# ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells

**Source**: https://eprints.gla.ac.uk/227229/
**Parent**: https://eprints.gla.ac.uk/view/project_code/303613.html

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# ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells

[Walker, Matthew](https://eprints.gla.ac.uk/view/author/50025.html) [ORCID: https://orcid.org/0000-0001-5119-9118](https://orcid.org/0000-0001-5119-9118), [Luo, Jiajun](https://eprints.gla.ac.uk/view/author/55002.html), [Pringle, Eonan William](https://eprints.gla.ac.uk/view/author/60105.html) and [Cantini, Marco](https://eprints.gla.ac.uk/view/author/30437.html) [ORCID: https://orcid.org/0000-0003-0326-1508](https://orcid.org/0000-0003-0326-1508)
(2021)
ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells.
*[Materials Science and Engineering C: Materials for Biological Applications](https://eprints.gla.ac.uk/view/journal_volume/Materials_Science_and_Engineering_C=3A_Materials_for_Biological_Applications.html)*, 121,
111822.
(doi: [10.1016/j.msec.2020.111822](https://doi.org/10.1016/j.msec.2020.111822))
(PMID:[33579465](https://europepmc.org/abstract/MED/33579465))

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|  | [Text](https://eprints.gla.ac.uk/227229/2/227229.pdf)  227229.pdf - Accepted Version  Available under License [Creative Commons Attribution Non-commercial No Derivatives](http://creativecommons.org/licenses/by-nc-nd/4.0/).  2MB |

## Abstract

The extracellular matrix is a highly complex microenvironment, whose various components converge to regulate cell fate. Hydrogels, as water-swollen polymer networks composed by synthetic or natural materials, are ideal candidates to create biologically active substrates that mimic these matrices and target cell behaviour for a desired tissue engineering application. Indeed, the ability to tune their mechanical, structural, and biochemical properties provides a framework to recapitulate native tissues. This review explores how hydrogels have been engineered to harness the chondrogenic response of stem cells for the repair of damaged cartilage tissue. The signalling processes involved in hydrogel-driven chondrogenesis are also discussed, identifying critical pathways that should be taken into account during hydrogel design.

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| Item Type: | Articles |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | [Cantini, Dr Marco](https://eprints.gla.ac.uk/view/author/30437.html) and [Luo, Mr Jiajun](https://eprints.gla.ac.uk/view/author/55002.html) and [Walker, Dr Matthew](https://eprints.gla.ac.uk/view/author/50025.html) and [Pringle, Eonan](https://eprints.gla.ac.uk/view/author/60105.html) |
| Authors: | [Walker, M.](https://eprints.gla.ac.uk/view/author/50025.html), [Luo, J.](https://eprints.gla.ac.uk/view/author/55002.html), [Pringle, E. W.](https://eprints.gla.ac.uk/view/author/60105.html), and [Cantini, M.](https://eprints.gla.ac.uk/view/author/30437.html) |
| College/School: | [College of Science and Engineering](https://eprints.gla.ac.uk/view/divisions/30000000/) > [School of Engineering](https://eprints.gla.ac.uk/view/divisions/30300000/) > [Biomedical Engineering](https://eprints.gla.ac.uk/view/divisions/30303000/) |
| Journal Name: | [Materials Science and Engineering C: Materials for Biological Applications](https://eprints.gla.ac.uk/view/journal_volume/Materials_Science_and_Engineering_C=3A_Materials_for_Biological_Applications.html) |
| Publisher: | Elsevier |
| ISSN: | 0928-4931 |
| ISSN (Online): | 1873-0191 |
| Published Online: | 29 December 2020 |
| Copyright Holders: | Copyright © 2020 Elsevier B.V. |
| First Published: | First published in Materials Science and Engineering C: Materials for Biological Applications 121: 111822 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |

University Staff: [Request a correction](https://eprints.gla.ac.uk/cgi/request_correction?eprintid=227229) | Enlighten Editors: [Update this record](https://eprints.gla.ac.uk/cgi/users/home?screen=EPrint::View&eprintid=227229)

Funder and Project Information

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Project Code

Award No

Project Name

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Funder's Name

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Lead Dept

[303613](https://eprints.gla.ac.uk/view/project_code/303613.html)

Engineered microenvironments to harvest stem cell response to viscosity for cartilage repair

Marco Cantini

[Medical Research Council (MRC)](https://eprints.gla.ac.uk/view/funder/Medical_Research_Council_=28MRC=29.html)

MR/S005412/1

ENG - Biomedical Engineering

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| ID Code: | 227229 |
| Depositing User: | [Ms Jacqui Brannan](https://eprints.gla.ac.uk/profile/6299) |
| Datestamp: | 17 Dec 2020 14:11 |
| Last Modified: | 02 May 2025 07:27 |
| Date of acceptance: | 16 December 2020 |
| Date of first online publication: | 29 December 2020 |
| Date Deposited: | 17 December 2020 |
| Data Availability Statement: | No |

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