# Yonsei Institute for Advanced Study
**Source**: https://ibs.yonsei.ac.kr/default.asp
**Parent**: https://graduate.yonsei.ac.kr/graduate_en/intro/departlist.do
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#### [ABOUT US](#)
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#### [RESEARCH](#)
- [Research Areas](https://ibs.yonsei.ac.kr/research.asp?mid=m02_06 "Research Areas")
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### People Submenu
#### [PEOPLE](#)
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### Education Submenu
#### [EDUCATION](#)
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### News Submenu
#### [NEWS](#)
- [Research News](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06 "Research News")
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### Notice Submenu
#### [NOTICE](#)
- [Event](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01 "Event")
- [Seminar](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02 "Seminar")
- [Career](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_03 "Career")
[[Application] 2026 IBS Conference & Yonsei-IBS Nobel Forum](https://stib.ee/ZicL)
### Event [more](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01)
- [2026년 후기 나노바이오메디컬엔지니어링 대학원 과정 입학설명회 개최](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1202&act=view) Mar 9, 2026
- [SF@Y Season 15!](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1201&act=view) Mar 4, 2026
- [Joint Workshop with Department of Artificial Intelligence at Yonsei University](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1198&act=view) Feb 24, 2026
- [IBS CNM Happy Hour with Christmas & Year-End!](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1179&act=view) Dec 26, 2025
- [Bimonthly Science Festival Season 4 (Dec 16, 2025)](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1178&act=view) Dec 17, 2025
### Seminar [more](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02)
- [[Special Seminar] Prof. Karl Böhringer, Nov/13/2025 "Metasurface Optics for Endoscopy and Hyperspectral Imaging"](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02&idx=1161&act=view) Nov 28, 2025
- [[Special Seminar] Prof. Hyunjoon Kong, Nov/10/2025 "Active Matter Engineering for Biotransport Modulation"](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02&idx=1160&act=view) Nov 28, 2025
- [[Special Seminar] Prof. Oleg Gang, Sep/18/2025 "Programmable Nanoscale Materials"](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02&idx=1159&act=view) Nov 28, 2025
- [[Special Seminar] Prof. Namshik Han, Sep/04/2025 "Revealing the Unseen: AI and Quantum-Inspired Approaches in Novel Target Discovery for High Unmet Needs Through Multi-Omics Integration"](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02&idx=1158&act=view) Sep 5, 2025
- [[Special Seminar] Prof. Ki Bum Lee, Aug/25/2025 "Bio-Inspired Nanomedicine for Precision Control of Cell Fate in Disease Microenvironment"](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_02&idx=1112&act=view) Aug 25, 2025
- [Latest News](# "Latest News")
- [Research News](# "Research News")
- [Newsletter](https://ibs.yonsei.ac.kr/newsletter/ "Newsletter")
[Joint Workshop with Department of Artificial Intelligence at Yonsei University
Feb 24, 2026](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1198&act=view)
[[Max Planck & Nature Day @Yonsei] 2025 MPI–IBS Conference & Nature Session
Nov 7, 2025](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1124&act=view)
[2026년 후기 나노바이오메디컬엔지니어링 대학원 과정 입학설명회 개최
Mar 9, 2026](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_01&idx=1202&act=view)
[[Job Opening] 연세대학교 고등과학원 NanoBME전공 전임교원 초빙 인력풀 연장 모집
Sep 11, 2025](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_03&idx=1113&act=view)
[[Job Opening] Max Planck-Yonsei IBS Center (MPYIC) Fellow 모집
Jul 28, 2025](https://ibs.yonsei.ac.kr/notice.asp?mid=m07_03&idx=1104&act=view)
["나노 피지컬 AI로봇 개발해 뇌질환 해결" 노벨상 사관학교, 연세대와 손잡은 이유
Jul 28, 2025](https://ibs.yonsei.ac.kr/news.asp?mid=m06_07&idx=1110&act=view)
[[Research] 식욕·감정도 제어…세계 최초 자기장으로 뇌 회로 자유자재 조절
Jul 26, 2024](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=1035&act=view)
[[Research] '뇌 질환자 부작용 줄인' 뇌-컴퓨터 인터페이스 기술 나왔다
Mar 12, 2024](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=983&act=view)
[[Research] 나노의학연구단, 나노-자기유전학 기술 적용한 파킨슨병 치료법 개발
Feb 2, 2024](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=958&act=view)
[[Research] 치료제 없는 인체 조직 섬유화증, 정밀 진단법 찾았다
Oct 20, 2023](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=921&act=view)
[[Research] 나노기술로 암·알츠하이머 유발 단백질 형성 원리 찾았다
Jan 10, 2023](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=835&act=view)
[[Research] 나노 물질로 바이러스 신속·정확 검출, 고등과학원 다양한 성과에 유엔도 주목
Apr 21, 2022](https://ibs.yonsei.ac.kr/news.asp?mid=m06_06&idx=742&act=view)
### Recent Major Publications
[[Nanobio Interface] Magnetically Guided Flexible Bioelectronic Probe for Single-Cell Recordings in Multi-Scale Biosystems\
Keyword : Magnetic actuation, Soft bioelectronics, Neural interfacing, Organoid electrophysiology
Adv. Mater., Oct 21, 2025](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1200&act=view)
[[Evolutionary Nanomaterials] Molecular Drillers for 2 nm Resolution Nanochannel Perforation of 2D Nanoplates\
Keyword : Nanochannel engineering; 2D nanoplates perforation
J. Am. Chem. Soc., Jan 6, 2025](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1083&act=view)
[[Evolutionary Nanomaterials] Anomalous In-Plane Electrical Anisotropy in Elemental Metal Nanosheets\
Keyword : Electrical anisotropy, Elemental metal nanosheets, Charge transport physics
Nat. Synth., Oct 31, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1070&act=view)
[[Precision Nanomedicine] In Vivo Magnetogenetics for Cell-Type-Specific Targeting and Modulation of Brain Circuits\
Keyword : Magnetogenetics; Cell-type-specific neuromodulation, Remote magnetic control
Nat. Nanotechnol., Jul 2, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1027&act=view)
[[Nanobio Interface] In-Vivo Integration of Soft Neural Probes Through High-Resolution Printing of Liquid Electronics on the Cranium\
Keyword : Liquid electronics printing, Soft neural probes, Cranial integration, High-resolution biointerfaces
Nat. Commun., Feb 27, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=994&act=view)
[[Evolutionary Nanomaterials] A Magnetically Powered Nanomachine with a DNA Clutch\
Keyword : DNA clutch, Programmable magnetic nanomachine, Biohybrid nanorobotics
Nat. Nanotechnol., Feb 7, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=965&act=view)
[[Nanobio Interface] Magnetically Guided Flexible Bioelectronic Probe for Single-Cell Recordings in Multi-Scale Biosystems\
Bioelectronic systems enable label-free monitoring and modulation of cellular activity, providing essential tools for neuroscience and biomedical applications. Nevertheless, many current interfaces are structurally static and lack active positioning capabilities, limiting their adaptability in spatially complex environments. Here, Mag-N-Probe (Magnetically guided Neural-interfacing Probe), a flexible and magnetically actuated bioelectronic system is introduced that enables remote, real-time motion control with sub-micrometer precision and centimeter-scale navigation. The system incorporates ferromagnetic nanoparticles within a pliable mesh framework and utilizes both torque- and gradient force-driven actuation for controlled navigation in confined spaces. This capability permits the repeated targeting of individual neurons for compartment-specific electrophysiological recordings and conformal integration with brain organoids for reliable, multi-channel signal acquisition. By combining magnetic actuation with flexible bioelectronics, Mag-N-Probe provides a versatile and scalable solution for adaptive neural interfacing, applicable to both single-cell studies and 3D tissue environments, thus supporting a wide range of in vitro studies and promising prospects for minimally invasive in vivo applications.
Oct 21, 2025](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1200&act=view)
[[Evolutionary Nanomaterials] Molecular Drillers for 2 nm Resolution Nanochannel Perforation of 2D Nanoplates\
Perpendicular nanochannel creation of two-dimensional (2D) nanostructures requires highly controlled anisotropic drilling processes of the entire structure via void formation. However, chemical approaches for the creation of porosity and defects of 2D nanostructures have been challenging due to the strong basal plane chemical stability and the use of harsh reactants, tending to give randomly corroded 2D structures. In this study, we introduce Lewis acid–base conjugates (LABCs) as molecular drillers with attenuated chemical reactivity which results in the well-defined perpendicular nanochannel formation of 2D TiS2 nanoplates. With the treatment of LABCs, tris(trimethylsilyl)pnictogens (TMS3P or TMS3As), high resolution perforation of TiS2 nanoplates was achieved while maintaining their initial shape and structures. Such perforated TiS2 nanoplates are tunable in their channel diameter between 4 and 10 nm with 2 nm resolution. With their increased surface area and enhanced adsorption of Li2Sx, perforated TiS2 nanoplates served as a diffusion barrier of lithium–sulfur (Li–S) cells, leading to a 2.5-fold improvement in cell performance compared to pristine TiS2 nanoplates. Our molecular design concept for attenuated reactivity of LABCs is simple and could serve as a new approach for chemical drilling processes of 2D metal chalcogenides.
Jan 6, 2025](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1083&act=view)
[[Evolutionary Nanomaterials] Anomalous In-Plane Electrical Anisotropy in Elemental Metal Nanosheets\
Two-dimensional (2D) elemental metals, often overlooked owing to their lack of switching or dielectric properties, have the potential to exhibit unique properties unachievable by their bulk counterparts if their microstructure can be controlled. Here we propose an electrodeposition method that utilizes a confined 2D template to prepare elemental metal nanosheets with an aligned grain orientation, resulting in an exceptionally high in-plane electrical anisotropy of >103. Heterogeneous nucleation is initiated and the directed growth of the metal at the cathode is controlled within a channel whose size is smaller than the critical size of the nuclei. This leads to the formation of anisotropic microstructures, and consequently, the nanosheets exhibit anisotropic electrical properties. Unlike conventional field-effect transistors, devices employing a channel with two orthogonally separated conduction paths yield an exceptional on–off switching ratio exceeding 104. Our approach offers a promising route to produce various 2D elemental metals with properties different from those observed in their bulk counterparts and highlights the potential of anisotropic metallic nanosheets as switching elements.
Oct 31, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1070&act=view)
[[Precision Nanomedicine] In Vivo Magnetogenetics for Cell-Type-Specific Targeting and Modulation of Brain Circuits\
Neuromodulation technologies are crucial for investigating neuronal connectivity and brain function. Magnetic neuromodulation offers wireless and remote deep brain stimulations that are lacking in optogenetic- and wired-electrode-based tools. However, due to the limited understanding of working principles and poorly designed magnetic operating systems, earlier magnetic approaches have yet to be utilized. Furthermore, despite its importance in neuroscience research, cell-type-specific magnetic neuromodulation has remained elusive. Here we present a nanomaterials-based magnetogenetic toolbox, in conjunction with Cre-loxP technology, to selectively activate genetically encoded Piezo1 ion channels in targeted neuronal populations via torque generated by the nanomagnetic actuators in vitro and in vivo. We demonstrate this cell-type-targeting magnetic approach for remote and spatiotemporal precise control of deep brain neural activity in multiple behavioural models, such as bidirectional feeding control, long-term neuromodulation for weight control in obese mice and wireless modulation of social behaviours in multiple mice in the same physical space. Our study demonstrates the potential of cell-type-specific magnetogenetics as an effective and reliable research tool for life sciences, especially in wireless, long-term and freely behaving animals.
Jul 2, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=1027&act=view)
[[Nanobio Interface] In-Vivo Integration of Soft Neural Probes Through High-Resolution Printing of Liquid Electronics on the Cranium\
Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of the device to biological systems and restrict the free behavior of a subject. We report a soft, conformable neural interface system that can monitor the single-unit activities of neurons with long-term stability. The system implements soft neural probes in the brain, and their subsidiary electronics which are directly printed on the cranial surface. The high-resolution printing of liquid metals forms soft neural probes with a cellular-scale diameter and adaptable lengths. Also, the printing of liquid metal-based circuits and interconnections along the curvature of the cranium enables the conformal integration of electronics to the body, and the cranial circuit delivers neural signals to a smartphone wirelessly. In the in-vivo studies using mice, the system demonstrates long-term recording (33 weeks) of neural activities in arbitrary brain regions. In T-maze behavioral tests, the system shows the behavior-induced activation of neurons in multiple brain regions.
Feb 27, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=994&act=view)
[[Evolutionary Nanomaterials] A Magnetically Powered Nanomachine with a DNA Clutch\
Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dynein, myosin or bacterial flagellar motors, allows for temporary disengagement of the moving parts from the running engine. However, such sophistication is still challenging to achieve in artificial nanomachines. Here we present a spherical rotary nanomotor with a reversible clutch system based on precise molecular recognition of built-in DNA strands. The clutch couples and decouples the engine from the machine"s rotor in response to encoded inputs such as DNA or RNA. The nanomotor comprises a porous nanocage as a spherical rotor to confine the magnetic engine particle within the nanospace (∼0.004 μm3) of the cage. Thus, the entropically driven irreversible disintegration of the magnetic engine and the spherical rotor during the disengagement process is eliminated, and an exchange of microenvironmental inputs is possible through the nanopores. Our motor is only 200 nm in size and the clutch-mediated force transmission powered by an embedded ferromagnetic nanocrystal is high enough (∼15.5 pN at 50 mT) for the in vitro mechanical activation of Notch and integrin receptors, demonstrating its potential as nano-bio machinery.
Feb 7, 2024](https://ibs.yonsei.ac.kr/research.asp?mid=m02_03&idx=965&act=view)
### Research Areas
- [Evolutionary Nanomaterials](# "Evolutionary Nanomaterials")
- [Physical AI Nanorobotics](# "Physical AI Nanorobotics")
- [Next-Gen. Non-Invasive BCI](# "Next-Gen. Non-Invasive BCI")
- [Nano-Immunotherapeutics](# "Nano-Immunotherapeutics")
Evolutionary Nanomaterials
This research field focuses on nanoscale designing and engineering of materials to drive advancements in next-generation technologies across electronics, energy, and biomedicine. By exploring unconventional compositions and architectures, researchers aim to develop materials with enhanced or entirely novel functionalities. This innovation-driven approach offers significant potential for addressing complex scientific and biomedical challenges.
[more](https://ibs.yonsei.ac.kr/research.asp?mid=m02_06)
Physical AI Nanorobotics
Our research group explores the frontier of intelligent nano-bio robotics and soft bioelectronics to create transformative biomedical tools. By integrating nanorobots, soft electronics, and magnetically guided systems, we develop next-generation technologies for precise cellular interfacing, diagnostics, and targeted therapies.
[more](https://ibs.yonsei.ac.kr/research.asp?mid=m02_07)
Next-Gen. Non-Invasive BCI
We are developing noninvasive technologies to wirelessly interact with the brain using magnetic nanoparticles and ultrasound. These tools enable precise control and monitoring of specific brain circuits without the need for surgery. Our aim is to transform these innovations into new ways to understand and treat brain disorders.
[more](https://ibs.yonsei.ac.kr/research.asp?mid=m02_08)
Nano-Immunotherapeutics
Nano-immunotherapy harnesses nanoscale engineering to enhance and control immune cell behavior with unprecedented precision. Our work focuses on magnetic and mechanoreceptor-based immune circuits to accelerate and refine T cell responses. These approaches represent a transformative shift in personalized and programmable immunotherapy.
[more](https://ibs.yonsei.ac.kr/research.asp?mid=m02_09)
- [Graduate Program](# "Graduate Program")
- [Undergraduate Program](# "Undergraduate Program")
- M.S. & Ph.D. in Nano\
Biomedical Engineering\
\
The Department of Nano Biomedical Engineering (Nano BME) provides a cutting-edge education and training in nanoscience and nanomedicine.
[MORE INFO](https://ibs.yonsei.ac.kr/program.asp?mid=m05_01 "MORE INFO")
- Research internship
[MORE INFO](https://ibs.yonsei.ac.kr/internship "MORE INFO")- - Science Factory @ Yonsei
[MORE INFO](https://ibs.yonsei.ac.kr/factory "MORE INFO")- - [Biweekly Newsletter](https://ibs.yonsei.ac.kr/newsletter/default.asp?mid=n00&v=7&n=7&act=view&uid=99)
Our\
People
We, the director and faculty of the Department of Nano Biomedical Engineering (Nano BME), strive to promote the highest quality of research that will nurture the current global basic science and generate new opportunities for the future.
[**Jinwoo Cheon (천진우)**
Inorganic Chemistry, Nanoscience & Nanomedicine](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1003)
[**Jae-Hyun Lee (이재현)**
Bio-Electronics](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1004)
[**Minsuk Kwak (곽민석)**
Nanobiotechnology, Cell Engineering, Molecular & Cell Biology](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1165)
[**Peer Fischer**
Micro Nano and Molecular Systems](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1245)
[**Oleg Gang**
Integrated Nanoscale Systems](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1244)
[**Euisik Yoon (윤의식)**
Bio-Electronics](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1067)
[**Mikhail G. Shapiro**
Imaging & Bio-engineering](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1069)
[**Dong Hee Son (손동희)**
Nano-Chemistry and Optics](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1011)
[**Young-Wook Jun (전영욱)**
Nanobiology](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1012)
[**Hakho Lee (이학호)**
Nano-imaging & Biosensor](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1013)
[**Namshik Han (한남식)**
Quantum and AI-driven computational models](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1280)
[**Seung-Woo Cho (조승우)**
Bio-materials Engineering](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1006)
[**Hyongbum Kim (김형범)**
Genomics](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1008)
[**Jang-Ung Park (박장웅)**
Nanoelectronics](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1009)
[**Wooyoung Shim (심우영)**
Nanomaterials](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1010)
[**Jeon-Soo Shin (신전수)**
Immunology](https://ibs.yonsei.ac.kr/people.asp?mid=m04_02&sOpt=A&act=view&uid=1014)
### Global Partnership
[MORE INFORMATION](https://ibs.yonsei.ac.kr/about.asp?mid=m01_05 "MORE INFORMATION")
## Copyright and Address
- Yonsei Institute for Advanced Study
- [PRIVACY POLICY](https://ibs.yonsei.ac.kr/policy.asp?mid=m00_00)
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- TEL +82-2-2123-4743 FAX +82-2-2123-4606
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- Copyright © IBS Center for NanoMedicine,YONSEI UNIV.\
ALL RIGHTS RESERVED.
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