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Title
Nelson Group -- Publications
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# Nelson Group -- Publications

**Source**: https://cmngroup.princeton.edu/publications.htm
**Parent**: https://cmngroup.princeton.edu/index.htm

princeton

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| **[research](research.htm)** | **[people](people.htm)** | **[publications](publications.htm)** | [**funding**](funding.htm) | **[news](news.htm)** | **[teaching](teaching.htm)**| [**outreach**](outreach.htm) | **[contact](contact.htm)** | [**home**](index.htm) | | |
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| ***Publications*** | | |
| Please note: Reprints are provided for personal use only. | | |
|  |  | 169. Banavar S.P., Fowler E.W., & Nelson C.M. (2024) Biophysics of morphogenesis in the vertebrate lung. *Curr. Topics Dev. Biol.,*  in press. |
|  |  | 168. Nelson C.M., Wickstrom S.A., Dufrene Y.F., Cosgrove D.J., Heisenberg C.-P., Dupont S., Shyer A.E., Rodriguez A.R., Trepat X., & Diz-Munoz A. (2024) Mechanobiology: Shaping the future of cellular form and function. *Cell,* 23: 2652-2656. [**[pdf]**](168_Nelson_Cell_2024.pdf) |
|  |  | 167. Anlas A.A. & Nelson C.M. (2024) Interplay between hormonal and mechanical signals in mammary morphodynamics. *Trends Cell Biol.,* 34: 434-436.  [**[pdf]**](167_Anlas_TrendsCellBiol_2024.pdf) |
|  |  | 166. Paramore S.V., Trenado Yuste C., Sharan R., Nelson C.M., & Devenport D.  (2024) Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation. *Dev. Cell,*  59: 1302-1316.  [**[pdf]**](166_Paramore_DevCell_2024.pdf) |
|  |  | 165. Leggett S.E., Brennan M.C., Martinez S., Tien J., & Nelson C.M. (2024) Relatively rare populations of invasive cells drive progression of heterogeneous tumors. *Cell. Mol. Bioeng.,*  17: 7-24.  [**[pdf]**](165_Leggett_CellMolBioeng_2024.pdf) |
|  |  | 164. Nerger B.A. & Nelson C.M. (2024) Bioprinting cell-laden hydrogels for studies of epithelial tissue morphogenesis. In *Tissue Morphogenesis (Methods in Molecular Biology),* (ed. Nelson C.M.), in press. |
|  |  | 163. Banavar S. &  Nelson C.M. (2023) Mechanical properties pattern the skin. *Science,* 382: 880. **[[pdf]](163_Banavar_Science_2023.pdf)** |
|  |  | 162. Lemma B. &  Nelson C.M. (2023) Spatial patterning of energy metabolism during tissue morphogenesis.  *Curr. Opin. Cell Biol.,* 85: 102235.  **[[pdf]](162_Lemma_CurrOpin_2023.pdf)** |
|  |  | 161. Farahani P.E., Yang X., Mesev E.V., Fomby K.A., Brumbaugh-Reed E.H., Bashor C.J., Nelson C.M., & Toettcher J.E. (2023) pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. *eLife,* 12: e82863. **[[pdf]](161_Farahani_eLife_2023.pdf)** |
|  |  | 160. Goodwin K. & Nelson C.M. (2023) Analysis of Cre lines for targeting airway smooth muscle. *Dev. Biol.,* 496: 63-72. [**[pdf]**](160_Goodwin_DevBiol_2023.pdf) |
|  |  | 159. Goodwin K., Lemma B., Zhang P., Boukind A., & Nelson C.M. (2023) Plasticity in airway smooth muscle differentiation during mouse lung development. *Dev. Cell,* 58: 338-347. [**[pdf]**](159_Goodwin_DevCell_2023.pdf)  *bioRxiv,* DOI: https://doi.org/10.1101/2022.05.27.493761 |
|  |  | 158. Dance Y.W., Obenreder M.C., Seibel A.J., Meshulam T., Ogony J.W., Lahiri N., Pacheco-Spann L., Radisky D.C., Layne M.D., Farmer S.R., Nelson C.M., Tien J. (2023) Adipose cells induce escape from an engineered human breast microtumor independently of their obesity status. *Cell. Mol. Bioeng.,* 16: 23-39. **[[pdf]](158_Dance_CellMolBioeng_2023.pdf)** |
|  |  | 157. Paramore S.V., Goodwin K., & Nelson C.M. (2022) How to build an epithelial tree. *Phys. Biol.,* 19: 061002. [**[pdf]**](157_Paramore_PhysBiol_2022.pdf) |
|  |  | 156. Seibel A.J., Kelly O.M., Dance Y.W., Nelson C.M., Tien J. (2022) Role of lymphatic endothelium in vascular escape of engineered human breast microtumors. *Cell. Mol. Bioeng.,* 15: 553-569. [**[pdf]**](156_Seibel_CellMolBioeng_2022.pdf) |
|  |  | 155. Goodwin K., Jaslove J.M., Tao H., Zhu M., Hopyan S., & Nelson C.M. (2022) Patterning the embryonic pulmonary mesenchyme. *iScience,* 25: 103838. *bioRxiv,* DOI: https://doi.org/10.1101/2020.08.20.259101 **[[pdf]](155_Goodwin_iScience_2022.pdf)** |
|  |  | 154. Nelson C.M. (2022) Mechanical control of cell differentiation: insights from the early embryo. *Annu. Rev. Biomed. Eng.,* 24: 307-322. [**[pdf]**](154_Nelson_ARBME_2022.pdf) |
|  |  | 153. Jaslove J.M., Goodwin K., Sundarakrishnan A., Spurlin J.W., Mao S., Kosmrlj A., & Nelson C.M. (2022) Transmural pressure signals through retinoic acid to regulate lung branching. *Development,* 149: dev199726. [**[pdf]**](153_Jaslove_Development_2022.pdf) |
|  |  | 152. Farahani P.E. & Nelson C.M. (2022) Revealing epithelial morphogenetic mechanisms through live imaging. *Curr. Opin. Genet. Dev.,*  72: 61-68. [**[pdf]**](152_Farahani_CurrOpinGenetDev_2022.pdf) |
|  |  | 151. Leggett S.E. & Nelson C.M. (2022) Tissue architecture in cancer initiation and progression. In *Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications,* (eds. Akslen R.A. and Watnick R.S.), 91-107. |
|  |  | 150. Brennan M.C. & Nelson C.M. (2022) Cell patterning to mimic tumor anatomy. In *Biomaterial based approaches to study the tumor microenvironment,* (eds. Winter J.O. and Rao S.), 163-196. |
|  |  | 149. Dance Y.W., Meshulam T., Seibel A.J., Obenreder M.C., Layne M.D., Nelson C.M., & Tien J. (2022) Adipose stroma accelerates the invasion and escape of human breast cancer cells from an engineered microtumor. *Cell. Mol. Bioeng.,* 15: 15-29. [**[pdf]**](149_Dance_CellMolBioeng_2022.pdf) |
|  |  | 148. Farahani P.E., Lemke S.B., Dine E., Uribe G., Toettcher J.E., & Nelson C.M. (2022) Substratum stiffness regulates Erk signaling dynamics through receptor-level control. *Cell Rep.,* 37: 110181. [**[pdf]**](148_Farahani_CellReports_2022.pdf) |
|  |  | 147. Palmer M.A., Nerger B.A., Goodwin K., Sudhakar A., Lemke S.B., Ravindran P., Toettcher J.E., Kosmrlj A., & Nelson C.M. (2021) Stress ball morphogenesis: how the lizard builds its lung. *Sci. Adv.,* 7: eabk0161. [**[pdf]**](147_Palmer_SciAdv_2021.pdf) |
|  |  | 146. Stanton A.E., Goodwin K., Sundarakrishnan A., Jaslove J.M., Gleghorn J.P., Pavlovich A.L., & Nelson C.M. (2021) Negative transpulmonary pressure suppresses airway morphogenesis by inhibiting FGF10. *Frontiers in Cell Dev. Biol.,*  9: 725785. [**[pdf]**](146_Stanton_Frontiers_2021.pdf) |
|  |  | 145. Lemke S.B. & Nelson C.M. (2021) How dynamic changes in epithelial cell packing shape tissues during morphogenesis. *Curr. Biol.,*  31: R1098-R1110. [**[pdf]**](145_Lemke_CurrBiol_2021.pdf) |
|  |  | 144. Silver B.B., Zhang S.X., Rabie E.M., & Nelson C.M. (2021) Substratum stiffness tunes membrane voltage in mammary epithelial cells*. J. Cell Sci.*, 134: jcs256313.[**[pdf]**](144_Silver_JCS_2021.pdf) |
|  |  | 143. Nelson C.M. (2021) The mechanics of crypt morphogenesis*. Nat. Cell Biol.*, 23: 678-679.[**[pdf]**](143_Nelson_NCB_2021.pdf) |
|  |  | 142. Rabie E.M., Zhang S.X., Dunn C.E., & Nelson C.M. (2021) Substratum stiffness signals through integrin-linked kinase and beta1-integrin to regulate midbody proteins and abscission during EMT*. Mol. Biol. Cell*, 32: 1664-1676. [**[pdf]**](142_Rabie_MBoC_2021.pdf) **[[supp]](142_Rabie_MBoC_2021supp.pdf)** |
|  |  | 141. Nerger B.A., Jaslove J.M., Elashal H., Mao S., Kosmrlj A., Link A.J., & Nelson C.M. (2021) Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland*. Curr. Biol.*, 31: 1903-1917.[**[pdf]**](141_Nerger_CurrBiol_2021.pdf) |
|  |  | 140. Leggett S.E. & Nelson C.M. (2021) Where is the EMT? Computer vision at the frontline of precision medicine*. Trends Cancer*, 7: 272.[**[pdf]**](140_Leggett_TrendsCancer_2021.pdf) |
|  |  | 139. Rabie E.M., Zhang S.X., Kourouklis A.P., Kilinc A.N., Simi A.K., Radisky D.C., Tien J., & Nelson C.M. (2021) Matrix degradation and proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. *Integr. Biol.,* 13: 17-29.**[[pdf]](139_Rabie_IntegrBiol_2021.pdf)**[[cover]](139_Rabie_IntegrBiol_2021cover.jpg)**** |
|  |  | 138. Kilinc A.N., Han S., Barrett L.A., Anandasivam M. & Nelson C.M. (2021) Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFbeta1. *Mol. Biol. Cell,* 32: 402-412. [**[pdf]**](138_Kilinc_MBoC_2021.pdf) |
|  |  | 137. Goodwin K. & Nelson C.M. (2021) Mechanics of development. *Dev. Cell,* 20: 30934-5. [**[pdf]**](137_Goodwin_DevCell_2020.pdf) |
|  |  | 136. Goodwin K. & Nelson C.M. (2021) Uncovering cellular networks in branching morphogenesis using single-cell transcriptomics. *Curr. Topics Dev. Biol.,* 143: 239-280. [**[pdf]**](136_Goodwin_CurrTopics_2021.pdf) |
|  |  | 135. Tien J., Dance Y.W., Ghani U., Seibel A.J., & Nelson C.M. (2021) Interstitial hypertension suppresses escape of human breast tumor cells via convection of interstitial fluid. *Cell Mol. Bioeng.,* 14: 147-159. [**[pdf]**](135_Tien_CellMolBioeng_2020.pdf)**[[cover]](135_Tien_CellMolBioeng_2020_cover.pdf)** |
|  |  | 134. Tien J., Ghani U., Dance Y.W., Seibel A.J., Karakan M.C., Ekinci K.L., & Nelson C.M. (2020) Matrix pore size governs escape of human breast cancer cells from a microtumor to an empty cavity. *iScience,* 23: 101673. [**[pdf]**](134_Tien_iScience_2020.pdf) |
|  |  | 133. Anlas A.A. & Nelson C.M. (2020) Living under strain: how epithelia protect their genomes from repeated stretching. *Biochemistry,* 4: 2761-2763. [**[pdf]**](133_Anlas_Biochemistry_2020.pdf) |
|  |  | 132. Anlas A.A. & Nelson C.M. (2020) Soft microenvironments induce chemoresistance by increasing autophagy downstream of integrin-linked kinase. *Cancer Res.,* 80: 4103-4113. [**[pdf]**](132_Anlas_CancerRes_2020.pdf) |
|  |  | 131. Silver B.B., Wolf A.E., Lee J., Pang M.-F., & Nelson C.M. (2020) Epithelial tissue geometry drives emergence of bioelectric field and pattern of proliferation. *Mol. Biol. Cell,* 31: 1691-1702.**[[pdf]](131_Silver_MBoC_2020.pdf)[[cover]](131_Silver_MBoC_2020_cover.pdf)** |
|  |  | 130. Palmer M.A. & Nelson C.M. (2020) Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia. *Dev. Dyn.,* 249: 1318-1333. [**[pdf]**](130_Palmer_DevDyn_2020.pdf) |
|  |  | 129. Nerger B.A., Brun P.-T., & Nelson C.M. (2020) Marangoni flows drive the alignment of fibrillar cell-laden hydrogels. *Science Adv.,* 6(24): eazz7748.**[[pdf]](129_Nerger_SciAdv_2020.pdf)** |
|  |  | 128. Goodwin K. & Nelson C.M. (2020) Branching morphogenesis. *Development,* 147: dev184499.[**[pdf]**](128_Goodwin_Development_2020.pdf) |
|  |  | 127. Nerger B.A. & Nelson C.M. (2020) Engineered extracellular matrices: emerging strategies for decoupling structural and molecular signals that regulate epithelial branching morphogenesis. *Curr. Opin. Biomed. Eng.,* 13: 103-112. [**[pdf]**](127_Nerger_COBME_2020.pdf) |
|  |  | 126. Goodwin K., Mao S., Guyomar T., Miller E., Radisky D.C., Kosmrlj A., & Nelson C.M. (2019) Smooth muscle differentiation shapes domain branches during mouse lung development. *Development,* 146: dev182188. [**[pdf]**](126_Goodwin_Development_2019.pdf) |
|  |  | 125. Spurlin J.W. III, Siedlik M.J., Nerger B.A., Pang M.F., Jayaraman S., Zhang R., & Nelson C.M. (2019) Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung. *Development,* 146: dev175257. [**[pdf]**](125_Spurlin_Development_2019.pdf) |
|  |  | 124. Nerger B.A., Brun P.T., & Nelson C.M. (2019) Microextrusion printing cell-laden networks of type I collagen with patterned anisotropy and geometry. *Soft Matter,* 15: 5728-5738. [**[pdf]**](124_Nerger_SoftMatter_2019.pdf) *BioRxiv,* DOI: https://doi.org/10.1101/509265 |
|  |  | 123. Lehmann R., Lee C.M., Shugart E.C., Benedetti M., Charo R.A., Gartner Z., Hogan B., Knoblich J., Nelson C.M., & Wilson K.M. (2019) Human organoids: a new dimension in cell biology*. Mol. Biol. Cell,* 30: 1129-1137. [**[pdf]**](123_Lehmann_MBoC_2019.pdf) |
|  |  | 122. Nerger B.A. & Nelson C.M. (2019) 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung. *Biomaterials,* 198: 135-145. [**[pdf]**](122_Nerger_Biomaterials_2019.pdf) |
|  |  | 121. Goodwin K. & Nelson C.M. (2018) Myoepithelial crowd control of cancer. *J. Cell Biol.,* 217: 3319-3321. [**[pdf]**](121_Goodwin_JCB_2018.pdf) |
|  |  | 120. Nelson C.M. (2018) Epithelial packing: Even the best of friends must part. *Curr. Biol.,* 28: R1190-R1211. [**[pdf]**](120_Nelson_CurrBiol_2018.pdf) |
|  |  | 119. Jaslove J.M. & Nelson C.M. (2018) Smooth muscle: a stiff sculptor of epithelial shapes. *Phil. Trans. R. Soc. B.,* 373: 20170318. [**[pdf]**](119_Jaslove_PhilTrans_2018.pdf) |
|  |  | 118. Anlas A.A. & Nelson C.M. (2018) Tissue mechanics regulates form, function, and dysfunction. *Curr. Opin. Cell Biol.,* 54: 98-105. [**[pdf]**](118_Anlas_COCB_2018.pdf) |
|  |  | 117. Kourouklis A.P. & Nelson C.M. (2018) Modeling branching morphogenesis using materials with programmable mechanical instabilities. *Curr. Opin. Biomed. Eng.,* 6: 66-73. [**[pdf]**](117_Kourouklis_COBME_2018.pdf) |
|  |  | 116. Palmer M.A. & Nelson C.M. (2018) Epithelial tube fusion as a mechanism for the formation of complex lumen-containing organs. *Trends Dev. Biol.,* 10: 57-69. [**[pdf]**](116_Palmer_Trends_2018.pdf) |
|  |  | 115. Han S., Pang M.F., & Nelson C.M. (2018) Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1. *J. Cell Sci.,* 131, jcs210476. [**[pdf]**](115_Han_JCS_2018.pdf) [**[first person]**](115_Han_JCS_first_person.pdf) |
|  |  | 114. Simi A.K., Anlas A.A., Stallings-Mann M., Zhang S., Hsia T., Cichon M., Radisky D.C., & Nelson C.M. (2018) A soft microenvironment protects from failure of midbody abscission and multinucleation downstream of the EMT-promoting transcription factor Snail. *Cancer Res.,* 78: 2277-2289. [**[pdf]**](114_Simi_CancerRes_2018.pdf) **[[cover]](http://cancerres.aacrjournals.org/content/78/9.cover-expansion)** |
|  |  | 113. Silver B.B. & Nelson C.M. (2018) The bioelectric code: reprogramming cancer and aging from the interface of mechanical and chemical microenvironments. *Frontiers Cell Dev. Biol.*, 6: 21. [**[pdf]**](113_Silver_Frontiers_2018.pdf) |
|  |  | 112. Simi A.K., Pang M.F., & Nelson C.M. (2018) Extracellular matrix exists in a feedback loop that drives tumor progression. In *Biomechanics in Oncology* (eds. Kuhn N., Dong C., & Konstantopoulos K.), in press. |
|  |  | 111. Nelson C.M., Gleghorn J.P., Pang M.F., Jaslove J., Goodwin K., Varner V.D., Miller E., Radisky D.C., & Stone H.A. (2017) Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development. *Development,* in 144: 4328-4335. [**[pdf]**](111_Gleghorn_Development_2017.pdf) |
|  |  | 110. Piotrowski-Daspit A.S., Nerger B.A., Wolf A.E., Sundaresan S., & Nelson C.M. (2017) Dynamics of tissue-induced alignment of fibrous extracellular matrix. *Biophys. J.,* 113: 702-713. [**[pdf]**](110_PiotrowskiDaspit_BiophysJ_2017.pdf) |
|  |  | 109. Siedlik M.J., Manivannan S., Kevrekidis I.G., & Nelson C.M. (2017) Cell division induces and switches coherent angular motion within bounded cellular collectives. *Biophys. J.,* 112: 2419-2427. **[[pdf]](109_Siedlik_BiophysJ_2017.pdf)** |
|  |  | 108. Goodwin K. & Nelson C. M. (2017) Generating tissue topology through remodeling of cell-cell adhesions. *Exp. Cell Res.,* 358: 45-51. [**[pdf]**](108_Goodwin_ECR_2017.pdf) |
|  |  | 107. Nelson C. M. (2017) From static to animated: Measuring mechanical forces in tissues. *J. Cell Biol.,* 216: 29-30. [**[pdf]**](107_Nelson_JCB_2017.pdf) |
|  |  | 106. Nerger B.A., Siedlik M.J., & Nelson C. M. (2017) Microfabricated tissues for investigating traction forces involved in cell migration and morphogenesis. *Cell. Mol. Life Sci.,* 74: 1819-1834. [**[pdf]**](106_Nerger_CMLS_2017.pdf) |
|  |  | 105. Spurlin J.W. & Nelson C. M. (2017) Building branched tissue structures: From single cell guidance to collective construction. *Phil. Trans. R. Soc. B,* 372: 20150527. **[[pdf]](105_Spurlin_PhilTrans_2017.pdf)** |
|  |  | 104. Piotrowski A.S., Simi A.K., Pang M.F., Tien J., & Nelson C.M. (2017) A three-dimensional culture model to study how fluid pressure and flow affect the behavior of aggregates of epithelial cells. In *Mammary Gland Development (Methods in Molecular Biology series)* (eds. Martin F. & Stein T.), 1501: 245-257. **[[pdf]](104_Piotrowski_MiMB_2017.pdf)** |
|  |  | 103. Varner V.D. & Nelson C.M. (2017) Computational models of airway branching morphogenesis. *Semin. Cell Dev. Biol.,* 67: 170-176. [**[pdf]**](103_Varner_SeminCellDevBiol_2017.pdf) |
|  |  | 102. Pang M.F., Siedlik M.J., Han S., Stallings-Mann M., Radisky D.C., & Nelson C.M. (2016) Tissue stiffness and hypoxia modulate the integrin-linked kinase (ILK) to control breast cancer stem-like cells. *Cancer Res.,* 76: 1-11. [**[pdf]**](102_Pang_CancerRes_2016.pdf) |
|  |  | 101. Tzou D., Spurlin J., Pavlovich A.L., Stewart C.R., Gleghorn J.P., & Nelson C.M. (2016) Morphogenesis and morphometric scaling of lung airway development follows phylogeny in chicken, quail, and duck embryos. *EvoDevo,* 7: 12. [**[pdf]**](101_Tzou_EvoDevo_2016.pdf) |
|  |  | 100. Nelson C.M. (2016) Collective migration in tissues. *Mol. Biol. Cell,* 27: 877. [**[pdf]**](100_Nelson_MBoC_2016.pdf) |
|  |  | 99. Piotrowski-Daspit A.S., Tien J., & Nelson C.M. (2016) Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin. *Integr. Biol.,* 8: 319-331. **[[pdf]](99_Piotrowski_IntegrBiol_2016.pdf)** |
|  |  | 98. Navis A. & Nelson C.M. (2016) Pulling together: Tissue-generated forces that drive lumen morphogenesis. *Semin. Cell Dev. Biol.,* 55: 139-147. **[[pdf]](98_Navis_SCDB_2016.pdf)** |
|  |  | 97. Piotrowski-Daspit A.S. & Nelson C.M. (2016) Engineering three-dimensional epithelial tissues embedded within extracellular matrix. *JoVE,* 113: e54283. [**[pdf]**](97_Piotrowski_2016.pdf) |
|  |  | 96. Nelson C.M. (2016) On buckling morphogenesis. *J. Biomech. Eng.,* 138: 021005. **[[pdf]](96_Nelson_JBiomechEng_2016.pdf)** |
|  |  | 95. Siedlik M.J., Varner V.D., & Nelson C.M. (2016) Pushing, pulling, and squeezing our way to understanding mechanotransduction. *Methods,* 94: 4-12. **[[pdf]](95_Siedlik_Methods_2016.pdf)** |
|  |  | 94. Pang M.F., Georgoudaki A.M., Lambu L., Johansson J., Tabor V., Hagikura K., Jin Y., Jansson M., Alexander J.S., Nelson C.M., Jakobsson L., Betsholtz C., Sund M., Karlsson M.C., & Fuxe J. (2015) TGFb1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by activation of CCR7/CCL21-mediated chemotaxis. *Oncogene,* 35: 748-760. **[[pdf]](94_Pang_Oncogene_2016.pdf)** |
|  |  | 93. Kim H.Y., Pang M.F., Varner V.D., Kojima L., Miller E., Radisky D.C., & Nelson C.M. (2015) Localized smooth muscle differentiation is essential for epithelial bifurcation during branching morphogenesis of the mammalian lung. *Dev. Cell,* 34: 719-726. **[[pdf]](93_Kim_DevCell_2015.pdf)** |
|  |  | 92. Varner V.D., Gleghorn J.P., Miller E., Radisky D.C., & Nelson C.M. (2015) Mechanically patterning the embryonic airway epithelium. *Proc. Natl. Acad. Sci. USA*, 112: 9230-9235. [**[pdf]**](92_Varner_PNAS_2015.pdf) [**[supp]**](92_Varner_PNAS_2015supp.pdf) |
|  |  | 91. Gjorevski N., Piotrowski A.S., Varner V.D., & Nelson C.M. (2015) Dynamic tensile forces drive collective migration through three-dimensional extracellular matrices. *Sci. Rep.,* 5: 11458. [**[pdf]**](91_Gjorevski_SciRep_2015.pdf) [**[supp]**](91_Gjorevski_SciRep_2015supp.pdf) |
|  |  | 90. Paluch E.K., Nelson C.M., Biais N., Fabry B., Moeller J., Pruitt B.L., Wollnik C., Krudyasheva G., Rehfeldt F., & Federle W. (2015) Four centuries of cells and mechanical forces. *BMC Biology,* 13: 47. [**[pdf]**](90_Paluch_BMCBiology_2015.pdf) |
|  |  | 89. Cichon M.A., Nelson C.M., & Radisky D.C. (2015) Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion. *Cancer Informatics,* 14: 1-13. [**[pdf]**](89_Radisky_2015.pdf) |
|  |  | 88. Siedlik M.S. & Nelson C.M. (2015) Regulation of tissue morphodynamics: an important role for actomyosin contractility. *Curr. Opin. Genet. Dev.,* 32: 80-85. **[[pdf]](88_Siedlik_COGD_2015.pdf)** |
|  |  | 87. Pang M.F. & Nelson C.M. (2015) Intercellular communication, the tumor microenvironment, and tumor progression. In *Intercellular Communication in Cancer* (ed. Kandouz M.), Springer, 343-362. **[[pdf]](87_Pang_2015.pdf)** |
|  |  | 86. Boghaert E., Radisky D.C., & Nelson C.M. (2014) Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state. *PLOS Comp. Biol.,* 10: e1003997. **[[pdf]](86_Boghaert_PlosCompBiol_2014.pdf)** |
|  |  | 85. Simi A.K., Piotrowski A.S., & Nelson C.M. (2014) Mechanotransduction, metastasis, and genomic instability. In *Genomic Instability and Cancer Metastasis: Mechanisms, Emerging Themes, and Novel Therapeutic Strategies* (eds. Maxwell C. & Roskelley C.), 20: 139-158. **[[pdf]](85_Simi_Metastasis_2014.pdf)** |
|  |  | 84. Varner V.D. & Nelson C.M. (2014) Cellular and physical mechanisms of branching morphogenesis. *Development,* 141: 2750-2759. [**[pdf]**](84_Varner_Development_2014.pdf) |
|  |  | 83. Schwarz U., Nelson C.M., & Silberzan P. (2014) Proteins, cells, and tissues in patterned environments. *Soft Matter,* 10: 2337-2340. [**[pdf]**](83_Schwarz_SoftMatter_2014.pdf) |
|  |  | 82. Jakus Z., Gleghorn J.P., Enis D., Sen A., Chia S., Liu X., Rawnsley D., Yang Y., Hess P., Zou Z., Yang J., Guttentag S., Nelson C.M., & Kahn M.L. (2014) Lymphatic vascular function is required perinatally for lung inflation at birth. *J. Exp. Med.,* 211: 815-826. **[[pdf]](82_Jakus_JExpMed_2014.pdf)** |
|  |  | 81. Siedlik M.J. & Nelson C.M. (2014) Mechanics of tissue morphogenesis. In *Cell and Matrix Mechanics* (eds. Zemel A. & Kaunas R.), CRC Press, 285-308. **[[pdf]](81_Siedlik_Mechanics_2014.pdf)** |
|  |  | 80. Varner V.D. & Nelson C.M. (2014) Toward the directed self-assembly of engineered tissues. *Annu. Rev. Chem. Biomol. Eng.,* 5: 507-526. **[[pdf]](80_Varner_ARCMB_2014.pdf)** |
|  |  | 79. Tien J. & Nelson C.M. (2014) Microstructured extracellular matrices in tissue engineering and development, an update. *Ann. Biomed. Eng.,* 42: 1413-142*3.* [**[pdf]**](79_Tien_ABME_2014.pdf) |
|  |  | 78. Kim H.Y. & Nelson C.M. (2014) Epithelial engineering: from sheets to branched tubes. In *Bio-Inspired Materials for Biomedical Engineering* (eds. Kirscher C.M. & Brennan A.B.), 161-173. |
|  |  | 77. Piotrowski A., Varner V.D., Gjorevski N., & Nelson C.M. (2014) Three-dimensional traction force microscopy of engineered epithelial tissues. In *Tissue Morphogenesis (Methods in Molecular Biology* series*)* (ed. Nelson C.M.) (Springer, New York), 1189: 191-206. **[[pdf]](77_Piotrowski_MiMB_2014.pdf)** |
|  |  | 76. Lee K. & Nelson C.M. (2014) Determining the role of matrix compliance in the differentiation of mammary stem cells. In *Biomimetics and Stem Cells: Methods and Protocols (Methods in Molecular Biology* series*)* (eds. Vunjak-Novakovic G., Turksen K.) (Springer, New York), 1202: 79-94. [**[pdf]**](76_Lee_MiMB_2014.pdf) |
|  |  | 75. Nelson C.M. (2013) Forces in epithelial origami. *Dev. Cell,* 26: 554-556. [**[pdf]**](75_Nelson_DevCell_2013.pdf) |
|  |  | 74. Varner V.D. & Nelson C.M. (2013) Let's push things forward: disruptive technologies and the mechanics of tissue assembly. *Integr. Biol.,* 5: 1162-1173. [**[pdf]**](74_Varner_iBiol_2013.pdf) |
|  |  | 73. Kim H.Y., Varner V.D., & Nelson C.M. (2013) Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. *Development,* 140: 3146-3155. [**[pdf]**](73_Kim_Development_2013.pdf) |
|  |  | 72. Zhu W. & Nelson C.M. (2013) PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. *Dev. Biol.,* 379: 235-245. **[[pdf]](72_Zhu_DevBiol_2013.pdf)** |
|  |  | 71. Radisky D.C. & Nelson C.M. (2013) Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. *Oncotarget,* 4: 498-499. [**[pdf]**](71_Radisky_Oncotarget_2013.pdf) |
|  |  | 70. Gleghorn J.P., Manivannan S., & Nelson C.M. (2013) Quantitative approaches to uncover physical mechanisms of morphogenesis. *Curr. Opin. Biotechnol.,* 24: 954-961. **[[pdf]](70_Gleghorn_COBT_2013.pdf)** |
|  |  | 69. Zhu W. & Nelson C.M. (2013) Adipose and mammary epithelial tissue engineering. *Biomatter,* 3: e24630. **[[pdf]](69_Wenting_Biomatter_2013.pdf)** |
|  |  | 68. Chen Q.K., Lee K., Radisky D.C., & Nelson C.M. (2013) Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. *Differentiation,* 86: 126-132. |
|  |  | 67. Mori H., Lo A.T., Ghajar C.M., Inman J.L., Alcaraz J., Chen C.S., Nelson C.M., Zhang H., Mott J.D., Bascom J.L., Seiki M., & Bissell M.J. (2013) Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1. *Development,* 140: 343-352. **[[pdf]](67_Mori_Development.pdf)[[supp]](67_Mori_Development_2012_supp.pdf)** |
|  |  | 66. Boghaert E., Gleghorn J.P., Lee K., Gjorevski N., Radisky D.C., & Nelson C.M. (2012) Host epithelial geometry regulates breast cancer cell invasiveness. *Proc. Natl. Acad. Sci. USA,* 109: 19362-19367. [**[pdf]**](66_Boghaert_PNAS_2012.pdf)**[[supp]](66_Boghaert_PNAS_2012_supp.pdf)** |
|  |  | 65. Nelson C.M. (2012) Symmetry breaking during morphogenesis in the embryo and in engineered tissues. *AIChE J.,* 58: 3608-3613. **[[pdf]](65_Nelson_AIChEJ_2012.pdf)[[cover]](65_Nelson_AIChEJ_2012_cover.jpg)** |
|  |  | 64. Tien J., Truslow J.G., & Nelson C.M. (2012) Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells. *PLOS ONE,* 7: e45191. **[[pdf]](64_Tien_PlosOne_2012.pdf)** |
|  |  | 63. Lee K., Chen Q.K., Lui C., Cichon M.A., Radisky D.C., & Nelson C.M. (2012) Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. *Mol. Biol. Cell,* 23: 4097-4108. **[[pdf]](63_Lee_MBoC_2012.pdf)[[supp]](63_Lee_MBoC_2012supp.pdf)[[cover]](63_Lee_MBoC_2012cover.tif)** |
|  |  | 62. Manivannan S. & Nelson C.M. (2012) Dynamics of branched tissue assembly. *Stem Cell Res. Ther.,* 3: 42. **[[pdf]](62_Manivannan_StemCell_2012.pdf)** |
|  |  | 61. Gjorevski N. & Nelson C.M. (2012) Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. *Biophys. J.,* 103: 152-162. [**[pdf]**](61_Gjorevski_BiophysJ_2012.pdf)[**[supp]**](61_Gjorevski_BiophysJ_2012supp.pdf) |
|  |  | 60. Zhu W. & Nelson C.M. (2012) PI3K signaling in the regulation of branching morphogenesis. *BioSystems,* 109: 403-411. [**[pdf]**](60_Zhu_BioSystems_2012.pdf) |
|  |  | 59. Gleghorn J.P., Kwak J., Pavlovich A.L., & Nelson C.M. (2012) Inhibitory morphogens and monopodial branching of the embryonic chicken lung. *Dev. Dyn.,* 241: 852-862. **[[pdf]](59_Gleghorn_DevDyn_2012.pdf)** |
|  |  | 58. Kim H.Y. & Nelson C.M. (2012) Extracellular matrix and cytoskeletal dynamics during branching morphogenesis. *Organogenesis,* 8: 56-64. [**[pdf]**](58_Kim_Organogenesis_2012.pdf) |
|  |  | 57. Chung J.W., Lee K., Neikirk C., Nelson C.M., & Priestley R.D. (2012) Photo-responsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier. *Small,* 8: 1693-1700. **[[pdf]](57_Chung_Small_2012.pdf)** |
|  |  | 56. Nelson C.M. & Gleghorn J.P. (2012) Sculpting organs: Mechanical regulation of tissue development. *Annu. Rev. Biomed. Eng.,* 14: 129-154. **[[pdf]](56_Gleghorn_ARBME_2012.pdf)** |
|  |  | 55. Nelson C.M. (2012) Bioengineering and mechanobiology: pushing (and pulling) the limits of cellular mechanics. *Mol. Biol. Cell,* 23: 969. **[[pdf]](55_Nelson_MBoC_2012.pdf)** |
|  |  | 54. Lui C., Lee K., & Nelson C.M. (2012) Matrix compliance and RhoA direct the differentiation of mammary progenitor cells. *Biomech. Model. Mechanobiol.,* 11: 1241-1249. **[[pdf]](54_Lui_BMMB_2012.pdf)** |
|  |  | 53. Gjorevski N., Boghaert E., & Nelson C.M. (2012) Regulation of epithelial-mesenchymal transition by transmission of mechanical stress through epithelial tissues. *Cancer Microenvironment,* 5: 29-38. [**[pdf]**](53_Gjorevski_CancerMicro_2012.pdf) |
|  |  | 52. Gleghorn J.P. & Nelson C.M. (2012) Nanopatterned surfaces for exploring and regulating cell behavior. *Encyclopedia Nanotech.,* (ed. Bhushan B.) (Springer, New York), pp. 1670-1678. [**[pdf]**](52_Gleghorn_EncyclopediaNanotech.pdf) |
|  |  | 51. Manivannan S., Gleghorn J.P., & Nelson C.M. (2012) Engineered tissues to quantify collective cell migration during morphogenesis. In *Kidney Development: Methods and Protocols (Methods in Molecular Biology* vol. 886*)* (ed. Michos O.) (Springer, New York), pp. 173-182. [**[pdf]**](51_Manivannan_MiMB_2012.pdf) |
|  |  | 50. Cung K., Slater R.L., Cui Y., Manivannan S., Jones S.E., Ahmad H., Nelson C.M., Naik R.R., & McAlpine M.C. (2012) Rapid, multiplexed microfluidic phage display. *Lab Chip,* 12: 562-565. **[[pdf]](50_Cung_LabChip_2012.pdf)** |
|  |  | 49. Lee K. & Nelson C.M. (2012) New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. *Int. Rev. Cell Mol. Biol.,* 294: 169-219. **[[pdf]](49_Lee_IRCMB_2012.pdf)** |
|  |  | 48. Gjorevski N. & Nelson C.M. (2011) Integrated morphodynamic signalling of the mammary gland. *Nat. Rev. Mol. Cell Biol.,* 12: 581-593. **[[pdf]](48_Gjorevski_NRMCB_2011.pdf)** |
|  |  | 47. Lee K., Gjorevski N., Boghaert E., Radisky D.C., & Nelson C.M. (2011) Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. *EMBO J.,* 30: 2662-2674. **[[pdf]](47_Lee_EMBOJ_2011.pdf)[[supp]](47_Lee_EMBOJ_supp.pdf)** |
|  |  | 46. Pavlovich A.L., Boghaert E., & Nelson C.M. (2011) Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFbeta in culture. *Exp. Cell Res.,* 317: 1872-1884. **[[pdf]](46_Pavlovich_ECR_2011.pdf)** |
|  |  | 45. Gomez E.W. & Nelson C.M. (2011) Lithographically-defined two- and three-dimensional tissue microarrays. In *Biological Microarrays (Methods in Molecular Biology, vol. 671)* pp. 107-116 (eds. Khademhosseini A., Suh K.-Y., & Zourob M.) (Springer, New York). **[[pdf]](45_Gomez_MethodsMolBiol_2011.pdf)** |
|  |  | 44. Raghavan S., Shen C.J., Desai R.A., Sniadecki N.J., Nelson C.M., & Chen C.S. (2010) Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. *J. Cell Sci.,* 123: 2877-2883. [**[pdf]**](44_Raghavan_JCS_2010.pdf) |
|  |  | 43. Gjorevski N. & Nelson C.M. (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. *Integr. Biol.,* 2: 424-434. **[[pdf]](43_Gjorevski_iBiol_2010.pdf)****[[supp]](43_Gjorevski_iBiol_2010supp.pdf)** |
|  |  | 42. Pavlovich A.L., Manivannan S., & Nelson C.M. (2010) Adipose stroma induces branching morphogenesis of engineered epithelial tubules. *Tissue Eng. Part A,* 16: 3719-3726. **[[pdf]](42_Pavlovich_TissueEng_2010.pdf)** |
|  |  | 41. Boghaert E. & Nelson C.M. (2010) Tumor microenvironment and host/stroma interactions: Guidelines for physical modeling. in *Biophysical Modeling of Cancer in Silico* (ed. Cristini V.), in press (Springer, New York). |
|  |  | 40. Gjorevski N. & Nelson C.M. (2010) The mechanics of development: models and methods for tissue morphogenesis. *Birth Defects Res. C Embryo Today,* 90: 193-202. **[[pdf]](40_Gjorevski_EmbryoToday_2010.pdf)** |
|  |  | 39. Liu Z., Tan J.L., Cohen D.M., Yang M.T., Sniadecki N.J., Ruiz S.A., Nelson C.M., & Chen C.S. (2010) Mechanical tugging forces regulate the size of cell-cell junctions. *Proc. Natl. Acad. Sci. USA,* 107: 9944-9949. **[[pdf]](39_Liu_PNAS_2010.pdf)[[supp]](39_Liu_PNAS_2010supp.pdf)** |
|  |  | 38. Raghavan S., Nelson C.M., Baranski J.D., Lim E., & Chen C.S. (2010) Geometrically controlled endothelial tubulogenesis in micropatterned gels. *Tissue Eng. Part A,* 16: 2255-2263. **[[pdf]](38_Raghavan_TissueEng_2010.pdf)** |
|  |  | 37. Gjorevski N. & Nelson C.M. (2010) Branch formation during organ development. *Wiley Interdiscip. Rev. Systems Biol. Med.,* 2: 734-741. **[[pdf]](37_Gjorevski_WIREs_2010.pdf)** |
|  |  | 36. Gomez E.W., Chen Q.K., Gjorevski N., & Nelson C.M. (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. *J. Cell. Biochem.,* 110: 44-51. **[[pdf]](36_Gomez_JCB_2010.pdf)[[supp]](36_Gomez_JCB_2010_supp.pdf)****[[cover]](36_Gomez_JCB_cover.pdf)** |
|  |  | 35. Mori H., Gjorevski N., Inman J.L., Bissell M.J., & Nelson C.M. (2009) Self-organization of engineered epithelial tubules by differential cellular motility. *Proc. Natl. Acad. Sci. USA,* 106: 14890-14895. **[[pdf]](35_Mori_PNAS_2009.pdf)****[[supp]](35_Mori_PNAS_supp.pdf)** |
|  |  | 34. Gjorevski N. & Nelson C.M. (2009) Bidirectional extracellular matrix signaling during tissue morphogenesis. *Cytokine Growth Factor Rev.,* 20: 459-465. **[[pdf]](34_Gjorevski_CGFR_2009.pdf)** |
|  |  | 33. Chen C.S., Nelson C.M., Khauv D., Bennett S., Radisky E.S., Hirai Y., Bissell M.J., & Radisky D.C. (2009) Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. *J. Biol. Chem.,* 284: 6877-6884. **[[pdf]](33_Chen_JBC.pdf)****[[cover]](33_Chen_JBC_cover.jpg)** |
|  |  | 32. Nelson C.M. (2009) Geometric control of tissue morphogenesis. *Biochim. Biophys. Acta,* 1793: 903-910. **[[pdf]](32_Nelson_BBA_2009.pdf)** |
|  |  | 31. LaBarge M.A., Nelson C.M., Villadsen R., Fridriksdottir A., Ruth J.R., Stampfer M.R., Petersen O.W., & Bissell M.J. (2009) Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. *Integr. Biol.,* 1: 70-79. **[[pdf]](31_LaBarge_iBiology_2009.pdf)[[cover]](31_LaBarge_2009_cover.jpg)** |
|  |  | 30. Xu R., Nelson C.M., Muschler J.L., Vonderhaar B.K., & Bissell M.J. (2009) Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. *J. Cell Biol.,* 184: 57-66. **[[pdf]](30_Xu_JCB_2009.pdf)** |
|  |  | 29. Alcaraz J., Xu R., Mori H., Nelson C.M., Mroue R., Spencer V.A., Brownfield D., Radisky D.C., Bustamante C., & Bissell M.J. (2008) Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. *EMBO J.,* 27: 2829-2838. **[[pdf]](29_Alcaraz_EmboJ_2008.pdf)** |
|  |  | 28. Gray D.S., Liu W.F., Shen C.J., Bhadriraju K., Nelson C.M., & Chen C.S. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. *Exp. Cell. Res.,* 314: 2846-2854. [**[pdf]**](28_Gray_ExpCellRes_2008.pdf) |
|  |  | 27. Nelson C.M., Khauv D., Bissell M.J., & Radisky D.C. (2008) Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. *J. Cell. Biochem.,* 105: 25-33. **[[pdf]](27_Nelson_JCellBiochem_2008.pdf)[[cover]](27_Nelson_JCB_cover.gif)** |
|  |  | 26. Nelson C.M., Inman J.L., & Bissell M.J. (2008) Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. *Nat. Protoc.,* 3: 674-678. **[[pdf]](26_Nelson_NatProt_2008.pdf)** |
|  |  | 25. Liu W.F., Nelson C.M., Tan J.L., & Chen C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. *Circ. Res.,* 101: e44-52. **[[pdf]](25_Liu_CircRes_2007.pdf)** |
|  |  | 24. Hirai Y., Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., & Radisky D.C. (2007) The non-classical export of epimorphin and its adhesion to alpha-v-integrin for regulation of epithelial morphogenesis. *J. Cell Sci.,* 120: 2032-2043. **[[pdf]](24_Hirai_JCS_2007.pdf)** |
|  |  | 23. LeBeyec J., Xu R., MoonLee S.Y., Nelson C.M., Rizki A., Alcaraz J., & Bissell M.J. (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. *Exp. Cell Res.,* 313: 3066-3075. **[[pdf]](23_LeBeyec_ECR_2007.pdf)** |
|  |  | 22. Itoh M., Nelson C.M., Myers C.A., & Bissell M.J. (2007) Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. *Cancer Res.,* 67: 4759-4766. **[[pdf]](22_Itoh_CancerRes_2007.pdf)****[[cover]](22_Itoh_CancerRes_2007cover.gif)** |
|  |  | 21. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., & Bissell M.J. (2006) Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. *Science,* 314: 298-300. **[[pdf]](21_Nelson_Science_2006.pdf)****[[supp]](21_Nelson_Science_2006_supp.pdf)** |
|  |  | 20. Nelson C.M. & Tien J. (2006) Microstructured extracellular matrices in tissue engineering and development. *Curr. Opin. Biotech.,* 17: 518-523. [**[pdf]**](20_Nelson_COBT_2006.pdf) |
|  |  | 19. Liu W.F., Nelson C.M., Pirone D.M., & Chen C.S. (2006) E-cadherin engagement stimulates proliferation via Rac1. *J. Cell Biol.,* 173: 431-441.  **[[pdf]](19_Liu_JCB_2006.pdf)**[**[supp]**](19_Liu_JCB_2006_supp.pdf) |
|  |  | 18. Nelson C.M. & Bissell M.J. (2006) Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. *Annu. Rev. Cell Dev. Biol.,* 22: 287-309. [**[pdf]**](18_Nelson_ARCDB_2006.pdf) |
|  |  | 17. Kenny P.A., Nelson C.M., & Bissell M.J. (2006) The ecology of tumors. *The Scientist,* April: 30-37. **[[pdf]](17_Kenny_Scientist_2006.pdf)** |
|  |  | 16. Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., & Bissell M.J. (2006) Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. *Proc. Natl. Acad. Sci. USA,*103: 4134-4139. **[[pdf]](16_Liu_PNAS_2006.pdf)[[supp]](16_Liu_PNAS_2006_supp.pdf)** |
|  |  | 15. Nelson C.M., Liu W.F., & Chen C.S. (2006) Manipulation of cell-cell adhesion using bowtie-shaped microwells. *Adhesion Protein Protocols (Methods in Molecular Biology, Vol. 96),* 1-10. [**[pdf]**](15_Nelson_MiMB_2006.pdf) |
|  |  | 14. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., & Chen C.S. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. *Proc. Natl. Acad. Sci. USA,* 102: 11594-11599. **[[pdf]](14_Nelson_PNAS_2005.pdf)[[supp]](14_Nelson_PNAS_2005_supp.pdf)** |
|  |  | 13. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., & Bissell M.J. (2005) Rac1b and reactive oxygen species mediate MMP3-induced EMT and genomic instability. *Nature,* 436: 123-127. **[[pdf]](13_Radisky_Nature_2005.pdf)** |
|  |  | 12. Nelson C.M, & Bissell M.J. (2005) Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. *Semin. Cancer Biol.,* 15: 342-352. **[[pdf]](12_Nelson_SeminCancerBiol_2005.pdf)** |
|  |  | 11. Alcaraz J., Nelson C.M., & Bissell M.J. (2004) Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. *J. Mammary Gland Biol. Neoplasia,* 9: 361-374. **[[pdf]](11_Alcaraz_JMammaryGlandBiolNeoplasia_2004.pdf)** |
|  |  | 10. Tan J.L., Liu W., Nelson C.M., Raghavan S., & Chen C.S. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. *Tissue Eng.,* 10: 865-872. **[[pdf]](10_Tan_TissueEng_2004.pdf)** |
|  |  | 9. Nelson C.M., Pirone D.M., Tan J.L., & Chen C.S. (2004) Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. *Mol. Biol. Cell,* 15: 2943-2953. **[[pdf]](9_Nelson_MBoC_2004.pdf)[[supp]](9_Nelson_MBoC_2004_supp.pdf)** |
|  |  | 8. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., & Chen C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. *Dev. Cell,* 6: 483-495. **[[pdf]](8_McBeath_DevCell_2004.pdf)** |
|  |  | 7. Nelson C.M. & Chen C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. *J. Cell Sci.,* 116: 3571-3581. **[[pdf]](7_Nelson_JCS_2003.pdf)****[[cover]](7_Nelson_JCS_cover.jpg)** |
|  |  | 6. Nelson C.M. & Chen C.S. (2003) Engineering cell adhesion for biotechnology applications. *Chem. Eng. Tech.,* in press. **[[pdf]](6_Nelson_ChemEngTech_2003.pdf)** |
|  |  | 5. Nelson C.M., Raghavan S., Tan J.L., & Chen C.S. (2003) Degradation of micropatterned surfaces by cell-dependent and -independent processes. *Langmuir,* 19: 1493-1499. **[[pdf]](5_Nelson_Langmuir_2003.pdf)** |
|  |  | 4. Tan J.L., Nelson C.M., Gray D.S., & Chen C.S. (2002) Approaches to organize cells on surfaces. *IEEE Engineering in Medicine and Biology Magazine,*101-103. [**[pdf]**](4_Tan_IEEE_2002.pdf) |
|  |  | 3. Nelson C.M. & Chen C.S. (2002) Cell-cell contact increases cell proliferation via a PI3K-dependent signal. *FEBS Letters,* 514: 238-242. **[[pdf]](3_Nelson_FEBS_2002.pdf)** |
|  |  | 2. Tien J., Nelson C.M., & Chen C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. *Proc. Natl. Acad. Sci. USA,* 99: 1758-1762. **[[pdf]](2_Tien_PNAS_2002.pdf)[[cover]](2_Tien_PNAS_cover.jpg)** |
|  |  | 1. Asthagiri A.R., Nelson C.M., Horwitz A.F., & Lauffenburger D.A. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular-signal regulated kinase 2. *J. Biol. Chem.,* 274: 27119-27127. **[[pdf]](1_Asthagiri_JBC_1999.pdf)** |

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