Yale University

Source: https://cbic.yale.edu/instruments-listing?field_instrument_type_value=NMR+%26+EPR Parent: https://cbic.yale.edu/instruments

Instrument Catalog

Instrument Type

Any -Diffraction (X-ray and electron)ImagingMass SpectrometryNMR & EPROptical SpectroscopyScatteringSolution BiophysicsStructural Science

Instrument Location

Any -CRB 100KCL 3KCL 7KCL 11KCL 12KCL 16BSCL 148SCL 136SCL 123SCL 123aSCL 26

Sort by Instrument NameDate of AcquisitionInstrument Type

Order AscDesc

500wb Bruker Neo 500 MHz NMR spectrometer

Short Name: V500wb

Instrument Type: NMR & EPR

Instrument Location: CRB 100

Date of Acquisition: December 1995

500 MHz wide-bore NMR spectrometer.

3.2 mm CPMAS probe normally installed for solid-state NMR experiments.

Micro MRI imaging capabilities

A400a Agilent DD2 400 MHz NMR Spectrometer (Autosampler)

Short Name: A400a

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: August 2013

2 channel system with AS7620 96-sample changer. OneNMR\ probe with auto-tune-and-match installed.

Undergraduates have priority on this instrument during lab periods.

Guides and Standard Operating Procedures

Best experiments:

PROTON
COSY
Other nuclei: F19 (no H1 decoupling), P31, B11, (others by request)

Acceptable experiments:

C13CPD (night time)
2D HSQC and HMBC experiments
1D/2D NOE experiments

Not available:

Variable Temperature experiments
Kinetics experiments
Simultaneous F19 and H1 experiments

Time Required for NMR Experiments on A400a:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	10 h 40 min	35389 hours	1785 hours	1886 hours	7129 hours
0.06 mg	0.2 mM	2 h 40 min	10516 hours	46 h 28 min	474 h 12 min	1785 hours
0.15 mg	0.5 mM	0 h 26 min	1415 h 33 min	6 h 10 min	75 h 01 min	284 h 44 min
0.3 mg	1 mM	0 h 06 min	354 h 01 min	1 h 40 min	18 h 53 min	71 h 19 min
0.6 mg	2 mM	0 h 01 min	88 h 31 min	0 h 26 min	4 h 42 min	17 h 51 min
1.5 mg	5 mM	< 1 min	14 h 09 min	0 h 03 min	0 h 45 min	2 h 51 min
3 mg	10 mM	< 1 min	3 h 32 min	0 h 03 min	0 h 16 min	1 h 07 min
6 mg	20 mM	< 1 min	0 h 53 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 13 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 08 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A400b Agilent DD2 400 MHz NMR Spectrometer (Manual)

Short Name: A400b

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: October 2013

2 channel system. AutoX DB probe installed. Variable-temperature and H/F experiments available.

Guides and Standard Operating Procedures

Best experiments:

PROTON
Simultaneous F19 and H1 experiments (i.e. F19 with H1 decoupling)
Variable Temperature experiments (with appropriate CBIC training)
Kinetics experiments

Acceptable experiments:

C13CPD
2D HSQC and HMBC experiments
1D/2D NOE experiments

Not available:

Nuclei other than H1, F19 & C13

Time Required for NMR Experiments on A400b:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	44 h 44 min	50960 hours	644 hours	7862 hours	29844 hours
0.06 mg	0.2 mM	11 h 11 min	12740 hours	161 hours	1965 hours	7461 hours
0.15 mg	0.5 mM	1 h 47 min	2038 h 24 min	25 h 47 min	319 h 18 min	1193 h 57 min
0.3 mg	1 mM	0 h 27 min	509 h 36 min	6 h 30 min	78 h 37 min	298 h 40 min
0.6 mg	2 mM	0 h 07 min	127 h 27 min	1 h 38 min	19 h 48 min	75 h 40 min
1.5 mg	5 mM	0 h 01 min	20 h 23 min	0 h 16 min	3 h 08 min	12 h 15 min
3 mg	10 mM	< 1 min	5 h 15 min	0 h 06 min	0 h 47 min	1 h 32 min
6 mg	20 mM	< 1 min	1 h 16 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 19 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 12 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A400c Agilent DD2 400 MHz NMR Spectrometer (Autosampler)

Short Name: A400c

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: October 2013

2 channel system with AS7620 96-sample changer. OneNMR probe with auto-tune-and-match installed.

Primarily used for short, routine NMR experiments where data is needed quickly.

Guides and Standard Operating Procedures

Best experiments:

PROTON
COSY
Other nuclei: F19 (no H1 decoupling), P31, B11, (others by request)

Acceptable experiments:

C13CPD (night time)
2D HSQC and HMBC experiments (night time)
1D/2D NOE experiments (night time)

Not available:

Variable Temperature experiments
Kinetics experiments
Simultaneous F19 and H1 experiments

Time Required for NMR Experiments on A400c:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	10 h 40 min	35389 hours	1785 hours	1886 hours	7129 hours
0.06 mg	0.2 mM	2 h 40 min	10516 hours	46 h 28 min	474 h 12 min	1785 hours
0.15 mg	0.5 mM	0 h 26 min	1415 h 33 min	6 h 10 min	75 h 01 min	284 h 44 min
0.3 mg	1 mM	0 h 06 min	354 h 01 min	1 h 40 min	18 h 53 min	71 h 19 min
0.6 mg	2 mM	0 h 01 min	88 h 31 min	0 h 26 min	4 h 42 min	17 h 51 min
1.5 mg	5 mM	< 1 min	14 h 09 min	0 h 03 min	0 h 45 min	2 h 51 min
3 mg	10 mM	< 1 min	3 h 32 min	0 h 03 min	0 h 16 min	1 h 07 min
6 mg	20 mM	< 1 min	0 h 53 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 13 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 08 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A500a Agilent DD2 500 MHz NMR Spectrometer (Manual)

Short Name: A500a

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: January 2014

2 channel system, OneNMR probe with auto-tune-and-match installed.

Guides and Standard Operating Procedures

Best experiments:

PROTON
COSY
2D HSQC and HMBC experiments
1D/2D NOE experiments
Other nuclei: F19 (no H1 decoupling), P31, B11, (others by request)
Variable Temperature experiments
Kinetics experiments

Acceptable experiments:

C13CPD

Not available:

Simultaneous F19 and H1 experiments

Time Required for NMR Experiments on A500a:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	5 hours	16962 hours	67 h 16 min	820 h 42 min	3113 h 37 min
0.06 mg	0.2 mM	1 h 10 min	424 h 02 min	16 h 50 min	205 h 15 min	779 h 06 min
0.15 mg	0.5 mM	0 h 11 min	678 h 28 min	2 h 45 min	32 h 50 min	124 h 34 min
0.3 mg	1 mM	0 h 03 min	170 h 00 min	0 h 42 min	8 h 20 min	31 h 09 min
0.6 mg	2 mM	< 1 min	4 h 15 min	0 h 11 min	2 h 05 min	7 h 48 min
1.5 mg	5 mM	< 1 min	3 h 11 min	0 h 03 min	0 h 08 min	1 h 40 min
3 mg	10 mM	< 1 min	1 h 42 min	0 h 03 min	0 h 08 min	0 h 17 min
6 mg	20 mM	< 1 min	0 h 25 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 06 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A500b Agilent DD2 500 MHz NMR Spectrometer (Manual)

Short Name: A500b

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: September 2012

2 channel system, OneNMR probe with auto-tune-and-match installed.

Guides and Standard Operating Procedures

Best experiments:

PROTON
COSY
2D HSQC and HMBC experiments
1D/2D NOE experiments
Other nuclei: F19 (no H1 decoupling), P31, B11, (others by request)
Variable Temperature experiments
Kinetics experiments

Acceptable experiments:

C13CPD

Not available:

Simultaneous F19 and H1 experiments

Time Required for NMR Experiments on A500b:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	5 hours	16962 hours	67 h 16 min	820 h 42 min	3113 h 37 min
0.06 mg	0.2 mM	1 h 10 min	424 h 02 min	16 h 50 min	205 h 15 min	779 h 06 min
0.15 mg	0.5 mM	0 h 11 min	678 h 28 min	2 h 45 min	32 h 50 min	124 h 34 min
0.3 mg	1 mM	0 h 03 min	170 h 00 min	0 h 42 min	8 h 20 min	31 h 09 min
0.6 mg	2 mM	< 1 min	4 h 15 min	0 h 11 min	2 h 05 min	7 h 48 min
1.5 mg	5 mM	< 1 min	3 h 11 min	0 h 03 min	0 h 08 min	1 h 40 min
3 mg	10 mM	< 1 min	1 h 42 min	0 h 03 min	0 h 08 min	0 h 17 min
6 mg	20 mM	< 1 min	0 h 25 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 06 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A600a Agilent DD2 600 MHz NMR Spectrometer (Autosampler)

Short Name: A600a

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: October 2013

3 channel system with AS7510 12-sample automatic sample changer. C{H} cold probe with auto-tune-and-match installed. Highest sensitivity for C13 NMR experiments.

Guides and Standard Operating Procedures

Best experiments:

CARBON
PROTON

Acceptable experiments:

1D/2D NOE experiments

Not available:

Variable Temperature experiments
Kinetics experiments
Nuclei other than H1 and C13

Time Required for NMR Experiments on A600a:


Mass	Concentration	Proton	Carbon	gCOSY	gHSQC	gHMBC
0.03 mg	0.1 mM	0 h 24 min	1298 hours	5 h 54 min	72 h 04 min	272 h 22 min
0.06 mg	0.2 mM	0 h 06 min	324 h 32 min	1 h 28 min	19 h 35 min	68 h 32 min
0.15 mg	0.5 mM	0 h 01 min	51 h 56 min	0 h 16 min	3 h 11 min	11 h 10 min
0.3 mg	1 mM	< 1 min	13 h 00 min	0 h 03 min	0 h 47 min	2 h 47 min
0.6 mg	2 mM	< 1 min	3 h 15 min	0 h 03 min	0 h 16 min	1 h 07 min
1.5 mg	5 mM	< 1 min	0 h 31 min	0 h 03 min	0 h 08 min	0 h 34 min
3 mg	10 mM	< 1 min	0 h 08 min	0 h 03 min	0 h 08 min	0 h 17 min
6 mg	20 mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min
12 mg	40 mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min
15 mg	50 mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min
> 30 mg	100+ mM	< 1 min	0 h 04 min	0 h 03 min	0 h 08 min	0 h 17 min

All estimates based on a 500 MW sample in 600 uL solvent volume using a 5 mm diameter NMR tube

A800 Agilent 800 MHz NMR Spectrometer (Manual)

Short Name: A800

Instrument Type: NMR & EPR

Instrument Location: CRB 100

Date of Acquisition: July 2013

4 channel system. Inverse-detect HCN probe, Dual Band (direct-detect) probe, and H{CN} C13-sensitivity enhanced salt-tolerant cold probe available.

Experienced Users Only. Contact CBIC staff for more information.

EPR Bruker EleXsys EPR Spectrometer

Short Name: EPR

Instrument Type: NMR & EPR

Instrument Location: KCL 12

Date of Acquisition: September 2000

X-Band Electron Paramagnetic Resonance. Equipped with a cryogen-free cryostat.

V600a Varian VNMRS 600 MHz NMR Spectrometer (Manual)

Short Name: V600a

Instrument Type: NMR & EPR

Instrument Location: CRB 100

Date of Acquisition: July 2009

3 channel system. Inverse-detect HCN probe installed.

V600b Varian VNMRS 600 MHz NMR Spectrometer (Manual)

Short Name: V600b

Instrument Type: NMR & EPR

Instrument Location: CRB 100

Date of Acquisition: August 2002

3 channel system. Inverse-detect HCN probe installed.

V700 Varian Inova 700 MHz NMR Spectrometer (Manual)

Short Name: V300b

Instrument Type: NMR & EPR

Instrument Location: KCL 3

Date of Acquisition: October 2010

4 channel system, triple resonance probe normally installed.