# Enlighten Theses

**Source**: https://theses.gla.ac.uk/71816/
**Parent**: https://theses.gla.ac.uk/view/subjects/QH345.html

- [Skip to main content](#mainpage)
- [Accessibility information](http://www.gla.ac.uk/about/accessibility/)

Site navigation

- [Study](http://www.gla.ac.uk/study/)
- [Research](http://www.gla.ac.uk/research/)
- [About us](http://www.gla.ac.uk/about/)
- [Student life](http://www.gla.ac.uk/studentlife/)
- [Alumni](http://www.gla.ac.uk/alumni/)
- [Support us](http://www.gla.ac.uk/about/givingtoglasgow/)
- [Contact](http://www.gla.ac.uk/about/contact/)

Site tools

A-Z Lists

- [Subjects A-Z](http://www.gla.ac.uk/subjects/)
- [Staff A-Z](http://www.gla.ac.uk/stafflist/)
- [Academic units A-Z](http://www.gla.ac.uk/academic/)

- [Home](http://www.glasgow.ac.uk)
- [Enlighten](http://www.glasgow.ac.uk/services/enlighten)
- [Theses](http://theses.gla.ac.uk)

# [Enlighten Theses](http://theses.gla.ac.uk)

- [About](http://theses.gla.ac.uk/information.html)
- [Latest Additions](https://theses.gla.ac.uk/cgi/latest)
- [Search](https://theses.gla.ac.uk/cgi/search/advanced)
- [Browse](http://theses.gla.ac.uk/view/)
  - [Browse by
    Year](http://theses.gla.ac.uk/view/year/)
  - [Browse by
    Subject](http://theses.gla.ac.uk/view/subjects/)
  - [Browse by
    College/School](http://theses.gla.ac.uk/view/divisions/)
  - [Browse by
    Author](http://theses.gla.ac.uk/view/creators/)
  - [Browse by
    Funder](http://theses.gla.ac.uk/view/funder/)
- [ORCID](https://www.gla.ac.uk/myglasgow/research/managingyourpublications/publicationsandresearchreputation/identifiers/orcid/)
- [My Thesis](#)
  - [Login (Library staff only)](https://theses.gla.ac.uk/cgi/users/home)

In this section

# Activated protein C resistance in pregnancy

Clark, P. (Peter)
(1999)
*Activated protein C resistance in pregnancy.*
MD thesis, University of Glasgow.

Full text available as:

|  |  |
| --- | --- |
|  | PDF (scanned version of the original print thesis)   [Download (4MB)](https://theses.gla.ac.uk/71816/1/10391472.pdf) |

Printed Thesis Information: <https://eleanor.lib.gla.ac.uk/record=b1824502>

## Abstract

Factor V Leiden (FVL), the principal inherited cause of activated protein C resistance (APCR), has been linked to the failure of pregnancy with an increased risk of venous thrombosis, fetal loss and pre-eclampsia. Both venous thrombosis and pre-eclampsia are associated with inflammation. In particular pre-eclampsia is associated with a monocyte/macrophage infiltration of the placental bed. That APCR, without FVL, (acquired APCR) may be a marker of thrombotic potential out-with pregnancy has been suggested by the association of venous thrombosis with the combined oral contraceptive pill and more recently by the association of venous thrombosis with a low activated protein C sensitivity ratio (the APC:SR). Changes in sensitivity to APC (assessed by the APC:SR) occur in normal pregnancy. The aetiology and significance of this phenomenon has not been fully characterised. In this thesis, the pattern of change in APC:SR in pregnancy was detailed in FVL negative subjects. The relationship of the APC:SR to other coagulation factors and thrombin generation was investigated. The significance of the APC:SR to the mother and the fetus was also examined. To investigate if a link (via thrombin) exists between the APC:SR and the inflammatory response, the inflammatory marker ICAM-1 was examined on the monocyte. The influence of thrombin on the expression of this marker was examined in vitro and the relationship between the APC:SR in pregnancy and ICAM-1 was examined ex vivo. In a prospective study of 1046 pregnancies, the APC:SR at 7-15 weeks gestation showed a significant relationship with blood group and smoking, with higher APC:SRs observed in non-smokers and blood group 0 subjects. No significant relationship of APC:SR with body mass index, waist circumference, age, alcohol consumption, or family history of venous thrombosis or pregnancy-induced hypertension in a first degree relative was observed. In ~75% of pregnancies, a fall in APC:SR with increasing gestation was seen. Those who showed a fall in APC:SR (i.e. an increase in APCR) with increasing gestation had higher absolute APC:SR values at 7-15 weeks gestation than those who did not show a fall. APC:SR values less than the reference range observed in non-pregnant females were seen in 38% of subjects in the third trimester of pregnancy (28 to 40 weeks gestation) in the absence of FVL or elevated ACAs. In subjects without elevated ACAs or FVL, the APC:SR showed a significant negative relationship with factor VIIIc, factor Vc, and a positive relationship with free protein S. The relationship to factor VIIIc is compatible with the association of APCR and inflammatory disorders and with the association of non-blood group 0, higher factor VIIIc levels and venous thrombosis. The relationship with factor Vc is consistent with in vitro evidence that the APC:SR may be affected by factor V. (Abstract shortened by ProQuest.).

|  |  |
| --- | --- |
| Item Type: | Thesis (MD) |
| Qualification Level: | Doctoral |
| Keywords: | Molecular biology, obstetrics, protein C deficiency, thrombosis. |
| Subjects: | [Q Science](https://theses.gla.ac.uk/view/subjects/Q.html) > [QH Natural history](https://theses.gla.ac.uk/view/subjects/QH.html) > [QH345 Biochemistry](https://theses.gla.ac.uk/view/subjects/QH345.html) [R Medicine](https://theses.gla.ac.uk/view/subjects/R.html) > [RG Gynecology and obstetrics](https://theses.gla.ac.uk/view/subjects/RG.html) |
| Colleges/Schools: | [College of Medical Veterinary and Life Sciences](https://theses.gla.ac.uk/view/divisions/20000000/) |
| Supervisor's Name: | Supervisor, not known |
| Date of Award: | 1999 |
| Depositing User: | [Enlighten Team](https://theses.gla.ac.uk/cgi/users/home?screen=User::View&userid=15641) |
| Unique ID: | glathesis:1999-71816 |
| Copyright: | Copyright of this thesis is held by the author. |
| Date Deposited: | 17 May 2019 09:31 |
| Last Modified: | 26 Oct 2022 08:51 |
| Thesis DOI: | [10.5525/gla.thesis.71816](https://doi.org/10.5525/gla.thesis.71816) |
| URI: | <https://theses.gla.ac.uk/id/eprint/71816> |

### Actions (login required)

|  |  |
| --- | --- |
|  | View Item |

### Downloads

Downloads per month over past year

Tools

[Tools](#)

[Tools](#)

RDF+XML
RDF+N-Triples
JSON
RefWorks
Dublin Core
Atom
Simple Metadata
Refer
METS
HTML Citation
ASCII Citation
OpenURL ContextObject
EndNote
OpenURL ContextObject in Span
MODS
MPEG-21 DIDL
EP3 XML
Data Cite XML
Reference Manager
RDF+N3
Multiline CSV

\

[Back to top](#)

## [Library](http://www.gla.ac.uk/services/library/)

- [Contact us](http://www.gla.ac.uk/services/library/contact/)

The University of Glasgow is a registered Scottish charity: Registration Number SC004401