# Eduardo S. Fricovsky, Pharm.D.

**Source**: https://pharmacy.ucsd.edu/faculty/fricovsky
**Parent**: https://pharmacy.ucsd.edu/admissions/career-opportunities

#### Health Sciences Clinical Professor of Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences

Email

esfricovsky@health.ucsd.edu

Phone

(858) 534-3714

Research Summary

Dr. Fricovsky’s research interest includes diabetic cardiomyopathy and the effects of enzymatic protein glycosylation (O-GlcNAc) in type 2 diabetic mouse hearts and their influence on cardiac function. Also, conducts studies related to the expression of O-GlcNAcase (GCA) an enzyme that removes excessive O-GlcNAc modification and protection against diabetic cardiomyopathy. Furthermore, he examines the role of GCA gene expression and O- GlcNAc levels in non-diabetics and diabetic patients at the UC San Diego Student-Run Free Clinic.

Academic Achievements

**Education**: B.S. in Biochemistry/Chemistry (2002) UC San Diego; UCSF School of Pharmacy (2006); NIH T32 Research Fellow (2006-2009) UC San Diego, Department of Medicine.

**Awards and Honors**: ASHP Outstanding Professional Development Project Award (2014); American Pharmacy Association National Immunization Champion Award (2014); UC San Diego Student Run Free Clinics Community Leadership Award (2013); UC San Diego Health Science Academic Senate Research Award (2012) UC San Diego Student Run Free Clinic Angel Award (2012); Society of Chemical Industry Teacher Award (2011); UC San Diego Skaggs School of Pharmacy Excellence in Teaching Award (2009-2010); UC San Diego Student Run Free Clinic Project Clinical Leader Award (2009); UC San Diego Student Run Free Clinic Project Pharmacy Faculty Leader Award (2008).

**Leadership Experience**: Founder and President of the UCSF Latino Association of Pharmacy Students (LAPS) (2003- 2005); UC San Diego Student Run Free Clinic Project Pharmacy Director (2009-Present); AdHoc SSPPS Non-Salary Faculty Review Committee (2009- Present); Co-Chair SSPPS ACTION Academic Communities (2010-Present); UC San Diego OASIS Alumni Committee Officer (2012-Present)

Teaching

- Pharmacy Therapeutics (SPPS 212A).
- Pharmacy Practice (SPPS 201, 202, 203).
- Pharmacy Preceptor: UC San Diego Student-Run Free Clinic Project (IPPE & APPE).

Selected Publications

- Suarez et al. (2008). [Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardio-myocytes. *Am J Physiol Cell Physiol.* 295:C1561-C1568.](http://ajpcell.physiology.org/content/295/6/C1561.abstract)
- \*Romero-Perez et al. (2008). [Cardiac uptake of minocycline and mechanisms for in vivo cardioprotection. *J Am Col Cardiol.* 52:1086-1094.](http://content.onlinejacc.org/article.aspx?articleid=1139238&issueno=13)\
  \* Shared first co-First Author.
- Hu et al. (2009).[Increased enzymatic O- GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose.*J Biol Chem*. 284:547-555.](http://www.jbc.org/gca?gca=jbc%3B284%2F1%2F547&submit=Get+All+Checked+Abstracts)
- Griffin et al. (2010). [Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature.*Am J Physiol Cell Physiol*.](http://www.ncbi.nlm.nih.gov/pubmed/20951211)
- Fricovsky et al. (2012). [Excess protein O- GlcNAcylation and the progression of diabetic cardiomyopathy. *Am J Physiol Regul Integr Comp Physio*l. 303:R689-99](http://www.ncbi.nlm.nih.gov/pubmed/22874425)
- Suarez et al. (2013). [Sorcin modulates mitochondrial Ca2+ handling and reduces apoptosis in neonatal rat cardiac myocytes.*Am J Physiol Cell Physiol*. 304:C248-56.](http://www.ncbi.nlm.nih.gov/pubmed/23151801)
- \*Aguilar et al. (2014). [Role for high glucose induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis.*Am J Physiol Cell Physiol.* 306(9):C794-804](http://www.ncbi.nlm.nih.gov/pubmed/24553187).\
  \* Shared first co-First Author.

**[(view more)](https://pubmed.ncbi.nlm.nih.gov/?term=fricovsky+e)**