# 上海交通大学生物医学工程学院

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Multi-mode thermo-immune therapy for cancer

发布时间：2021-12-14 19:14:00

Prof.
Lisa X. Xu's team is the first to propose the concept of thermophysical
immunotherapy for metastatic solid tumor therapy. Through the precise control
of a hybrid thermal process involving rapid LN2 cooling, followed by
rapid radiofrequency heating, sufficient thermal and shear stress are generated
to completely disintegrate the tumor cells and the newly formed tumor vessels.
The sub-lethal temperatures are used to permit the maximal release of viable
tumor antigens and molecular damage factors. The immunogenic
death of tumor cells stimulated the response of antigen presenting cells,
reversed tumor immunosuppressive microenvironment, and activated the CD4+ T cell-dominant neoantigen-specific immune response. The induced antitumor
immune response can inhibit the recurrence and metastasis of solid tumors. The
device for multi-mode thermal therapy is currently undergoing multi-center
clinical trials.

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**Multi-mode thermal
therapy induced antitumor immune response**

**Multi-mode
thermal-immune therapy for metastatic tumor**

**A patient with liver
tumor receiving multi-mode thermal therapy**

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**Selected Publications:**

1.       
Wang X, Li W, Zhang K, et al. A novel
local tumor progression prediction method for multimode ablation treatment. IEEE Transactions on Biomedical Engineering,
2021.

2.       
Wang S, Cheng M, Peng P, Lou Y, Zhang A,
and Liu P. Iron released after cryo-thermal therapy induced M1 macrophage
polarization, promoting the differentiation of CD4+ T cells into
CTLs. International Journal of
molecular sciences, 2021, 22(13):7010.

3.       
Peng P, Hu H, Liu P, and Xu LX.
Neoantigen-specific CD4+ T-cell response is critical for the therapeutic
efficacy of cryo-thermal therapy. Journal
for ImmunoTherapy of Cancer, 2020, 8(2): e000421.

4.       
He K, Jia S, Lou Y, Liu P, and Xu LX.
Cryo-thermal therapy induces macrophage polarization for durable anti-tumor
immunity. Cell Death & Disease,
2019, 10(3): 216.

5.        
He K, Liu P, and Xu LX. The cryo-thermal
therapy eradicated melanoma in mice by eliciting CD4(+) T-cell-mediated
antitumor memory immune response. Cell
Death & Disease, 2017, 8(3): e2703.