# Andreas Moor receives the Swiss Bridge Award 2025 for his research on colorectal cancer progression

**Source**: https://bsse.ethz.ch/news-and-events/d-bsse-news/2025/11/andreas-moor-receives-the-swiss-bridge-award-2025-for-his-research-on-colorectal-cancer-progression.html
**Parent**: https://bsse.ethz.ch/news-and-events/d-bsse-news.html?AUTHOR=Q2Fyb2xpbiBBcm5kdCBGb3BwYQ&path=L2NvbnRlbnQvc3BlY2lhbGludGVyZXN0L2Jzc2UvZGVwYXJ0bWVudC9lbi9uZXdzLWFuZC1ldmVudHMvamNyOmNvbnRlbnQvcGFyL25ld3NmZWVkXzQzMTg

The SWISS BRIDGE Foundation selected Andreas Moor’s project for its innovative approach in the field of precision oncology. The prize money is intended to contribute to the development of more targeted and effective cancer therapies. In his research, Andreas focusses on cellular interactions in cancer with the aim to identify new targets and biomarkers. Congratulations, Andreas!

Excerpt from the SWISS BRIDGE Foundation's Media Release:

The team led by Prof. Moor is researching innovative approaches to preventing liver metastases in colorectal cancer, which occurs in around one third of all patients and significantly increases mortality. The researchers have discovered that a protein called PlexinB2 on liver cells promotes the spread of colorectal cancer to the liver. To specifically prevent this progression, the team has developed "smart" molecules that recognise and break down PlexinB2 and similar metastasis-promoting proteins in liver cells. "We use a special delivery protein that serves as a navigation aid for the liver and combine it with a mini-protein that specifically binds to target proteins such as PlexinB2. This allows them to be selectively destroyed," explains Prof. Moor. The aim of the project is to develop several of these smart protein molecules, improve their effectiveness and test them in animal models. This innovative approach could help prevent liver metastases in the future and thus significantly improve treatment outcomes for colorectal cancer.

The [external page SWISS BRIDGE Foundation](https://www.swissbridge.ch/swiss-bridge-award) is investing in innovative and high-quality research projects.

Find out about [research in the Systems Physiology Lab led by Andreas Moor.](https://bsse.ethz.ch/lsp/research.html)