# The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction
**Source**: https://eprints.gla.ac.uk/204480/
**Parent**: https://eprints.gla.ac.uk/view/project_code/303613.html
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# The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction
[Cantini, Marco](https://eprints.gla.ac.uk/view/author/30437.html) [ORCID: https://orcid.org/0000-0003-0326-1508](https://orcid.org/0000-0003-0326-1508), [Donnelly, Hannah](https://eprints.gla.ac.uk/view/author/50686.html) [ORCID: https://orcid.org/0000-0002-5154-9971](https://orcid.org/0000-0002-5154-9971), [Dalby, Matthew J.](https://eprints.gla.ac.uk/view/author/9268.html) [ORCID: https://orcid.org/0000-0002-0528-3359](https://orcid.org/0000-0002-0528-3359) and [Salmeron-Sanchez, Manuel](https://eprints.gla.ac.uk/view/author/30067.html) [ORCID: https://orcid.org/0000-0002-8112-2100](https://orcid.org/0000-0002-8112-2100)
(2020)
The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction.
*[Advanced Healthcare Materials](https://eprints.gla.ac.uk/view/journal_volume/Advanced_Healthcare_Materials.html)*, 9(8),
1901259.
(doi: [10.1002/adhm.201901259](https://doi.org/10.1002/adhm.201901259))
(PMID:[31815372](https://europepmc.org/abstract/MED/31815372))
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| Preview | [Text](https://eprints.gla.ac.uk/204480/1/204480.pdf) 204480.pdf - Published Version Available under License [Creative Commons Attribution](http://creativecommons.org/licenses/by/4.0/). 2MB |
## Abstract
Cell mechanotransduction is an area of intense research focus. Until now, very limited tools have existed to study how cells respond to changes in the extracellular matrix beyond, for example, mechanical deformation studies and twisting cytometry. However, emerging are a range of elastic, viscoelastic and even purely viscous materials that deform and dissipate on cellular length and timescales. This article reviews developments in these materials, typically translating from 2D model surfaces to 3D microenvironments and explores how cells interact with them. Specifically, it focuses on emerging concepts such as the molecular clutch model, how different extracellular matrix proteins engage the clutch under viscoelastic‐stress relaxation conditions, and how mechanotransduction can drive transcriptional control through regulators such as YAP/TAZ.
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| Item Type: | Articles |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | [Salmeron-Sanchez, Professor Manuel](https://eprints.gla.ac.uk/view/author/30067.html) and [Dalby, Professor Matthew](https://eprints.gla.ac.uk/view/author/9268.html) and [Donnelly, Dr Hannah](https://eprints.gla.ac.uk/view/author/50686.html) and [Cantini, Dr Marco](https://eprints.gla.ac.uk/view/author/30437.html) |
| Authors: | [Cantini, M.](https://eprints.gla.ac.uk/view/author/30437.html), [Donnelly, H.](https://eprints.gla.ac.uk/view/author/50686.html), [Dalby, M. J.](https://eprints.gla.ac.uk/view/author/9268.html), and [Salmeron-Sanchez, M.](https://eprints.gla.ac.uk/view/author/30067.html) |
| College/School: | [College of Medical Veterinary and Life Sciences](https://eprints.gla.ac.uk/view/divisions/20000000/) > [School of Molecular Biosciences](https://eprints.gla.ac.uk/view/divisions/25400000/) [College of Science and Engineering](https://eprints.gla.ac.uk/view/divisions/30000000/) > [School of Engineering](https://eprints.gla.ac.uk/view/divisions/30300000/) > [Biomedical Engineering](https://eprints.gla.ac.uk/view/divisions/30303000/) |
| Journal Name: | [Advanced Healthcare Materials](https://eprints.gla.ac.uk/view/journal_volume/Advanced_Healthcare_Materials.html) |
| Publisher: | Wiley |
| ISSN: | 2192-2640 |
| ISSN (Online): | 2192-2659 |
| Published Online: | 09 December 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Advanced Healthcare Materials 9(8):1901259 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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Funder and Project Information
[Funder and Project Information](#)
[Funder and Project Information](#)
Project Code
Award No
Project Name
Principal Investigator
Funder's Name
Funder Ref
Lead Dept
[173192](https://eprints.gla.ac.uk/view/project_code/173192.html)
Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine
Manuel Salmeron-Sanchez
[Engineering and Physical Sciences Research Council (EPSRC)](https://eprints.gla.ac.uk/view/funder/Engineering_and_Physical_Sciences_Research_Council_=28EPSRC=29.html)
EP/P001114/1
ENG - Biomedical Engineering
[303613](https://eprints.gla.ac.uk/view/project_code/303613.html)
Engineered microenvironments to harvest stem cell response to viscosity for cartilage repair
Marco Cantini
[Medical Research Council (MRC)](https://eprints.gla.ac.uk/view/funder/Medical_Research_Council_=28MRC=29.html)
MR/S005412/1
ENG - Biomedical Engineering
[301095](https://eprints.gla.ac.uk/view/project_code/301095.html)
UKRMP2 Acellular/Smart Materials 3D Architecture Hub
Manuel Salmeron-Sanchez
[Medical Research Council (MRC)](https://eprints.gla.ac.uk/view/funder/Medical_Research_Council_=28MRC=29.html)
MMRE\_P75176 (MR/R015651/1
ENG - Biomedical Engineering
Deposit and Record Details
[Deposit and Record Details](#)
[Deposit and Record Details](#)
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| ID Code: | 204480 |
| Depositing User: | [Miss Valerie McCutcheon](https://eprints.gla.ac.uk/profile/12688) |
| Datestamp: | 02 Dec 2019 15:04 |
| Last Modified: | 29 Oct 2024 13:28 |
| Date of acceptance: | 15 November 2019 |
| Date of first online publication: | 9 December 2019 |
| Date Deposited: | 2 December 2019 |
| Data Availability Statement: | No |
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