上海交通大学生物医学工程学院
Source: https://bme.sjtu.edu.cn/Web/Show/2598 Parent: https://bme.sjtu.edu.cn/Web/Picture/346
科学研究
工程中心 重点实验室 校内平台 产学研联合基地 - 磁共振国家工程研究中心
中心概况 中心动态 平台建设 人才培养 仪器设备 - 临床转化中心 - 公共平台
纳米、分子及再生医学 平台 生物医疗仪器 影像、计算机系统生物学系统
Micro-instruments and manipulation
发布时间：2021-12-14 19:05:00
Recent advances in soft materials, new fabrication schemes, and continuum actuation have supported the development of new micro-instruments and robotics. A fabrication scheme for miniaturized smart soft composite actuator has been proposed, which can generate a 390 μN force and achieve a large bending angle of 80°. Applications to grasping small and delicate objects with single and two finger devices have been demonstrated. The range of micro-devices developed also includes the design of a microscale piston, with a maximum dimension of 150 micrometers, fabricated with two-photon lithography onto the tip of 140 micrometer-diameter capillaries, as well as sub-millimeter microfluidic chips to deliver nanoliter droplets for liquid biopsy and in vivo drug screening. Related to these work, a microrobotic platform has been developed for the functionalization of fibers of diameters from 140 to 830 micrometers, with a patterning precision of 5 micrometers and an orientation error below 0.4°. This level of transfer precision would allow for the fabrication of micro-sensor arrays and electronic circuits to perform in situ biomarker detection and robot assisted intervention.
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Floating magnetic microrobots for fiber functionalization
Principle of operation of the proposed micropiston
Micropiston-based compliant gripper
Schematic of the delivery sampling probe
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Selected Publications：
1. Barbot A, Tan H, Power M, et al. Floating magnetic microrobots for fiber functionalization. Science Robotics, 2019, 4(34): eaax8336.
2. Barbot A, Power M, F Seichepine, et al. Liquid seal for compact micropiston actuation at the capillary tip. Science Advances, 2020, 6(22): eaba5660.
3. Barbot A, Wales D, Yeatman E, and Yang G-Z. Microfluidics at fiber tip for nanoliter delivery and sampling. Advanced Science, 2021, 8(10): 2004643.
4. Lee H T, Seichepine F, and Yang G-Z. Microtentacle actuators based on shape memory alloy smart soft composite. Advanced Functional Materials, 2020, 30(34): 2002510.
5. Gao A, Liu N, Zhang H, Wu Z, and Yang G-Z. Spiral FBG sensors-based contact detection for confocal laser endomicroscopy. Biosensors and Bioelectronics, 2020, 170: 112653.