# 上海交通大学生物医学工程学院
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科学研究
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- [磁共振国家工程研究中心](https://bme.sjtu.edu.cn/Web/Content/359)
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[平台建设](https://bme.sjtu.edu.cn/Web/Picture/373)
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- [临床转化中心](https://bme.sjtu.edu.cn/Web/ResearchBase/241)
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[纳米、分子及再生医学](https://bme.sjtu.edu.cn/Web/Picture/259)
[平台](https://bme.sjtu.edu.cn/Web/Picture/260)
[生物医疗仪器](https://bme.sjtu.edu.cn/Web/Picture/261)
[影像、计算机系统生物学系统](https://bme.sjtu.edu.cn/Web/Picture/262)
- [生物医疗仪器](https://bme.sjtu.edu.cn/Web/Picture/346)
- [纳米、分子及再生医学](https://bme.sjtu.edu.cn/Web/Picture/347)
- [影像、计算及系统生物医学](https://bme.sjtu.edu.cn/Web/Picture/348)
Management of cardiovascular and cerebrovascular diseases
发布时间：2021-12-14 19:22:00
Accurate diagnosis, timely therapeutic
intervention, and effective therapy are unmet clinical needs for both
cardiovascular and cerebrovascular diseases.Angiography is thus far the most widely
used method to guide percutaneous coronary intervention (PCI) in patients with
coronary artery disease. A novel angiography-based approach to estimate the
fractional flow reserve FFR, named quantitative flow ratio (QFR), has been
proposed and applied in the FAVOR III China Project. The lesion selection for
PCI using QFR guidance improved clinical outcomes at 1 year by reducing
procedural complications and improving long-term results.For treating stroke patients, therapeutic strategies based on
transplantation of stem cells hold great promise. Integrated stem cells and
biomaterials have been used to evaluate the prognosis of patients after stroke
as well as the mechanism of brain tissue function repair after stroke in animal
models. Our teams have also developed an MRI/SPECT/fluorescent tri-modal probe that
holds the potential for long-term tracking of MSCs in the treatment of ischemic
brain.Forperioperative
stroke, the effect of low-intensity, pTUS has been
evaluated, providing novel neuromodulation methods and equipment for monitoring
and regulating brain function and treatment of brain disorders.
\
**QRF-guided strategy
of lesion selection improved clinical outcome.**
**IC and IV injections of MSCs improved functional recovery of brain.**
**Transcranial
ultrasound stimulation alleviated ischemic lesion.**
**\**
**Selected Publications****：**
1. Xu B, Tu S,
Song L, et al. Angiographic quantitative flow ratio-guided coronary
intervention (FAVOR III China): a multicentre, randomised, sham-controlled
trial. The Lancet, 2021.
2. Tu S, Westra J, Adjedj J, et al. Fractional flow
reserve in clinical practice: from wire-based invasive measurement to
image-based computation. European Heart Journal, 2020, 41(34): 3271-3279.
3. Tang Y, Zhang C, Wang J, et al.
MRI/SPECT/Fluorescent tri-modal probe for evaluating the homing and therapeutic
efficacy of transplanted mesenchymal stem cells in a rat ischemic stroke model.
Advanced Functional Materials, 2015, 25: 1024–1034
4. Li H, Sun J, Zhang D, et al. Low-intensity (400
mW/cm2, 500 kHz) pulsed transcranial ultrasound preconditioning may
mitigate focal cerebral ischemia in rats. Brain Stimulation, 2017, 10: 695-702.
5. Ding D, Huang J, Westra J, et al. Immediate
post-procedural functional assessment of percutaneous coronary intervention:
current evidence and future directions. European Heart Journal, 2021, 42: 2695-2707.