# Immuno-matrix
**Source**: https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-matrix/
**Parent**: https://sites.manchester.ac.uk/lydia-becker-institute/
[Lydia Becker Institute of Immunology and Inflammation](https://sites.manchester.ac.uk/lydia-becker-institute/) / [Research](https://sites.manchester.ac.uk/lydia-becker-institute/research/) / Immuno-matrix
- [The Lydia Becker Institute of Immunology and Inflammation](https://sites.manchester.ac.uk/lydia-becker-institute/)
- [Research](https://sites.manchester.ac.uk/lydia-becker-institute/research/)
- [Barrier immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/barrier-immunology/)
- [Cancer immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/cancer-immunology/)
- [Cardiovascular immunology and multi-morbidities](https://sites.manchester.ac.uk/lydia-becker-institute/research/cardiovascular-immunology-and-multi-morbidities/)
- [Cellular immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/cellular-immunology/)
- [Eco-immunology and context-specific immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/eco-immunology-and-context-specific-immunology/)
- [Immune tolerance](https://sites.manchester.ac.uk/lydia-becker-institute/research/immune-tolerance/)
- [Immuno-informatics](https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-informatics/)
- [Immuno-matrix](https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-matrix/)
- [Life course immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/life-course-immunology/)
- [Neuro-immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/neuro-immunology/)
- [Pathogens, parasites and commensals](https://sites.manchester.ac.uk/lydia-becker-institute/research/pathogens-parasites-and-commensals/)
- [COVID-19](https://sites.manchester.ac.uk/lydia-becker-institute/research/covid-19/)
- [Study](https://sites.manchester.ac.uk/lydia-becker-institute/study/)
- [Partnerships with impact](https://sites.manchester.ac.uk/lydia-becker-institute/partnerships-with-impact/)
- [Updates](https://sites.manchester.ac.uk/lydia-becker-institute/blog/)
- [About us](https://sites.manchester.ac.uk/lydia-becker-institute/about-us/)
- [People](https://sites.manchester.ac.uk/lydia-becker-institute/about-us/people/)
- [Newsletter](https://sites.manchester.ac.uk/lydia-becker-institute/about-us/newsletter/)
# Immuno-matrix
Research into matrix is a major strength at Manchester and immuno-matrix is a central theme of the University’s Wellcome Centre for Cell Matrix Research.
Matrix surrounds and supports our cells and accounts for one third of our body mass. Dysregulation of matrix is a central process in the pathogenesis of most human chronic diseases, and a critical factor in fibrosis (scarring). The extracellular matrix regulates and is regulated by the innate and adaptive immune system.
We study how matrix modulates the response of cells to immune signals and thus contributes to host protection. Conversely, we study how immune signals regulate matrix stiffness and turnover, which is essential for the restoration of tissue homeostasis after injury or infection.
Our research is delivering new insights into the interconnectivity between matrix and immune function, with major implications for treatment of chronic diseases and understanding host–pathogen interactions.
[Immuno-matrix case study](https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-matrix/immuno-matrix-case-study/)
## People
### Leads
[Professor Judi Allen](https://www.research.manchester.ac.uk/portal/judi.allen.html)
[Professor David Thornton](https://www.research.manchester.ac.uk/portal/dave.thornton.html) (Deputy lead)
### Principal investigators
[Dr Jordi Bella](https://www.research.manchester.ac.uk/portal/jordi.bella.html)
[Dr Brian Bigger](https://www.research.manchester.ac.uk/portal/brian.bigger.html)
[Dr Cyrill Bussy](https://www.research.manchester.ac.uk/portal/cyrill.bussy.html)
[Professor Sheena Cruickshank](https://www.research.manchester.ac.uk/portal/sheena.cruickshank.html)
[Professor Tony Day](https://www.research.manchester.ac.uk/portal/anthony.day.html)
[Dr Douglas Dyer](https://www.research.manchester.ac.uk/portal/douglas.dyer.html)
[Professor Kathryn Else](https://www.research.manchester.ac.uk/portal/kathryn.else.html)
[Dr Katie Finegan](https://www.research.manchester.ac.uk/portal/k.g.finegan.html)
[Professor Richard Grencis](https://www.research.manchester.ac.uk/portal/richard.grencis.html)
[Dr Sarah Herrick](https://www.research.manchester.ac.uk/portal/sarah.herrick.html)
[Professor Tracy Hussell](https://www.research.manchester.ac.uk/portal/tracy.hussell.html)
Dr Claus Jorgensen
[Dr Kimberly Mace](https://www.research.manchester.ac.uk/portal/kimberly.mace.html)
[Dr Caroline Milner](https://www.research.manchester.ac.uk/portal/caroline.milner.html)
[Dr Juan Quintana](https://research.manchester.ac.uk/en/persons/juan-quintana)
[Dr Javier Redondo-Munoz](https://www.ucm.es/microbiologia-1/cell-migration-and-epigenetics) (The University of Madrid)
[Dr Dominik Ruckerl](https://www.research.manchester.ac.uk/portal/dominik.ruckerl.html)
[Professor Angela Simpson](https://www.research.manchester.ac.uk/portal/angela.simpson.html)
[Dr Matthew Sinton](https://research.manchester.ac.uk/en/persons/matthew-sinton)
[Dr Tara Sutherland](https://www.research.manchester.ac.uk/portal/tara.sutherland.html)
[Professor David Thornton](https://www.research.manchester.ac.uk/portal/dave.thornton.html)
[Professor Mark Travis](https://www.research.manchester.ac.uk/portal/mark.travis-2.html)
[Professor Jorgen Vestbo](https://www.research.manchester.ac.uk/portal/jorgen.vestbo.html)
#### Contact Us
[+44 (0)161 306 3771](tel:+441613063771)
#### Find Us
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M13 9NT](http://www.manchester.ac.uk/discover/maps/interactive-map/)
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