ISREC Foundation awards TANDEM Grant to Andreas Moor and clinical colleague

Source: https://bsse.ethz.ch/news-and-events/d-bsse-news/2025/10/isrec-foundation-awards-tandem-grant-to-andreas-moor-and-clinical-colleague.html Parent: https://bsse.ethz.ch/news-and-events/d-bsse-news.html?AUTHOR=Q2Fyb2xpbiBBcm5kdCBGb3BwYQ&path=L2NvbnRlbnQvc3BlY2lhbGludGVyZXN0L2Jzc2UvZGVwYXJ0bWVudC9lbi9uZXdzLWFuZC1ldmVudHMvamNyOmNvbnRlbnQvcGFyL25ld3NmZWVkXzQzMTg

Congratulations to Andreas Moor, Head of the Systems Physiology lab at D-BSSE, and Viktor Kölzer from the University Hospital Basel for receiving a TANDEM grant for their ‘advanced digital pathology in cancer’ project. Their interdisplinary research focusses on the discovery of new prognostic markers that are correlated with the outcome of the disease in colon-cancer patients. Ultimately, the team hopes to pave the way for advanced diagnostics and personalised cancer treatments.

This project uses cutting-edge spatial technology to create high-resolution maps of gene activity directly within tissue slices, allowing the team around Andreas Moor to characterise the spatial architecture of colorectal cancer. This illustration shows how the researchers translate raw spatial 'omics' data into diagrams of cells and their interactions. By precisely profiling where genes are active, and combining this data with clinical outcome records, the goal is to uncover new biomarkers – molecular signatures – that will enable more accurate prediction of patient outcomes and help personalise treatment strategies.

In order to identify prognostic biomarkers for stage II colorectal cancers (CRC), the investigators will use computational approaches to combine advanced molecular ‘omics data with histological images from 1800 past CRC patients. The goal will be to identify prognostic markers in networks, and to validate these on new cohorts of patients.

TANDEM Grants are awarded by the ISREC Fondation Recherche Cancer. Jointly led by a clinician and a basic research scientist, the awarded research aims to advance clinical translation in the field of cancer pathology.

Find news post on external page this year’s TANDEM Grant winners.

Learn about research in the Systems Physiology lab led by Andreas Moor.