You talking to me? Cadherin and integrin crosstalk in biomaterials design

Source: https://eprints.gla.ac.uk/232666/ Parent: https://eprints.gla.ac.uk/view/project_code/303613.html

You talking to me? Cadherin and integrin crosstalk in biomaterials design

Barcelona Estaje, Eva, Dalby, Matthew J. ORCID: https://orcid.org/0000-0002-0528-3359, Cantini, Marco ORCID: https://orcid.org/0000-0003-0326-1508 and Salmeron-Sanchez, Manuel ORCID: https://orcid.org/0000-0002-8112-2100 (2021) You talking to me? Cadherin and integrin crosstalk in biomaterials design. Advanced Healthcare Materials, 10(6), 2002048. (doi: 10.1002/adhm.202002048) (PMID:33586353)


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Abstract

While much work has been done in the design of biomaterials to control integrin‐mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell–cell contacts in combination with cell–matrix interactions are key in driving embryonic development, collective cell migration, epithelial to mesenchymal transition, and cancer metastatic processes, among others. This review focuses on the incorporation of both cadherin and integrin ligands in biomaterial design, to promote what is called the “adhesive crosstalk.” First, the structure and function of cadherins and their role in eliciting mechanotransductive processes, by themselves or in combination with integrin mechanosensing, are introduced. Then, biomaterials that mimic cell–cell interactions, and recent applications to get insights in fundamental biology and tissue engineering, are critically discussed.


Item Type:	Articles
Additional Information:	This work was supported by an EPSRC Programme Grant (No. EP/P001114/1). The authors acknowledge support from a grant from the UK Regenerative Medicine Platform “Acellular/Smart Materials – 3D Architecture” (Grant No. MR/R015651/1) and MRC funding (Grant No. MR/S005412/1).
Status:	Published
Refereed:	Yes
Glasgow Author(s) Enlighten ID:	Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Cantini, Dr Marco and Barcelona Estaje, Eva
Authors:	Barcelona Estaje, E., Dalby, M. J., Cantini, M., and Salmeron-Sanchez, M.
College/School:	College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:	Advanced Healthcare Materials
Publisher:	Wiley
ISSN:	2192-2640
ISSN (Online):	2192-2659
Published Online:	15 February 2021
Copyright Holders:	Copyright © 2021 The Authors
First Published:	First published in Advanced Healthcare Materials 10(6):2002048
Publisher Policy:	Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Funder and Project Information

Project Code

Award No

Project Name

Principal Investigator

Funder's Name

Funder Ref

Lead Dept

173192

Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine

Manuel Salmeron-Sanchez

Engineering and Physical Sciences Research Council (EPSRC)

EP/P001114/1

ENG - Biomedical Engineering

301095

UKRMP2 Acellular/Smart Materials 3D Architecture Hub

Manuel Salmeron-Sanchez

Medical Research Council (MRC)

MMRE_P75176 (MR/R015651/1

ENG - Biomedical Engineering

303613

Engineered microenvironments to harvest stem cell response to viscosity for cartilage repair

Marco Cantini

Medical Research Council (MRC)

MR/S005412/1

ENG - Biomedical Engineering

Deposit and Record Details


ID Code:	232666
Depositing User:	Ms Jacqui Brannan
Datestamp:	26 Jan 2021 12:29
Last Modified:	19 Dec 2025 14:07
Date of acceptance:	25 January 2021
Date of first online publication:	15 February 2021
Date Deposited:	18 February 2021
Data Availability Statement:	No

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