiliou Z, Dubois M, Julicher F, Gonzalez-Gaitan M\ BMP signalling gradient scaling in the zebrafish pectoral fin\ Cell Reports 2020 30, 4292–4302
Brandão AS, Bensimon-Brito A, Lourenço R, Borbinha J, Soares AR, Mateus R, Jacinto A\ Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration\ Journal of Cell Science 2019 132: jcs231993