# ResearchInsights into splicing quality control

**Source**: https://www.bio.uni-heidelberg.de/en/newsroom/insights-into-splicing-quality-control
**Parent**: https://www.bio.uni-heidelberg.de/en/news

# Research Insights into splicing quality control

## How cells avoid errors in the production of Messenger RNA

The spliceosome is a complex molecular machine, which ensures that the genetic information of the DNA  - after transcription into a pre-mRNA - is correctly spliced (cut and reassembled) to the mature mRNA required for the production of proteins. The team of Prof. Sinning from the Heidelberg University Biochemistry Center (BZH) succeeded for the first time in depicting a faultily 'blocked' spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell by a molecular short circuit. These mechanistic studies were carried out in collaboration with colleagues at the Australian National University.\

- [Structures of aberrant spliceosome intermediates on their way to disassembly (Nature Structural & Molecular Biology Paper)](https://www.nature.com/articles/s41594-024-01480-7)
- [Sinning Lab](https://bzh.db-engine.de/group/21/sinning)

Splicing quality control: Recognition of an aberrant mRNA stalls the spliceosome by binding of a special G patch protein – helicase pair (Gpl1/Gih35), and induces disassembly by the Ntr1 complex.

[Deutsch](https://www.bio.uni-heidelberg.de/de/node/526)[Contact](https://www.bio.uni-heidelberg.de/en/newsroom/insights-into-splicing-quality-control?overlay=contact)