ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells
Source: https://eprints.gla.ac.uk/227229/ Parent: https://eprints.gla.ac.uk/view/project_code/303613.html
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ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells
Walker, Matthew ORCID: https://orcid.org/0000-0001-5119-9118, Luo, Jiajun, Pringle, Eonan William and Cantini, Marco ORCID: https://orcid.org/0000-0003-0326-1508 (2021) ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells. Materials Science and Engineering C: Materials for Biological Applications, 121, 111822. (doi: 10.1016/j.msec.2020.111822) (PMID:33579465)
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Abstract
The extracellular matrix is a highly complex microenvironment, whose various components converge to regulate cell fate. Hydrogels, as water-swollen polymer networks composed by synthetic or natural materials, are ideal candidates to create biologically active substrates that mimic these matrices and target cell behaviour for a desired tissue engineering application. Indeed, the ability to tune their mechanical, structural, and biochemical properties provides a framework to recapitulate native tissues. This review explores how hydrogels have been engineered to harness the chondrogenic response of stem cells for the repair of damaged cartilage tissue. The signalling processes involved in hydrogel-driven chondrogenesis are also discussed, identifying critical pathways that should be taken into account during hydrogel design.
| Item Type: | Articles |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cantini, Dr Marco and Luo, Mr Jiajun and Walker, Dr Matthew and Pringle, Eonan |
| Authors: | Walker, M., Luo, J., Pringle, E. W., and Cantini, M. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Materials Science and Engineering C: Materials for Biological Applications |
| Publisher: | Elsevier |
| ISSN: | 0928-4931 |
| ISSN (Online): | 1873-0191 |
| Published Online: | 29 December 2020 |
| Copyright Holders: | Copyright © 2020 Elsevier B.V. |
| First Published: | First published in Materials Science and Engineering C: Materials for Biological Applications 121: 111822 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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Funder and Project Information
Funder and Project Information
Funder and Project Information
Project Code
Award No
Project Name
Principal Investigator
Funder's Name
Funder Ref
Lead Dept
Engineered microenvironments to harvest stem cell response to viscosity for cartilage repair
Marco Cantini
Medical Research Council (MRC)
MR/S005412/1
ENG - Biomedical Engineering
Deposit and Record Details
| ID Code: | 227229 |
| Depositing User: | Ms Jacqui Brannan |
| Datestamp: | 17 Dec 2020 14:11 |
| Last Modified: | 02 May 2025 07:27 |
| Date of acceptance: | 16 December 2020 |
| Date of first online publication: | 29 December 2020 |
| Date Deposited: | 17 December 2020 |
| Data Availability Statement: | No |
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