Group Luttge
Source: https://www.tue.nl/en/research/research-groups/microsystems/group-luttge Parent: https://www.tue.nl/en/research/research-groups/microsystems
Group of Microsystems
Group Luttge
As part of the Mechanical Engineering department, our cross-disciplinary research group investigates and develops microsystems for medicine and biology with integrated bio-inspired functionality. We apply emerging and established micro-nanofabrication methods. The specific goal is to combine microfluidics with tissue engineering to create a realistic in vitro model of the brain, which can provide insights into both normal and disease-state function. To forward-engineer a living brain-on-chip from neuronal stem cells, we design, realize, test artificial micro-environments with a focus on their physiological relevance.
Temporal and spatial control of the cellular microenvironment is key to developing physiological and clinically relevant platform technologies for the prevention, relief and cure of human diseases. Hence, the understanding of critical design rules for bio
As part of the Microsystems section, we designs microsystems for medicine and biology with a focus on brain research. We develop and study micro-nanofabrication methods to devise miniaturized in vivo-like brain models using neuronal stem cell in culture and study new applications of this so called brain-on-a-chip technologies.
News
[March 5, 2026
Control of novel power exhaust solutions in nuclear fusion
Bob Kool defended his PhD thesis at the Department of Mechanical Engineering on March 5.
Read more](https://www.tue.nl/en/news-and-events/news-overview/05-03-2026-control-of-novel-power-exhaust-solutions-in-nuclear-fusion) [March 4, 2026
Can a robot think without electronics?
Sergio Picella defended his PhD thesis at the Department of Mechanical Engineering on March 4th.
Read more](https://www.tue.nl/en/news-and-events/news-overview/04-03-2026-can-a-robot-think-without-electronics)
More news
[Time-dependent modeling of plasma exhaust in fusion reactors
March 3, 2026](https://www.tue.nl/en/news-and-events/news-overview/03-03-2026-time-dependent-modeling-of-plasma-exhaust-in-fusion-reactors) [Advancing metal powder production with computer modeling
March 2, 2026](https://www.tue.nl/en/news-and-events/news-overview/02-03-2026-advancing-metal-powder-production-with-computer-modeling) [Advancing clean heat with District Heating and Cooling systems
February 25, 2026](https://www.tue.nl/en/news-and-events/news-overview/25-02-2026-advancing-clean-heat-with-district-heating-and-cooling-systems) [Young researcher in the spotlight: Tommaso Magrini
February 24, 2026](https://www.tue.nl/en/news-and-events/news-overview/24-02-2026-young-researcher-in-the-spotlight-tommaso-magrini)
Meet some of our Researchers
[Postdoc
Rahman Sabahi Kaviani](https://www.tue.nl/en/research/researchers/rahman-sabahi-kaviani)[Associate Professor
Regina Luttge](https://www.tue.nl/en/research/researchers/regina-luttge)
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Recent Publications
Our most recent peer reviewed publications
- [### Nervous System-on-Chip
Micromachines
(2026)
Rahman Sabahi-Kaviani,Antigoni Gogolou,Celine Souilhol,Mark van der Kroeg,Steven A. Kushner,Femke M.S. de Vrij,Anestis Tsakiridis,Regina Luttge](https://research.tue.nl/nl/publications/3e9440bc-faec-4ff2-bfaf-899c1dce36f8) - [### Mechanodynamic brain on chip for studying human stem cell derived neuronal networks
Scientific Reports
(2025)
Gulden Akcay,Regina Luttge](https://research.tue.nl/nl/publications/075dadc6-71bb-4e8c-9151-8339829af0f0) - [### Integrating Macroethics into Engineering Education
2025 IEEE International Symposium on Ethics in Engineering, Science, and Technology, ETHICS 2025
(2025)
Diana Adela Martin,Gunter Bombaerts,Adam Watkins,Regina Lüttge](https://research.tue.nl/nl/publications/fe6ca260-bdc1-4066-9b2f-7ef95e024559) - [### α-Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science
(2025)
Gemma Gomez-Giro,Daniela Frangenberg,Daniela Vega,Alise Zagare,Kyriaki Barmpa,Paul M.A. Antony,Graham Robertson,Rahman Sabahi-Kaviani,Kristian Haendler,Nathalie Kruse](https://research.tue.nl/nl/publications/6b0fc907-cda6-4832-968a-ed050f93afc6) - [### Integrating Macroethics into Engineering Education
2025 IEEE International Symposium on Ethics in Engineering, Science, and Technology, ETHICS 2025
(2025)
Diana Adela Martin,Gunter Bombaerts,Adam Watkins,Regina Luttge](https://research.tue.nl/nl/publications/2fbffbc0-e204-4185-9016-029e9054d52c)
Contact
-
Visiting address
Gemini-Zuid, 3.128
Groene Loper 3
5612 AE Eindhoven
Netherlands - ### Visiting address
Gemini-Zuid, 3.128
Groene Loper 3
5612 AE Eindhoven
Netherlands - ### Visiting address
Department of Mechanical Engineering
P.O. Box 513
5600 MB Eindhoven
Netherlands - ### Visiting address
Department of Mechanical Engineering
P.O. Box 513
5600 MB Eindhoven
Netherlands - ###
Teamlead