Bio-Data Science and Physics-Informed AI

Source: https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra7-bio-data-science-and-physics-inspired-ai Parent: https://physics-of-life.tu-dresden.de/

Research Avenue 7

Bio-Data Science and Physics-Informed AI

Data-analysis and computational modeling play a fundamental role in linking theory and experiment. They help to generate testable hypotheses, interpret experimental data, study nonlinear models and are essential for testing the adequacy of physical theories. We envision novel computational methods, often based on AI algorithms, that are required to extract hidden patterns from data in the non-equilibrium, nonlinear, and multiscale systems studied at PoL.

Our aim will be to develop novel data analysis, machine learning, and scientific computing methods, with a focus on algorithmic innovations designed from the ground up, to cope with the complexity of living systems. We will integrate theory-driven numerical simulations with data-driven inference, resulting in physics-informed bio-data science. The mathematical foundations of topological data analysis will also be expanded, and used to understand these systems.

Research Topic 1

Revealing the High-Order Structures of Discrete Biological Data

Research Topic 2

Deep Learning for Biomolecular Grammar

Research Topic 3

Data-driven Modeling and Simulation

Research Topic 4

Bio-image Artificial Intelligence

RA Leading Team

Ivo F. Sbalzarini (RA Leader)

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

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(RA Leader) in a new tab

Heather Harrington (RA Co-Leader)

MPI-CBG, CSBD | Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford

Algebraic Systems Biology

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(RA Co-Leader) in a new tab

Ágnes Tóth-Petróczy

MPI-CBG | Research Group Leader

Protein plasticity and evolution

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PoL Groups

Simon Alberti

TUD BIOTEC | Professor for Cellular Biochemistry

Organization of cytoplasm across space and time

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Otger Campàs

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

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Adele Doyle

Research Group Leader

Mechanobiology of Stem Cells

hired by PoL

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Benjamin Friedrich

Heisenberg Professor for Biological Algorithms

Biological Algorithms: Spatio-Temporal Dynamics of Cells and Tissues

hired by PoL

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Anne Grapin-Botton

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

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Stephan W. Grill

MPI-CBG | Director of MPI-CBG, Professor for Physics of Life

Physics of Life

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Heather Harrington

MPI-CBG, CSBD | Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford

Algebraic Systems Biology

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Alf O. Honigmann

TUD BIOTEC | Professor for Biophysics

Membrane Organization of Cells and Tissues

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Meritxell Huch

MPI-CBG | Director of MPI-CBG, Lise Meitner Max Planck Research Group Leader

Organoids, tissue regeneration and its deregulation in disease

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Anthony A. Hyman

MPI-CBG | Director of MPI-CBG, Professor for Molecular Cell Biology

Organization of Cytoplasm

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Frank Jülicher

MPI-PKS | Director of MPI-PKS, Professor for Biophysics

Dynamic processes in cells and tissues

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Christina Kurzthaler

MPI-PKS, CSBD | Research Group Leader

Transport and Flows in Complex Environments

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Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

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Ágnes Tóth-Petróczy

MPI-CBG | Research Group Leader

Protein plasticity and evolution

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Xingbo Yang

Research Group Leader

Bioenergetics of Self-Organization

hired by PoL

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PoL Associates

Sebastian Aland

HTWD | Professor for Numerical Analysis

Modeling and Simulation of Biological Interfaces

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Jürgen Czarske

TUD | Professor for Measurement and Sensor Systems

Biomedical Computational Laser Systems (BIOLAS): Adaptive Smart Microscopy

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Thomas Kühne

TUD, CASUS, HZDR | Director of CASUS, Professor for Computational Systems Science

Sustainable Systems Science, Theory of Complex Systems

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Stefanie Speidel

NCT/UCC, CeTI, TUD | Professor for Translational Surgical Oncology

Machine learning for computer/robot-assisted surgery

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Pavel Tomancak

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

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Axel Voigt

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

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Alexander von Appen

MPI-CBG | Research Group Leader

Structural Self-Organization of Membranous Organelles

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Martin Weigert

TUD, ScaDS.AI | Chair of Machine Learning for Spatial Understanding

AI & Computer Vision for Quantitative Microscopy

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Artur Yakimovich

CASUS, HZDR | Research Group Leader

Machine Learning for Infection and Disease

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