Amelie Skopp

Source: https://cbr.cs.tum.de/en/team/personnel/amelie-skopp Parent: https://cbr.cs.tum.de/en/team/personnel

Curriculum

• Since 4/2022: Research assistant at the Chair of Chemistry of Biogenic Raw Materials
• 04/2019-03/2022: Research scientist at Aeglea Therapeutics, Inc., Austin, TX, USA\        Research area: Engineering of therapeutic human enzymes for the treatment of genetic diseases
• 05/2017-12/2018: Doctorate at the University of Texas at Dallas, Dallas, TX, USA. Principal Investigator Prof. Dr. Duane Winkler\        Dissertation topic: “Copper Trafficking to the Metalloenzyme SOD1”
• 08/2014-05/2017: Master's degree at the University of Texas at Dallas, Dallas, TX, USA\        Research area: “Structural studies of the histone chaperone FACT”
• 08/2011-06/2014: Bachelor's degree in Biochemistry and Cell Biology at Jacobs University Bremen\        Bachelor's thesis topic: “Applications of Biotechnological Methods to Investigate Endocytosis – A Theoretical and Practical Approach”

Research

• Bio-based coatings and paints
• Biohybrid catalytic materials
• Sensing and indicator materials
• Solid-state gas-phase catalysis
• Biotransformation
• Bioremediation

Publications

Skopp A, Boyd SD, Ullrich MS, Liu L, Winkler DD. Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1. Biometals. 2019 Aug;32(4):695-705. doi: 10.1007/s10534-019-00206-3. Epub 2019 Jul 10. PMID: 31292775

Boyd SD, Ullrich MS, Skopp A, Winkler DD. Copper Sources for Sod1 Activation. Antioxidants (Basel). 2020 Jun 7;9(6):500. doi: 10.3390/antiox9060500. PMID: 32517371

Boyd SD, Calvo JS, Liu L, Ullrich MS, Skopp A, Meloni G, Winkler DD. The yeast copper chaperone for copper-zinc superoxide dismutase (CCS1) is a multifunctional chaperone promoting all levels of SOD1 maturation. J Biol Chem. 2019 Feb 8;294(6):1956-1966. doi: 10.1074/jbc.RA118.005283. Epub 2018 Dec 10. PMID: 30530491

Winans S, Larue RC, Abraham CM, Shkriabai N, Skopp A, Winkler D, Kvaratskhelia M, Beemon KL. The FACT Complex Promotes Avian Leukosis Virus DNA Integration. J Virol. 2017 Mar 13;91(7):e00082-17. doi: 10.1128/JVI.00082-17. Print 2017 Apr 1. PMID: 28122976