# Life course immunology

**Source**: https://sites.manchester.ac.uk/lydia-becker-institute/research/life-course-immunology/
**Parent**: https://sites.manchester.ac.uk/lydia-becker-institute/

[Lydia Becker Institute of Immunology and Inflammation](https://sites.manchester.ac.uk/lydia-becker-institute/) / [Research](https://sites.manchester.ac.uk/lydia-becker-institute/research/) / Life course immunology

- [The Lydia Becker Institute of Immunology and Inflammation](https://sites.manchester.ac.uk/lydia-becker-institute/)
- [Research](https://sites.manchester.ac.uk/lydia-becker-institute/research/)
  - [Barrier immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/barrier-immunology/)
  - [Cancer immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/cancer-immunology/)
  - [Cardiovascular immunology and multi-morbidities](https://sites.manchester.ac.uk/lydia-becker-institute/research/cardiovascular-immunology-and-multi-morbidities/)
  - [Cellular immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/cellular-immunology/)
  - [Eco-immunology and context-specific immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/eco-immunology-and-context-specific-immunology/)
  - [Immune tolerance](https://sites.manchester.ac.uk/lydia-becker-institute/research/immune-tolerance/)
  - [Immuno-informatics](https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-informatics/)
  - [Immuno-matrix](https://sites.manchester.ac.uk/lydia-becker-institute/research/immuno-matrix/)
  - [Life course immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/life-course-immunology/)
  - [Neuro-immunology](https://sites.manchester.ac.uk/lydia-becker-institute/research/neuro-immunology/)
  - [Pathogens, parasites and commensals](https://sites.manchester.ac.uk/lydia-becker-institute/research/pathogens-parasites-and-commensals/)
  - [COVID-19](https://sites.manchester.ac.uk/lydia-becker-institute/research/covid-19/)
- [Study](https://sites.manchester.ac.uk/lydia-becker-institute/study/)
- [Partnerships with impact](https://sites.manchester.ac.uk/lydia-becker-institute/partnerships-with-impact/)
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# Life course immunology

Infectious, allergic, autoimmune and autoinflammatory diseases, as well as some cancers are increasingly been recognised as having an immune basis.

The immune basis of disease is often due to specific underlying genetic mutations. Over 300 distinct genetic causes of immune disorders have now been identified and the list continues to grow rapidly.

Many patients present in childhood and are first seen after admission to children’s hospitals, sometimes to intensive care. Other patients are identified because their brothers, sisters or other close family members have a disease.

Paediatric immunology at Manchester provides not only cutting-edge care for these children with use of biologics, stem cell transplantation and recently the potential for gene therapy, but also the power of modern genomic and cellular diagnostic techniques allowing rapid and precise diagnosis and discovery of novel pathways and genes.

[Life course immunology case study](https://sites.manchester.ac.uk/lydia-becker-institute/research/life-course-immunology/life-course-immunology-case-study/)

## People

### Leads

[Dr Peter Arkwright](https://www.research.manchester.ac.uk/portal/peter.arkwright.html)

[Dr Tracy Briggs](https://www.research.manchester.ac.uk/portal/tracy.briggs.html) (Deputy lead)

### Principal investigators

[Professor John Aplin](https://www.research.manchester.ac.uk/portal/john.aplin.html)

[Dr Brian Bigger](https://www.research.manchester.ac.uk/portal/brian.bigger.html)

[Dr Tracy Briggs](https://www.research.manchester.ac.uk/portal/tracy.briggs.html)

[Professor Daniel Brison](mailto:daniel.brison@manchester.ac.uk)

Dr Paul Brownbill

[Professor Silvia Bulfone-Paus](https://www.research.manchester.ac.uk/portal/silvia.bulfone-paus.html)

[Dr Igor Chernyavsky](https://www.research.manchester.ac.uk/portal/igor.chernyavsky.html)

[Dr Elizabeth Cottrell](mailto:elizabeth.cottrell@manchester.ac.uk)

[Dr Ian Crocker](https://www.research.manchester.ac.uk/portal/ian.crocker.html)

[Dr Michelle Desforges](https://www.research.manchester.ac.uk/portal/michelle.desforges.html)

[Dr Mark Dilworth](https://www.research.manchester.ac.uk/portal/m.r.dilworth.html)

[Professor Kathryn Else](https://www.research.manchester.ac.uk/portal/kathryn.else.html)

[Dr Susan Greenwood](https://www.research.manchester.ac.uk/portal/en/researchers/susan-greenwood(4d731a49-4768-44e1-a09a-298b3e372297).html)

[Dr Lynda Harris](https://www.research.manchester.ac.uk/portal/lynda.k.harris.html)

[Dr Reinmar Hager](https://research.manchester.ac.uk/en/persons/reinmar.hager)

[Professor Alexander Heazell](https://www.research.manchester.ac.uk/portal/alexander.heazell.html)

[Dr Lucy Higgins](https://www.research.manchester.ac.uk/portal/lucy.higgins.html)

Dr Stephen Hughes

[Dr Emma Ingram](https://www.research.manchester.ac.uk/portal/emma.ingram.html)

[Professor Edward Johnstone](https://www.research.manchester.ac.uk/portal/edward.johnstone.html)

[Dr Janet McDonagh](https://www.research.manchester.ac.uk/portal/janet.mcdonagh.html)

[Dr Madhvi Menon](https://www.research.manchester.ac.uk/portal/madhvi.menon.html)

[Professor Clare Mills](https://www.research.manchester.ac.uk/portal/clare.mills.html)

[Dr Clare Murray](https://www.research.manchester.ac.uk/portal/clare.murray.html)

[Dr Jenny Myers](https://www.research.manchester.ac.uk/portal/jenny.myers.html)

[Professor William Newman](https://www.research.manchester.ac.uk/portal/william.newman.html)

[Professor Nikolaos Papadopoulos](https://www.research.manchester.ac.uk/portal/nikolaos.papadopoulos.html)

[Dr Joanne Pennock](https://www.research.manchester.ac.uk/portal/joanne.l.pennock.html)

[Dr Peter Ruane](mailto:peter.ruane@manchester.ac.uk)

Dr Vibha Sharma

[Professor Angela Simpson](https://www.research.manchester.ac.uk/portal/angela.simpson.html)

[Dr Adam Stevens](https://www.research.manchester.ac.uk/portal/adam.stevens.html)

[Dr Claire Tower](mailto:clare.tower@manchester.ac.uk)

[Professor Melissa Westwood](https://www.research.manchester.ac.uk/portal/en/researchers/melissa-westwood(e0d3ada0-6a2a-4987-bb87-5a07129ccb17).html)

[Dr Melissa Whitworth](https://mft.nhs.uk/saint-marys/consultants/dr-melissa-whitworth/)

[Steph Worton ACL](mailto:stephanie.worton@manchester.ac.uk)

Professor Rob Wynn

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