上海交通大学生物医学工程学院
Source: https://bme.sjtu.edu.cn/Web/Show/2600 Parent: https://bme.sjtu.edu.cn/Web/Picture/346
科学研究
工程中心 重点实验室 校内平台 产学研联合基地 - 磁共振国家工程研究中心
中心概况 中心动态 平台建设 人才培养 仪器设备 - 临床转化中心 - 公共平台
纳米、分子及再生医学 平台 生物医疗仪器 影像、计算机系统生物学系统
Optical imaging of nanoparticles and direct control of calcium channels
发布时间：2021-12-14 19:18:00
Facilitated by nanofabrication and optical analysis techniques, the development of plasmonics has seen extensive applications in optical trapping, imaging, and biosensing. Based on interferometric plasmonic microscopy, an optical approach capable of imaging single exosomes in a label-free manner has been proposed, which contributes to clinical exosome analysis and further understanding of exosome–antibody binding kinetics. A method for direct control of Ca2+ channels, referred to as femtosecond laser activated store-operated calcium channel (femtoSOC), has been developed based on ultrafast laser without the need of optogenetic tools or any other exogenous reagents, hence alleviating the requirements of optogenetic activation of SOCs. A system to obtain quantitative amplitude and phase images in interferometric plasmonic microscopy has also been developed, which can be applied to bionanoparticle analysis and characterizing nanoplasmonic devices.
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Quantitative amplitude and phase imaging with interferometric plasmonic microscopy
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Selected Publications：
1. Yang Y, Shen G, Wang H, et al. Interferometric plasmonic imaging and detection of single exosomes. Proceedings of the National Academy of Sciences, 2018, 115(41): 10275-10280.
2. Cheng P, Tian X, Tang W, et al. Direct control of store-operated calcium channels by ultrafast laser. Cell Research, 2021, 31: 758–772.
3. Yang Y, Zhai C, Zeng Q, et al. Quantitative amplitude and phase imaging with interferometric plasmonic microscopy. ACS Nano, 2019, 13: 13595-13601.
4. Jiang X, Pu R, Wang C, et al. Noninvasive and early diagnosis of acquired brain injury using fluorescence imaging in the NIR-II window. Biomedical Optics Express, 2021, 12(11): 6984-6994.
5. Wang S, Liu Y, Zhang D, et al. Photoactivation of extracellular-signal-regulated kinase signaling in target cells by femtosecond laser. Laser & Photonics Reviews, 2018, 12: 1700137.