# Bio-Data Science and Physics-Informed AI
**Source**: https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra7-bio-data-science-and-physics-inspired-ai
**Parent**: https://physics-of-life.tu-dresden.de/
Research Avenue 7
- [Research Avenue 1RA1](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra1-collective-transitions-in-multicellular-systems "Collective Transitions in Multicellular Systems")
- [Research Avenue 2RA2](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra2-emergent-cellular-phases "Emergent Cellular Phases")
- [Research Avenue 3RA3](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra3-self-organizing-active-molecular-systems "Self-Organizing Active Molecular Systems")
- [Research Avenue 4RA4](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra4-energy-and-information-flows-in-active-matter "Energy and Information Flows in Active Matter")
- [Research Avenue 5RA5](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra5-physical-measurements-in-intact-living-systems "Physical Measurements in Intact Living Systems")
- [Research Avenue 6RA6](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra6-engineering-living-matter "Engineering Living Matter")
# Bio-Data Science and Physics-Informed AI
Data-analysis and computational modeling play a fundamental role in linking theory and experiment. They help to generate testable hypotheses, interpret experimental data, study nonlinear models and are essential for testing the adequacy of physical theories. We envision novel computational methods, often based on AI algorithms, that are required to extract hidden patterns from data in the non-equilibrium, nonlinear, and multiscale systems studied at PoL.
**Our aim** will be to develop novel data analysis, machine learning, and scientific computing methods, with a focus on algorithmic innovations designed from the ground up, to cope with the complexity of living systems. We will integrate theory-driven numerical simulations with data-driven inference, resulting in physics-informed bio-data science. The mathematical foundations of topological data analysis will also be expanded, and used to understand these systems.
Research Topic 1
Revealing the High-Order Structures of Discrete Biological Data
Research Topic 2
Deep Learning for Biomolecular Grammar
Research Topic 3
Data-driven Modeling and Simulation
Research Topic 4
Bio-image Artificial Intelligence
## RA Leading Team
### Ivo F. Sbalzarini (RA Leader)
TUD, CSBD
| Professor for Scientific Computing for Systems Biology
The MOSAIC Group: Scientific Computing for Image-based Systems Biology
[›› open the website of Ivo F. Sbalzarini<br>(RA Leader) in a new tab](http://mosaic.mpi-cbg.de "›› open the website of Ivo F. Sbalzarini<br>(RA Leader) in a new tab")
© MPI-CBG
### Heather Harrington (RA Co-Leader)
MPI-CBG, CSBD
| Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford
Algebraic Systems Biology
[›› open the website of Heather Harrington<br>(RA Co-Leader) in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/heather-harrington/group-leader "›› open the website of Heather Harrington<br>(RA Co-Leader) in a new tab")
© Z Goriely
### Ágnes Tóth-Petróczy
MPI-CBG
| Research Group Leader
Protein plasticity and evolution
[›› open the website of Ágnes Tóth-Petróczy in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/agnes-toth-petroczy/ "›› open the website of Ágnes Tóth-Petróczy in a new tab")
© MPI-CBG
## PoL Groups
### Simon Alberti
TUD BIOTEC
| Professor for Cellular Biochemistry
Organization of cytoplasm across space and time
[›› open the website of Simon Alberti in a new tab](https://tu-dresden.de/cmcb/biotec/forschungsgruppen/alberti?set_language=en "›› open the website of Simon Alberti in a new tab")
© MPI-CBG
### Otger Campàs
Chair of Tissue Dynamics
Physics of Embryonic Self-Organization and Morphogenesis
hired by PoL
[›› visit the website of Otger Campàs](https://physics-of-life.tu-dresden.de/team/pol-groups/campas "›› visit the website of Otger Campàs")
### Adele Doyle
Research Group Leader
Mechanobiology of Stem Cells
hired by PoL
[›› visit the website of Adele Doyle](https://physics-of-life.tu-dresden.de/team/pol-groups/doyle "›› visit the website of Adele Doyle")
### Benjamin Friedrich
Heisenberg Professor for Biological Algorithms
Biological Algorithms: Spatio-Temporal Dynamics of Cells and Tissues
hired by PoL
[›› visit the website of Benjamin Friedrich](https://physics-of-life.tu-dresden.de/team/pol-groups/friedrich "›› visit the website of Benjamin Friedrich")
### Anne Grapin-Botton
MPI-CBG
| Director of MPI-CBG
Self-organization of cells into organ communities
[›› open the website of Anne Grapin-Botton in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/anne-grapin-botton/ "›› open the website of Anne Grapin-Botton in a new tab")
© MPI-CBG
### Stephan W. Grill
MPI-CBG
| Director of MPI-CBG, Professor for Physics of Life
Physics of Life
[›› open the website of Stephan W. Grill in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/stephan-grill/ "›› open the website of Stephan W. Grill in a new tab")
© MPI-CBG
### Heather Harrington
MPI-CBG, CSBD
| Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford
Algebraic Systems Biology
[›› open the website of Heather Harrington in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/heather-harrington/group-leader "›› open the website of Heather Harrington in a new tab")
© Z Goriely
### Alf O. Honigmann
TUD BIOTEC
| Professor for Biophysics
Membrane Organization of Cells and Tissues
[›› open the website of Alf O. Honigmann in a new tab](https://tu-dresden.de/cmcb/biotec/forschungsgruppen/honigmann "›› open the website of Alf O. Honigmann in a new tab")
### Meritxell Huch
MPI-CBG
| Director of MPI-CBG, Lise Meitner Max Planck Research Group Leader
Organoids, tissue regeneration and its deregulation in disease
[›› open the website of Meritxell Huch in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/meritxell-huch/ "›› open the website of Meritxell Huch in a new tab")
© MPI-CBG
### Anthony A. Hyman
MPI-CBG
| Director of MPI-CBG, Professor for Molecular Cell Biology
Organization of Cytoplasm
[›› open the website of Anthony A. Hyman in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/anthony-hyman/ "›› open the website of Anthony A. Hyman in a new tab")
© Sven Döring
### Frank Jülicher
MPI-PKS
| Director of MPI-PKS, Professor for Biophysics
Dynamic processes in cells and tissues
[›› open the website of Frank Jülicher in a new tab](https://www.pks.mpg.de/biological-physics/frank-juelicher/ "›› open the website of Frank Jülicher in a new tab")
© MPI-CBG
### Christina Kurzthaler
MPI-PKS, CSBD
| Research Group Leader
Transport and Flows in Complex Environments
[›› open the website of Christina Kurzthaler in a new tab](https://www.pks.mpg.de/tfce "›› open the website of Christina Kurzthaler in a new tab")
© MPI-CBG
### Ivo F. Sbalzarini
TUD, CSBD
| Professor for Scientific Computing for Systems Biology
The MOSAIC Group: Scientific Computing for Image-based Systems Biology
[›› open the website of Ivo F. Sbalzarini in a new tab](http://mosaic.mpi-cbg.de "›› open the website of Ivo F. Sbalzarini in a new tab")
© MPI-CBG
### Ágnes Tóth-Petróczy
MPI-CBG
| Research Group Leader
Protein plasticity and evolution
[›› open the website of Ágnes Tóth-Petróczy in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/agnes-toth-petroczy/ "›› open the website of Ágnes Tóth-Petróczy in a new tab")
© MPI-CBG
### Xingbo Yang
Research Group Leader
Bioenergetics of Self-Organization
hired by PoL
[›› visit the website of Xingbo Yang](https://physics-of-life.tu-dresden.de/team/pol-groups/yang "›› visit the website of Xingbo Yang")
## PoL Associates
### Sebastian Aland
HTWD
| Professor for Numerical Analysis
Modeling and Simulation of Biological Interfaces
[›› open the website of Sebastian Aland in a new tab](https://alandlab.de/ "›› open the website of Sebastian Aland in a new tab")
### Jürgen Czarske
TUD
| Professor for Measurement and Sensor Systems
Biomedical Computational Laser Systems (BIOLAS): Adaptive Smart Microscopy
[›› open the website of Jürgen Czarske in a new tab](https://tu-dresden.de/ing/elektrotechnik/iee/mst "›› open the website of Jürgen Czarske in a new tab")
© Center BIOLAS, TUD
### Thomas Kühne
TUD, CASUS, HZDR
| Director of CASUS, Professor for Computational Systems Science
Sustainable Systems Science, Theory of Complex Systems
[›› open the website of Thomas Kühne in a new tab](https://www.casus.science/?page_id=4229 "›› open the website of Thomas Kühne in a new tab")
### Stefanie Speidel
NCT/UCC, CeTI, TUD
| Professor for Translational Surgical Oncology
Machine learning for computer/robot-assisted surgery
[›› open the website of Stefanie Speidel in a new tab](http://nct-dresden.de/tso "›› open the website of Stefanie Speidel in a new tab")
© Gabriele Bellmann, UKD
### Pavel Tomancak
MPI-CBG
| Research Group Leader
Patterns of gene expression in animal development
[›› open the website of Pavel Tomancak in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/pavel-tomancak/ "›› open the website of Pavel Tomancak in a new tab")
© MPI-CBG
### Axel Voigt
TUD
| Professor for Scientific Computing and Applied Mathematics
Mathematical Modeling and Numerical Simulation of Cells and Systems
[›› open the website of Axel Voigt in a new tab](https://tu-dresden.de/mn/math/wir "›› open the website of Axel Voigt in a new tab")
© MPI-CBG
### Alexander von Appen
MPI-CBG
| Research Group Leader
Structural Self-Organization of Membranous Organelles
[›› open the website of Alexander von Appen in a new tab](https://www.mpi-cbg.de/research/researchgroups/currentgroups/alexander-von-appen "›› open the website of Alexander von Appen in a new tab")
© MPI-CBG
### Martin Weigert
TUD, ScaDS.AI
| Chair of Machine Learning for Spatial Understanding
AI & Computer Vision for Quantitative Microscopy
[›› open the website of Martin Weigert in a new tab](https://weigertlab.org/ "›› open the website of Martin Weigert in a new tab")
### Artur Yakimovich
CASUS, HZDR
| Research Group Leader
Machine Learning for Infection and Disease
[›› open the website of Artur Yakimovich in a new tab](https://www.hzdr.de/db/!ContMan.Visi.Card?pUser=151692&pNid=1227&pLang=en "›› open the website of Artur Yakimovich in a new tab")
- [Research Avenue 1RA1](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra1-collective-transitions-in-multicellular-systems "Collective Transitions in Multicellular Systems")
- [Research Avenue 2RA2](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra2-emergent-cellular-phases "Emergent Cellular Phases")
- [Research Avenue 3RA3](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra3-self-organizing-active-molecular-systems "Self-Organizing Active Molecular Systems")
- [Research Avenue 4RA4](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra4-energy-and-information-flows-in-active-matter "Energy and Information Flows in Active Matter")
- [Research Avenue 5RA5](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra5-physical-measurements-in-intact-living-systems "Physical Measurements in Intact Living Systems")
- [Research Avenue 6RA6](https://physics-of-life.tu-dresden.de/research/vision-research-avenues/ra6-engineering-living-matter "Engineering Living Matter")