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Brown University
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Brown University

Source: https://bulletin.brown.edu/the-college/concentrations/bchm/ Parent: https://bulletin.brown.edu/azindex/

How does life work at the molecular level? This question is at the core of the concentration program Biochemistry and Molecular Biology. In earlier years of this discipline, the focus was on structure and function of proteins, nucleic acids, lipids, carbohydrates and small molecules such as vitamins. Today the logical approach and tools of biochemical science are being expanded to new areas in neuroscience, developmental biology, immunology, pharmacology and synthetic biology (the design of analogs of biological systems). Training in biochemistry begins with a foundation in mathematics, physics, chemistry and biology. Some courses offered in other departments, including engineering, geology and computer science, are also useful. A key component of this program is the year of hands-on research carried out in collaboration with a faculty member here at Brown. Faculty sponsors are drawn from both the Chemistry Department and the Division of Biology and Medicine, and include basic science and clinical faculty.

Standard program for the Sc.B. degree

Students must take twenty courses in biology, chemistry, mathematics, and physics, including the following core requirements, some of these may be fulfilled with AP credits.

Three courses in mathematics including two courses in MATH 0090/0100 or MATH 0170/0180 with a third class in statistics, math, or computer science 1 3
Options for statistics courses include: 1
APMA 0650 Introduction to Probability and Statistics
APMA 1650 Introduction to Probability and Statistics with Calculus
APMA 1655 Introduction to Probability and Statistics with Theory 3
BIOL 0495 Statistical Analysis of Biological Data
CPSY 0900 Statistical Methods
PHP 1501 Essentials of Data Analysis
PHP 1510 Principles of Biostatistics and Data Analysis
Two courses in physics, typically: 1 2
PHYS 0030 Basic Physics A
or PHYS 0050 Foundations of Mechanics
or ENGN 0040 Engineering Statics and Dynamics
PHYS 0040 Basic Physics B
or PHYS 0060 Foundations of Electromagnetism and Modern Physics
Three courses in physical and organic chemistry: 3
CHEM 0330 Equilibrium, Rate, and Structure
CHEM 0350 Organic Chemistry I
CHEM 0360 Organic Chemistry II
One course in biophysical chemistry: 1
CHEM 0400 Biophysical and Bioinorganic Chemistry
Four courses in biochemistry: 4
BIOL 0280 Biochemistry
BIOL 0285 Inquiry in Biochemistry: From Gene to Protein Function
Plus two of three upper level biochemistry courses:
BIOL 1270 Advanced Biochemistry
or CHEM 1230 Chemical Biology
or CHEM 1240 Biochemistry
The two semester research requirement may be satisfied by any two of the following. Students should discuss alternative arrangements or special situations directly with their concentration advisor to obtain prior approval. 2
Students should aim to complete this requirement in their junior year at the latest to maximize their ability to find a lab able to host them. Finding a lab involves reaching out to professors directly to inquire about research possibilities in their lab prior to receiving an override code for registration for BIOL1950/1960 or Chem 0980/0980S/0981.
BIOL 1950 Directed Research/Independent Study
BIOL 1960 Directed Research/Independent Study
CHEM 0980 Undergraduate Research
CHEM 0980S Undergraduate Research - Writing Designated and Mandatory S/NC
CHEM 0981 Undergraduate Research - Writing Designated
A summer research experience with faculty in Biology or Chemistry at Brown equivalent or greater in scope and scale to work the student would pursue in a Biology or Chemistry independent study course to satisfy one semester of the research requirement.
Suggested Elective Courses:
Students are required to take five courses from the chart below or, with approval from a concentration advisor, from any science or mathematics course relevant to biochemistry, cell and molecular biology. 5
Applied Mathematics Electives:
APMA 0330 Methods of Applied Mathematics I
APMA 0410 Mathematical Methods in the Brain Sciences
APMA 0650 Introduction to Probability and Statistics
Biology Electives:
BIOL 0030 Principles of Nutrition
BIOL 0150D Techniques in Regenerative Medicine: Cells, Scaffolds and Staining
BIOL 0170 Biotechnology in Medicine
BIOL 0190R Phage Hunters
BIOL 0200 The Foundation of Living Systems
BIOL 0380 The Ecology and Evolution of Infectious Disease
BIOL 0415 Microbes in the Environment
BIOL 0440 Inquiry in Plant Biology: Analysis of Plant Growth, Reproduction and Adaptive Responses
BIOL 0470 Genetics
BIOL 0500 Cell and Molecular Biology
BIOL 0510 Introductory Microbiology
BIOL 0530 Principles of Immunology
BIOL 0800 Principles of Physiology
BIOL 1050 Biology of the Eukaryotic Cell
BIOL 1090 Polymer Science for Biomaterials
BIOL 1100 Cell Physiology and Biophysics
BIOL 1110 Topics in Signal Transduction
BIOL 1120 Biomaterials
BIOL 1150 Stem Cell Engineering
BIOL 1200 Protein Biophysics and Structure
BIOL 1210 Synthetic Biological Systems
BIOL 1222A Current Topics in Functional Genomics
BIOL 1260 Physiological Pharmacology
BIOL 1290 Cancer Biology
BIOL 1300 Biomolecular Interactions: Health, Disease and Drug Design
BIOL 1310 Developmental Biology
BIOL 1330 Biology of Reproduction
BIOL 1520 Innate Immunity
BIOL 1540 Molecular Genetics
BIOL 1560 Virology
BIOL 1600 Development of Vaccines to Infectious Diseases
BIOL 2110 Drug and Gene Delivery
BIOL 2350 The Biology of Aging
Chemistry Electives:
CHEM 0500 Inorganic Chemistry
CHEM 1140 Physical Chemistry: Quantum Chemistry
CHEM 1150 Physical Chemistry: Thermodynamics and Statistical Mechanics
CHEM 1220 Computational Tools in Biochemistry and Chemical Biology
CHEM 1230 Chemical Biology
CHEM 1240 Biochemistry
CHEM 1450 Advanced Organic Chemistry
CHEM 1560H Chemical Glycobiology
CHEM 1560N Organometallic Chemistry
CHEM 2410 Organic Mechanisms
CHEM 2420 Organic Reactions
Computer Science Electives:
CSCI 0080 A First Byte of Computer Science
CSCI 0111 Computing Foundations: Data
CSCI 0150 Introduction to Object-Oriented Programming and Computer Science
CSCI 0160 Introduction to Algorithms and Data Structures
CSCI 0170 Computer Science: An Integrated Introduction
CSCI 0180 Computer Science: An Integrated Introduction
CSCI 0190 Accelerated Introduction to Computer Science
CSCI 1810 Computational Molecular Biology
Engineering Electives:
ENGN 0410 Materials Science
Neuroscience Electives: 2
NEUR 0010 The Brain: An Introduction to Neuroscience
NEUR 1020 Principles of Neurobiology
NEUR 1030 Neural Systems
NEUR 1040 Introduction to Neurogenetics
NEUR 1670 Neuropharmacology and Synaptic Transmission
NEUR 1740 The Diseased Brain: Mechanisms of Neurological and Psychiatric Disorders
Physics Electives:
PHYS 0160 Introduction to Relativity, Waves and Quantum Physics
Public Health Electives:
PHP 1501 Essentials of Data Analysis
Total Credits 20

1 : Note that the mathematics and physics requirements may be satisfied by Advanced Placement credit.

2 : or any NEUR course in Cell, Genetics, Molecular Biology, or Development.

3 : Students may opt to enroll in APMA 1655 for more in depth coverage of APMA 1650.

Honors Requirements for Biochemistry

All ScB Biochemistry concentrators are candidates for Honors; no separate application is necessary.

The requirements for Honors in Biochemistry are:

* Students must have a majority of either As or S with distinction grades in concentration courses.

* Two semesters of Independent Study (CHEM 0980, CHEM 0980S, CHEM 0981,  BIOL 1950, or BIOL 1960). Guidelines and requirements associated with Independent Study are in the Undergraduate Concentration Handbook which can be found at the department website.

* A Thesis in a form approved by the research advisor, and recommended by the research advisor.  Additional information about thesis guidelines will be provided by the Concentration Advisor in the first half of the fall semester.

* An oral presentation of the thesis in a fifteen-minute senior talk followed by a five-minute question and answer period.