Using a supramolecular monomer formulation approach to engineer modular, dynamic microgels, and composite macrogels
Source: https://eprints.gla.ac.uk/340179/ Parent: https://eprints.gla.ac.uk/view/project_code/315918.html
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Using a supramolecular monomer formulation approach to engineer modular, dynamic microgels, and composite macrogels
Rovers, Maritza M., Rogkoti, Theodora ORCID: https://orcid.org/0009-0000-5394-9074, Bakker, Bram K., Bakal, Kalpit J., van Genderen, Marcel H.P., Salmeron‐Sanchez, Manuel ORCID: https://orcid.org/0000-0002-8112-2100 and Dankers, Patricia Y.W. (2024) Using a supramolecular monomer formulation approach to engineer modular, dynamic microgels, and composite macrogels. Advanced Materials, 36(30), 2405868. (doi: 10.1002/adma.202405868) (PMID:39463044) (PMCID:PMC11636168)
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Abstract
Microgels show advantages over bulk hydrogels due to convenient control over microgel size and composition, and the ability to use microgels to modularly construct larger hierarchical scaffold hydrogel materials. Here, supramolecular chemistry is used to formulate supramolecular polymer, dynamic microgels solely held together by non-covalent interactions. Four-fold hydrogen bonding ureido-pyrimidinone (UPy) monomers with different functionalities are applied to precisely tune microgel properties in a modular way, via variations in monomer concentration, bifunctional crosslinker ratio, and the incorporation of supramolecular dyes and peptides. Functionalization with a bioactive supramolecular cell-adhesive peptide induced selectivity of cells toward the bioactive microgels over non-active, non-functionalized versions. Importantly, the supramolecular microgels can also be applied as microscale building blocks into supramolecular bulk macrogels with tunable dynamic behavior: a robust and weak macrogel, where the micro- and macrogels are composed of similar molecular building blocks. In a robust macrogel, microgels act as modular micro-building blocks, introducing multi-compartmentalization, while in a weak macrogel, microgels reinforce and enhance mechanical properties. This work demonstrates the potential to modularly engineer higher-length-scale structures using small molecule supramolecular monomers, wherein microgels serve as versatile and modular micro-building units.
| Item Type: | Articles |
| Keywords: | Cell culture, droplet-based microfluidics, hydrogel, microgel, multiscale modularity, supramolecular biomaterial, synthetic extracellular matrix. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Rogkoti, Dora |
| Authors: | Rovers, M. M., Rogkoti, T., Bakker, B. K., Bakal, K. J., van Genderen, M. H.P., Salmeron‐Sanchez, M., and Dankers, P. Y.W. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Advanced Materials |
| Publisher: | Wiley |
| ISSN: | 0935-9648 |
| ISSN (Online): | 1521-4095 |
| Published Online: | 27 October 2024 |
| Copyright Holders: | Copyright © 2024 The Authors |
| First Published: | First published in Advanced Materials 36(30): 2405868 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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Funder and Project Information
Funder and Project Information
Funder and Project Information
Project Code
Award No
Project Name
Principal Investigator
Funder's Name
Funder Ref
Lead Dept
DEVISE - Engineered viscoelasticity in regenerative microenvironments
Manuel Salmeron-Sanchez
101054728
ENG - Biomedical Engineering
Deposit and Record Details
| ID Code: | 340179 |
| Depositing User: | Dr Aniko Szilagyi |
| Datestamp: | 29 Oct 2024 13:50 |
| Last Modified: | 27 May 2025 08:17 |
| Date of first online publication: | 27 October 2024 |
| Date Deposited: | 29 October 2024 |
| Data Availability Statement: | Yes |
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