# 上海交通大学生物医学工程学院

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Optical imaging of nanoparticles and direct control of calcium channels

发布时间：2021-12-14 19:18:00

Facilitated by nanofabrication and optical analysis techniques, the
development of plasmonics has seen extensive applications in optical trapping,
imaging, and biosensing. Based on interferometric plasmonic microscopy, an
optical approach capable of imaging single exosomes in a label-free manner has
been proposed, which contributes to clinical exosome analysis and further
understanding of exosome–antibody binding kinetics. A method for direct control
of Ca2+ channels, referred to as femtosecond laser activated store-operated
calcium channel (femtoSOC), has been developed based on ultrafast laser without
the need of optogenetic tools or any other exogenous reagents, hence
alleviating the requirements of optogenetic activation of SOCs. A system to
obtain quantitative amplitude and phase images in interferometric plasmonic
microscopy has also been developed, which can be applied to bionanoparticle
analysis and characterizing nanoplasmonic devices.

\

**Quantitative amplitude and phase imaging with
interferometric plasmonic microscopy**

\

**Selected Publications****：**

1.       
Yang Y, Shen G, Wang H, et al. Interferometric plasmonic imaging and detection of single
exosomes. Proceedings of the National Academy of Sciences, 2018, 115(41):
10275-10280.

2.       
Cheng P, Tian X, Tang W, et al. Direct
control of store-operated calcium channels by ultrafast laser. Cell Research, 2021,
31: 758–772.

3.       
Yang Y, Zhai C, Zeng Q, et al. Quantitative
amplitude and phase imaging with interferometric plasmonic microscopy. ACS
Nano, 2019, 13: 13595-13601.

4.       
Jiang X, Pu R,
Wang C, et al. Noninvasive and early diagnosis of acquired brain injury using
fluorescence imaging in the NIR-II window. Biomedical Optics Express, 2021,
12(11): 6984-6994.

5.       
Wang S, Liu Y,
Zhang D, et al. Photoactivation of extracellular-signal-regulated kinase
signaling in target cells by femtosecond laser. Laser & Photonics Reviews,
2018, 12: 1700137.