Dr. Dar-Bin Shieh-National Yang Ming Chiao Tung University

Source: https://www.nycu.edu.tw/nycu/en/app/artwebsite/view?module=artwebsite&id=35183&serno=75e1d095-2306-40ef-9408-a7a3103060d5 Parent: https://www.nycu.edu.tw/nycu/en/app/folder/627

Senior Vice President Dar-Bin Shieh

Current Position
Senior Vice President, NYCU
Professor, School of Dentistry, NYCU
Physician Scientist, Department of Medical Research, Taipei Veterans General Hospital
Contact
Phone：+886-2-2826-7201
Email：dbshieh@nycu.edu.tw
Staff
Office Coordinator： Ms. Chen
Phone： (03)571-2121 ext：62248
Email：phchen2@nycu.edu.tw

【Education】

Doctor of Medical Sciences (D.M.Sc), Harvard School of Dental Medicine, USA. (1991–1997)
Doctor of Dental Surgery (D.D.S.), National Yang-Ming University, Taiwan. (1982~1988)
Professional Experience
2021~ Chair Professor, Department of Dentistry and Institute of Oral Medicine, National Cheng Kung University
2010~ Distinguished Research Fellow, Centre for Micro/Nano Science and Technology, National Cheng Kung University
2013~2026.01 Director, International Institute of Macromolecular Analysis and Nanomedicine Innovations, National Cheng Kung University
2003~ Attending Physician and Session Chair, Department of Stomatology, National Cheng Kung University Hospital
2018~2020 Deputy Minister, Ministry of Science and Technology, Taiwan
2011~2020 Distinguished Professor, Institute of Oral Medicine, College of Medicine, National Cheng Kung University
2009~2014 Chairman, Institute of Oral Medicine, National Cheng Kung University
2008~2011 Professor, Institute of Oral Medicine, National Cheng Kung University
2007~2009 Director of University Development, Office of Research and Development, National Cheng Kung University

【Research Interest】

Oral diagnosis and pathology
Nanomedicine
Mitochondria medicine
Cryo-EM structural biology
Biomaterials
Molecular oncology
Biophotonics

【Honor】

2024 2024 Moderna Taiwan mRNA Innovation Awards
2023 2023 Future Tech Awards
2023 Contract Researcher, National Science and Technology Council
2021 2021 Future Tech Awards
2020 The 17th National Innovation Award- Renewal and Excelsior Award
2020 The 2020 Taipei Biotech Awards
2020 Outstanding Achievement Award from the Phi Tau Phi Honor Society of the Republic of China
2020 Academic Medical Contribution Award of Tainan Dental Association
2020 Special Contribution Award of the Republic of China Dental Association-Silver Award
2019 The 16th National Innovation Award- Renewal and Excelsior Award
2018 The 16th Y.Z. Hsu Chair Professor (Nano Science & Technology)
2018 J. D. Hou Outstanding Honor Award
2014 The Outstanding Research Award of Ministry of Science and Technology
2014 The 11th Outstanding Alumni Award of National Yang Ming University
2014 T. K. Lee Gold Medal Award
2014 2014 IEEE Tainan Section Outstanding Technical Achievement Award
2013 The 9th Nanotechnology Elite Award from Ministry of Economics
2011 The Outstanding Research Award of Ministry of Science and Technology
2011 The T. K. Lee Honorary Scholar Award

【Publications】

Ngamkham J, Chiangjong W, Wang PW, Shieh DB, Phansri T, Sritanaudomchai H. Synergistic enhancement of anticancer effects by periodontal ligament stem cell exosomes and oxaliplatin via apoptosis induction and protein modulation. Biomed Pharmacother. Published online August 19, 2025. doi:10.1016/j.biopha.2025.118481
Wei TY, Wu CC, Hsu YT, Lin WH, Tsai LC, Shieh DB, Chang CL. An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations. Gynecol Oncol. 2025 Aug;199:17-26. doi: 10.1016/j.ygyno.2025.06.006.
Hwu JR, Panja A, Tsay SC, Huang WC, Lin SY, Yeh CS, Su WC, Yang LX, Shieh DB. β-d-Ribofuranose as a Core with a Phosphodiester Moiety as the Enzyme Recognition Site for Codrug Development. Org Lett. 2024 Nov 22;26(46):9865-9870. doi: 10.1021/acs.orglett.4c03662. Epub 2024 Nov 14.
Tseng PC, Shieh DB, Kessler A, Kaisarly D, Rösch P, Kunzelmann KH. Direct ink writing with dental composites: A paradigm shift toward sustainable chair-side production. Dent Mater. Published online August 6, 2024. doi:10.1016/j.dental.2024.08.002
Hsieh CH, Ho PS, Wang WL, Shih FH, Hong CT, Wang PW, Shieh DB, Chang WL, Wang YC. Decreased plasma gelsolin fosters a fibrotic tumor micro-environment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma. J Biomed Sci. 31(1):90, Sep.2024
Yang LX, Lai YH, Cheung CI, Ye Z, Huang TC, Wang YC, Chin YC, Chia ZC, Chen YJ, Li MJ, Tseng HY, Tsai YT, Zhang ZB, Chen KH, Tsai BY, Shieh DB, Lee NY, Tsai PJ, Huang CC. Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity. Bioeng Transl Med. 2023 Sep 5;8(6):e10593. doi: 10.1002/btm2.10593.
Loke YL, Beishenaliev A, Wang PW, Lin CY, Chang CY, Foo YY, Faruqu FN, Leo BF, Misran M, Chung LY, Shieh DB, Kiew LV, Chang CC, Teo YY. ROS-generating alginate-coated gold nanorods as biocompatible nanosonosensitisers for effective sonodynamic therapy of cancer. Ultrason Sonochem. 2023 Jun;96:106437. doi: 10.1016/j.ultsonch.2023.106437.
Asare-Werehene M, Hunter RA, Gerber E, Reunov A, Brine I, Chang CY, Chang CC, Shieh DB, Burger D, Anis H, Tsang BK. The Application of an Extracellular Vesicle-Based Biosensor in Early Diagnosis and Prediction of Chemoresponsiveness in Ovarian Cancer. Cancers (Basel). 2023 Apr 30;15(9):2566. doi: 10.3390/cancers15092566.
Chiu CT, Cao JK, Wang PW, Wu YN, Lee YC, Jeng YR, Shieh DB, Reisz RR. Mammalian tooth enamel functional sophistication demonstrated by combined nanotribology and synchrotron radiation FTIR analyses. iScience. 2022 Dec 27;26(1):105679. doi: 10.1016/j.isci.2022.105679.
Shih TM, Hsiao JF, Shieh DB, Tsai GE. Acidic Microenvironment-Sensitive Core-Shell Microcubes: The Self-assembled and the Therapeutic Effects for Caries Prevention. Eur J Dent. 2022 Dec 19. doi: 10.1055/s-0042-1757464.
Hsieh CH, Kuan WH, Chang WL, Kuo IY, Liu H, Shieh DB, Liu H, Tan B, Wang YC. Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma. J Biomed Sci. 2022 Oct 30;29(1):90. doi: 10.1186/s12929-022-00873-4.
Kong B, Han CY, Kim SI, Patten DA, Han Y, Carmona E, Shieh DB, Cheung AC, Mes-Masson AM, Harper ME, Song YS, Tsang BK. Prohibitin 1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers. J Ovarian Res. 2022 Jun 7;15(1):70. doi: 10.1186/s13048-022-00999-x.
Wu YN, Yang LX, Wang PW, Braet F, Shieh DB. From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles. Pharmaceutics. 2022 Jan 2;14(1):99. doi: 10.3390/pharmaceutics14010099. (SCIE)
Yu CJ, Damaiyanti DW, Yan SJ, Wu CH, Tang MJ, Shieh DB, Liu PP, Liu PY. The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes. Int J Mol Sci. 2021 Dec 10;22(24):13281. doi: 10.3390/ijms222413281.
Tsai HY, Chao LC, Chou CH, Lin YH, Huang KC, Hsieh MC, Liao YT, Wang PW, Shieh DB. Enhanced fluorescence signal using stray light shutter in a quantitative PCR chip. Journal of Optics. 2021 Nov. (SCIE)
Wang PW, Lee WT, Wu YN, Shieh DB. Opportunities for Nanomedicine in Clostridioides difficile Infection. Antibiotics (Basel). 2021 Aug 5;10(8):948. doi: 10.3390/antibiotics10080948. (SCIE)
Hsieh CH, Hsieh HC, Shih FS, Wang PW, Yang LX, Shieh DB, Wang YC. An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment. Theranostics. 2021 May 13;11(14):7072-7091. doi: 10.7150/thno.57803. (SCIE)
Kiew LV, Chang CY, Huang SY, Wang PW, Heh CH, Liu CT, Cheng CH, Lu YX, Chen YC, Huang YX, Chang SY, Tsai HY, Kung YA, Huang PN, Hsu MH, Leo BF, Foo YY, Su CH, Hsu KC, Huang PH, Ng CJ, Kamarulzaman A, Yuan CJ, Shieh DB, Shih SR, Chung LY, Chang CC. Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors. Biosens Bioelectron. 2021 Jul 1;183:113213. doi: 10.1016/j.bios.2021.113213. Epub 2021 Apr 3. (SCIE)

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